The Subcommissural Organ: Immunohistochemistry and Potential Relations to Salt/Water Balance
The subcommissural organ (SCO) seems to be an “orphan” among the circumventricular organs (CVO). It attracts relatively little research activity and there is no clear-cut indication of what normal physiological function(s) it contributes to the day-to-day life of an animal. By contrast, other CVOs with more clearly defined roles attract considerable research effort. For example, the area postrema and the nearby nucleus tractus solitarius are well known for their involvement in cardiovascular reflex mechanisms (Miselis et al. 1987). Similarly, there is considerable information, including anatomical connectivity, about the subfornical organ and its linkage to water ingestion and vasopressin secretion (Lind 1987).
KeywordsTyrosine Hydroxylase Intracranial Hypertension Choroid Plexus Circumventricular Organ Congenital Hydrocephalus
Unable to display preview. Download preview PDF.
- Dundore RL (1985) Studies on the subcommissural organ area in the rat: the effects of aldosterone infused into the central nervous system, Ph D Thesis, Pennsylvania State University, HersheyGoogle Scholar
- Green JP (1989) Histamine and serotonin. In: Siegel G, Agranoff B, Albers RW, Molinoff P (eds) Basic neurochemistry, 4th edn. Raven, New York, p 253Google Scholar
- Lind RW (1987) The subfornical organ: neural connections. In: Gross PM (ed) Circum ventricular organs and body fluids, vol I. CRC Press, New York, p 27Google Scholar
- Miselis RR, Shapiro RE, Hyde TM (1987) The area postrema. In: Gross PM (ed) Circumventricular organs and body fluids, vol II. CRC Press, New York, pp 185–207Google Scholar
- Morrow BA, Starcevic VP, Keil LC, Severs WB (1990) Intracranial hypertension after cerebro ventricular infusions in conscious rats. Am J Physiol 258: R1170-R-1176Google Scholar
- Palkovits M ( 1987 Summary of structural and functional aspects of the circumventricular organs. In: Gross PM (ed) Circumventricular organs and body fluids, vol II. CRC Press, New York, pp 209–218Google Scholar
- Rodríguez S, Rodríguez EM, Jara P, Peruzzo B, Oksche A (1990) Single injection into the cerebrospinal fluid of antibodies against the secretory material of the subcommissural organ reversibly blocks formation of Reissner’s fiber: immunocytochemical investigations in the rat. Exp Brain Res 81: 113–124PubMedCrossRefGoogle Scholar
- Sallamon M, Buda C, Janin M, Jouvet M (1984) Effects of lesion of subcommissural organ on sleep in the cat. Neurosci Lett 49: 12–126Google Scholar
- Severs WB, Dundore RL, Balaban CD (1987) The subcommissural organ and Reissner’s fiber: Physiological regulation. In: Gross PM (ed) Circumventricular organs and body fluids, vol II. CRC Press, New York, pp 43–58Google Scholar