Impact of Endothelial Cell-Seeding with Omentally Derived Microvascular Cells on the Long-Term Patency and Neointimal Hyperplasia in Small-Diameter Dacron Grafts
Although it has been shown that endothelial cell-seeding may reduce anastomotic intimal hyperplasia in animals with good early and midterm results , no long-term data are available. Anastomotic hyperplasia is characteristic of the normal healing process, but its precise control and the influence of complete endothelialization of a seeded prosthetic graft have still not been completely understood . Microvascular cells derived from omental tissue allow immediate high-density seeding; however, the isolates contain not only endothelial cells, but also a variety of other cell types . Despite approximately 95% endothelialization at 4 weeks, an inner capsule continues to accumulate beneath the endothelial monolayer , remaining a potential hazard for late occlusion during the long-term period .
Autotransplantation von mikrovaskulären Endothelzellen des Omentums mit kleinlumigen Dacronprothesen: Langzeitdurchgängigkeit und Neointimabildung
Unable to display preview. Download preview PDF.
- 1.Graham LM, Vincent CK, Brothers TE, Harrell KA, Darvishian D, Seil R, Burkel WE, Stanley JC (1988) Efficacy of antiplatelet agents in promoting patency and reducing anastomotic hyperplasia of endothelial cell seeded and unseeded ePTFE grafts. Surg Forum 39: 348–350Google Scholar
- 3.Sterpetti AV, Hunter WJ, Schultz RD, Sugimoto JT, Blair EA, Hacker K, Chasan P, Valentine J (1988) Seeding with endothelial cells derived from the miqrovessels of the Omentum and from the jugular vein: a comparative study. J Vase Surg 7: 677–684Google Scholar
- 7.Graham LM, Brothers TE, Vincent CK, Burkel WE, Stanley JC (1991) The role of an endothelial cell lining in limiting distal anastomotic intimal hyperplasia of 4-mm-I.D. Dacron grafts in a canine model. J Biomed Mat Res 25: 525–533Google Scholar
- 8.Bush HL, Jakubowski JA, Sentissi JM, Curl GR, Hayes JA, Deykin D (1987) Neointimal hyperplasia occurring after carotid endarterectomy in a canine model: effect of endothelial cell seeding vs. perioperative aspirin. J Vas Surg 5: 118–125Google Scholar