Unsettled Role of Glutamate/Glutamate Receptors in Ischemic Excitotoxic Neuronal Damage
It has been a widely accepted hypothesis that the vulnerability of the brain cells to brief periods of ischemia is caused by the excitotoxicity of glutamate. As a matter of fact, almost all of these ischemia-susceptive neurons are densely innervated by glutamate fibers. In the case of pyramidal cells in the hippocampal CA1 sector, the glutamate fibers innervate the dendritic and the somal cell layers through multisynaptic, feed-foreward networks from the ipsilateral and the contralateral entorhinal cortex.
KeywordsIschemia NMDA Kato Anisomycin
Unable to display preview. Download preview PDF.