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Clinical and Immunological Approach to the Diagnosis of Immunodeficiencies

  • H. H. Peter
  • M. Armbruster
  • E. Baumert
  • H. P. Buscher
  • R. Dräger
  • E. W. Herbst
  • A. Jahreis
  • A. Kliche
  • J. A. Rump
  • P. Vaith
  • G. Wolff-Vorbeck
  • M. Schlesier
Conference paper

Abstract

The rational diagnosis of immunodeficiencies is increasingly gaining importance in clinical practice. The availibility of highly complex and expensive immunologic and molecular methods to identify subtle defects in the immune apparatus often contrasts with the limited immunological knowledge of the physicians in charge of immunocompromised patients. In this situation a practical guide for the diagnosis of immunodeficiencies may be helpful. Any evaluation should start with simple, informative, and inexpensive measures before proceeding to more complex, specialized, and expensive diagnostic procedures. Prime emphasis is placed on defects of the specific immune system, which account for 80%–90% of clinically relevant immunodeficiencies. The ultimate aim of each immunodiagnostic measure is the establishment of a validated diagnosis, the identification of etiological factors, and the proposal of a causal therapy.

Keywords

Common Variable Immunodeficiency Primary Immunodeficiency Disease CVID Patient Natural Killer Cell Function Pokeweed Mitogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H. H. Peter
  • M. Armbruster
  • E. Baumert
  • H. P. Buscher
  • R. Dräger
  • E. W. Herbst
  • A. Jahreis
  • A. Kliche
  • J. A. Rump
  • P. Vaith
  • G. Wolff-Vorbeck
  • M. Schlesier

There are no affiliations available

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