Unsettled Role of Glutamate/Glutamate Receptors in Ischemic Excitotoxic Neuronal Damage

  • A. Sugimoto
  • A. Takeda
  • H. Onodera
  • S. Nakanishi
  • K. Kogure
Conference paper

Abstract

It has been a widely accepted hypothesis that the vulnerability of the brain cells to brief periods of ischemia is caused by the excitotoxicity of glutamate. As a matter of fact, almost all of these ischemia-susceptive neurons are densely innervated by glutamate fibers. In the case of pyramidal cells in the hippocampal CA1 sector, the glutamate fibers innervate the dendritic and the somal cell layers through multisynaptic, feed-foreward networks from the ipsilateral and the contralateral entorhinal cortex.

Keywords

Ischemia NMDA Kato Anisomycin 

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References

  1. Kato H, Liu Y, Araki T and Kogure K (1991) Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects. Brain Res 553: 238–242PubMedCrossRefGoogle Scholar
  2. Onodera H, Sato G and Kogure K (1986) Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells. Neurosci Lett 68: 169–174PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Sugimoto
    • 1
  • A. Takeda
    • 1
  • H. Onodera
    • 1
  • S. Nakanishi
    • 1
  • K. Kogure
    • 1
  1. 1.Institute of Brain DiseasesTohoku UniversitySendaiJapan

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