The Effect of Immunological Blockade of Reissner’s Fiber Formation on the Circulation of Cerebrospinal Fluid Along the Central Canal of the Rat Spinal Cord

  • P. Fernández-Llebrez
  • M. Cifuentes
  • J. M. Grondona
  • J. Pérez
  • E. M. Rodríguez


Although the subcommissural organ—Reissner’s fiber (SCO—RF) complex was first described almost a century ago, the function of this conspicuous glandular structure of the brain remains enigmatic. Several functional hypotheses have been proposed based on indirect evidence. Briefly, the SCO—RF has been suspected to be involved in: (1) osmoregulation (Palkovits et al. 1965; Leatherland and Dodd 1968), (2) detoxification of the cerebrospinal fluid (CSF) (Olsson 1958; Hess and Sterba 1973; Diederen et al. 1983), (3) mechanoreception (Kolmer 1921), and (4) morphogenesis of the vertebral column and the spinal cord (Hauser 1969; Rühle 1971). However, none of these hypotheses has been properly substantiated.


Spinal Cord Ependymal Cell Spinal Segment Central Canal Subcommissural Organ 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. Fernández-Llebrez
  • M. Cifuentes
  • J. M. Grondona
  • J. Pérez
  • E. M. Rodríguez

There are no affiliations available

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