Ovarian Carcinoma: Tumor- and Molecular Biology

  • B. Kacinski
Part of the AGO Arbeitsgemeinschaft für Gynäkologische Onkologie book series (AGO)


During the normal monthly ovulatory cycle, ovarian surface epithelium undergoes a set of changes including destruction, proliferation, and regeneration which is regulated by many (peptide and steroid) hormones and their receptors. The corresponding genes transduce receptor/ligand signals to alter DNA synthesis and gene expression. Point mutation, rearrangement, or deletions of chromosomal DNA sequences which alter the function and/or expression of these genes might sufficiently perturb normal ovarian epithelial cell proliferation and differentiation to produce benign, borderline, and invasively-ma- lignant neoplasms from normal surface epithelium.


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© Springer-Verlag Berlin Heidelberg 1993

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  • B. Kacinski

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