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What Are We Learning from Clinical Trials in Acute Cerebral Ischemia?

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Book cover Cerebral Ischemia and Basic Mechanisms

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Abstract

At the beginning of the 1990s we can make a long list of studies on various pharmacological tools and approaches to the treatment of acute cerebral ischemia, such as osmotics, steroids, vasodilators, hemodilution, which have all systematically failed. We would rather not elaborate that discouraging list but think about how to make use of these negative experiences as examples of methodological errors which should not be repeated. Thus, studies with a poor diagnostic characterization of patients due to the lack of a computed tomography (CT) scan and trials carried out using insufficient sample sizes should never be performed.

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Author information

Authors and Affiliations

  1. Department of Neurological Sciences, University of Rome, La Sapienza, Viale dell’ Universita 30, 00174, Rome, Italy

    C. Fieschi, M. Frontoni, M. Fiorelli, M. L. Sacchetti, D. Toni, C. Argentino & M. C. Gori

Authors
  1. C. Fieschi
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  2. M. Frontoni
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  3. M. Fiorelli
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  4. M. L. Sacchetti
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  5. D. Toni
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  6. C. Argentino
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  7. M. C. Gori
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Straße 25, 53127, Bonn, Germany

    Alexander Hartmann

  2. Department of Neurology, Texas Medical Center, The University of Texas, 6431 Fannin, Suite 7.004 MSB, 77030, Houston, TX, USA

    Frank Yatsu

  3. Institut für Physiologie, Universität Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany

    Wolfgang Kuschinsky

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© 1994 Springer-Verlag Berlin Heidelberg

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Fieschi, C. et al. (1994). What Are We Learning from Clinical Trials in Acute Cerebral Ischemia?. In: Hartmann, A., Yatsu, F., Kuschinsky, W. (eds) Cerebral Ischemia and Basic Mechanisms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78151-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-78151-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78153-7

  • Online ISBN: 978-3-642-78151-3

  • eBook Packages: Springer Book Archive

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