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Anti-PMN Leukocyte Strategies and Their Application to Focal Cerebral Ischemia

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Book cover Thrombolytic Therapy in Acute Ischemic Stroke II

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Abstract

In capillaries, the physical properties of individual cells contribute significantly to the rheology of blood and to organ perfusion. In this summary we consider the biophysical properties of circulating cells that determine their motion in the microcirculation and its disturbance in ischemia. The focus is on polymorphonuclear (PMN) leukocytes, their deformability, adhesive properties and cytotoxicity. The intravascular pool of PMN leukocytes will be considered and the mechanism of the non-reflow phenomena in the cerebral microcirculation.

Supported in part by a grant from NS26945 (GJdZ) of the National Institutes of Health. This is publication number 7427-MEM from The Scripps Research Institute, La Jolla, CA, USA.

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Author information

Authors and Affiliations

  1. Institute for Biomedical Engineering, University of California, San Diego, CA, USA

    G. W. Schmid-Schönbein

  2. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA

    G. J. del Zoppo

Authors
  1. G. W. Schmid-Schönbein
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  2. G. J. del Zoppo
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Editor information

Editors and Affiliations

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Gregory J. del Zoppo M.D.

  2. Neurology Service, Hyogo Brain and Heart Center at Himeji, 520 Saisho-ko, Himeji, 670, Japan

    Etsuro Mori M.D.

  3. Neurologische Klinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 400, W-6900, Heidelberg 1, Germany

    Werner Hacke

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© 1993 Springer-Verlag Berlin Heidelberg

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Schmid-Schönbein, G.W., del Zoppo, G.J. (1993). Anti-PMN Leukocyte Strategies and Their Application to Focal Cerebral Ischemia. In: del Zoppo, G.J., Mori, E., Hacke, W. (eds) Thrombolytic Therapy in Acute Ischemic Stroke II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78061-5_35

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  • DOI: https://doi.org/10.1007/978-3-642-78061-5_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56442-3

  • Online ISBN: 978-3-642-78061-5

  • eBook Packages: Springer Book Archive

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