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Von Willebrand Factor as a Target for Antithrombotic Intervention

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Thrombolytic Therapy in Acute Ischemic Stroke II

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Abstract

The adhesive protein von Willebrand factor (vWF) is essential for the formation of platelet thrombi under flow conditions characterized by high shear stress. Two distinct platelet receptors, the glycoprotein (GP) complexes Ib-IX-V and Ilb-IIIa, are required for these interactions. Interaction with GP Ib-IX-V results in platelet activation, a necessary step for binding to GP Ilb-IIIa and stable aggregation. Inhibition of von Willebrand factor binding to GP Ib can be achieved with small recombinant fragments containing the specific functional domain of the von Willebrand factor molecule that interacts with this platelet receptor. Such fragments may provide a new selective approach to antithrombotic therapy.

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Authors and Affiliations

  1. Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Thrombosis and Hemostasis, Department of Molecular and Experimental Medicine and Committee on Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA

    Z. M. Ruggeri

Authors
  1. Z. M. Ruggeri
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Editors and Affiliations

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Gregory J. del Zoppo M.D.

  2. Neurology Service, Hyogo Brain and Heart Center at Himeji, 520 Saisho-ko, Himeji, 670, Japan

    Etsuro Mori M.D.

  3. Neurologische Klinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg 1, Germany

    Werner Hacke

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© 1993 Springer-Verlag Berlin Heidelberg

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Ruggeri, Z.M. (1993). Von Willebrand Factor as a Target for Antithrombotic Intervention. In: del Zoppo, G.J., Mori, E., Hacke, W. (eds) Thrombolytic Therapy in Acute Ischemic Stroke II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78061-5_36

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  • DOI: https://doi.org/10.1007/978-3-642-78061-5_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56442-3

  • Online ISBN: 978-3-642-78061-5

  • eBook Packages: Springer Book Archive

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