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Heat Shock Gene Expression as a Marker of Ischemic and Other Types of Injury

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Book cover Cerebral Ischemia and Basic Mechanisms

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Abstract

While searching for markers of physiologically activated cells we discovered that the c-fos protooncogene could be induced by certain physiological stimuli including cortical stimulation, seizures, and osmotic stimulation [28]. It has since been shown that a variety of protooncogenes can be induced by physiological stimuli as well as by ischemia and axotomy [14, 15, 22]. We also found (concurrently with Dr. T. Nowak, Jr.) that though physiological stimuli would not induce the heat shock genes, a variety of injuries did induce these genes in brain. The following discussion will briefly summarize the biology of the heat shock gene response, the history of previous studies of heat shock protein expression in brain, and our work on the effect of seizures and ischemia on the induction of the hsp70 gene in specific cell types and the relevance of these observations to understanding the pathogenesis of ischemic brain injury.

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Author information

Authors and Affiliations

  1. Department of Neurology (V127), Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA, 94121, USA

    F. R. Sharp, J. Koistinaho & S. M. Sagar

  2. Department of Neurology, University of California at San Francisco, San Francisco, CA, 94143, USA

    F. R. Sharp, J. Koistinaho & S. M. Sagar

  3. Department of Neurosurgery, University of California at San Francisco, San Francisco, CA, 94143, USA

    H. Kinouchi & P. H. Chan

Authors
  1. F. R. Sharp
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  2. H. Kinouchi
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  3. J. Koistinaho
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  4. P. H. Chan
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  5. S. M. Sagar
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Straße 25, 53127, Bonn, Germany

    Alexander Hartmann

  2. Department of Neurology, Texas Medical Center, The University of Texas, 6431 Fannin, Suite 7.004 MSB, 77030, Houston, TX, USA

    Frank Yatsu

  3. Institut für Physiologie, Universität Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany

    Wolfgang Kuschinsky

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© 1994 Springer-Verlag Berlin Heidelberg

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Sharp, F.R., Kinouchi, H., Koistinaho, J., Chan, P.H., Sagar, S.M. (1994). Heat Shock Gene Expression as a Marker of Ischemic and Other Types of Injury. In: Hartmann, A., Yatsu, F., Kuschinsky, W. (eds) Cerebral Ischemia and Basic Mechanisms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78151-3_30

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  • DOI: https://doi.org/10.1007/978-3-642-78151-3_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78153-7

  • Online ISBN: 978-3-642-78151-3

  • eBook Packages: Springer Book Archive

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