The Subcommissural Organ: Immunohistochemistry and Potential Relations to Salt/Water Balance

  • W. B. Severs
  • C. D. Balaban
  • B. A. Morrow
  • C. L. Snyder
  • L. C. Keil


The subcommissural organ (SCO) seems to be an “orphan” among the circumventricular organs (CVO). It attracts relatively little research activity and there is no clear-cut indication of what normal physiological function(s) it contributes to the day-to-day life of an animal. By contrast, other CVOs with more clearly defined roles attract considerable research effort. For example, the area postrema and the nearby nucleus tractus solitarius are well known for their involvement in cardiovascular reflex mechanisms (Miselis et al. 1987). Similarly, there is considerable information, including anatomical connectivity, about the subfornical organ and its linkage to water ingestion and vasopressin secretion (Lind 1987).


Tyrosine Hydroxylase Intracranial Hypertension Choroid Plexus Circumventricular Organ Congenital Hydrocephalus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Balaban CD, Billingsley ML, Kincaid RL (1989) Evidence for trans-synaptic regulation of calmodulin-dependent cyclic nucleotide phosphodiesterase in cerebellar Purkinje cells. J Neurosci 9: 2374–2381PubMedGoogle Scholar
  2. Billingsley ML, Balaban CD, Berresheim U, Kuhn DM (1986) Comparative studies on the distribution of protein O-carboxymethyltransferase and tyrosine hydroxylase in rat brain by immunocytochemistry. Neurochem Int 8: 255–265PubMedCrossRefGoogle Scholar
  3. Bouchaud C, Bosler O (1986) The circumventricular organs of the mammalian brain with special reference to monoaminergic innervation. Int Rev Cytol 105: 283–327PubMedCrossRefGoogle Scholar
  4. Dundore RL (1985) Studies on the subcommissural organ area in the rat: the effects of aldosterone infused into the central nervous system, Ph D Thesis, Pennsylvania State University, HersheyGoogle Scholar
  5. Dundore RL, Wurpel JND, Balaban CD, Keil LC, Severs WB (1984) Central effects of aldosterone infused into the rat subcommissural organ region. Neurosci Res 1: 341–351PubMedCrossRefGoogle Scholar
  6. Dundore RL, Wurpel JND, Balaban CD, Harrison TS, Keil LC, Seaton JF, Severs WB (1987) Site-dependent central effects of aldosterone in rats. Brain Res 401: 122–131PubMedCrossRefGoogle Scholar
  7. Gilbert GJ, Armstrong EP (1966) The effect of epinephrine upon subcommissural organ secretion in the rat. Neurology 16: 236–241PubMedGoogle Scholar
  8. Green JP (1989) Histamine and serotonin. In: Siegel G, Agranoff B, Albers RW, Molinoff P (eds) Basic neurochemistry, 4th edn. Raven, New York, p 253Google Scholar
  9. Hook GR, Odeyale CO (1989) Confocal scanning fluorescence microscopy: a new method for phagocytosis research. J Leukocyte Biol 45: 277–282PubMedGoogle Scholar
  10. Irigoin C, Rodríguez EM, Heinrichs M, Frese K, Herzog S, Oksche A, Rott R (1990) Immunocytochemical study of the subcommissural organ of rats with induced postnatal hydrocephalus. Exp Brain Res 82: 384–392PubMedCrossRefGoogle Scholar
  11. Limonta P, Maggi I, Martini L, Piva F (1982) Role of the subcommissural organ in the control of gonadotrophin secretion in the female rat. J Endocrinol 95: 207–214PubMedCrossRefGoogle Scholar
  12. Lind RW (1987) The subfornical organ: neural connections. In: Gross PM (ed) Circum ventricular organs and body fluids, vol I. CRC Press, New York, p 27Google Scholar
  13. McLean IW, Nakane PK (1974) Periodate-lysine paraformaldehyde fixative: a new fixative for immunoelectron microscopy. J Histochem Cytochem 22: 1077–1083PubMedCrossRefGoogle Scholar
  14. Miselis RR, Shapiro RE, Hyde TM (1987) The area postrema. In: Gross PM (ed) Circumventricular organs and body fluids, vol II. CRC Press, New York, pp 185–207Google Scholar
  15. Morrow BA, Holt MR, Starcevic VP, Keil LC, Severs WB (1992) Mechanism of delayed intracranial hypertension after cerebroventricular infusions in conscious rats. Brain Res 570: 218–224PubMedCrossRefGoogle Scholar
  16. Morrow BA, Starcevic VP, Keil LC, Severs WB (1990) Intracranial hypertension after cerebro ventricular infusions in conscious rats. Am J Physiol 258: R1170-R-1176Google Scholar
  17. Palkovits M ( 1987 Summary of structural and functional aspects of the circumventricular organs. In: Gross PM (ed) Circumventricular organs and body fluids, vol II. CRC Press, New York, pp 209–218Google Scholar
  18. Rodríguez S, Rodríguez EM, Jara P, Peruzzo B, Oksche A (1990) Single injection into the cerebrospinal fluid of antibodies against the secretory material of the subcommissural organ reversibly blocks formation of Reissner’s fiber: immunocytochemical investigations in the rat. Exp Brain Res 81: 113–124PubMedCrossRefGoogle Scholar
  19. Sallamon M, Buda C, Janin M, Jouvet M (1984) Effects of lesion of subcommissural organ on sleep in the cat. Neurosci Lett 49: 12–126Google Scholar
  20. Severs WB, Dundore RL, Balaban CD (1987) The subcommissural organ and Reissner’s fiber: Physiological regulation. In: Gross PM (ed) Circumventricular organs and body fluids, vol II. CRC Press, New York, pp 43–58Google Scholar
  21. Sorensen PS (1986) Studies of vasopressin in the human cerebrospinal fluid. Acta Neurol Scand 74: 81–102PubMedCrossRefGoogle Scholar
  22. Stepien H, Stawawy A, Cieslak D, Brzezinski J, Pawlikowski M (1986) Increased CSF levels of somatostatin in patients with brain tumors and intracranial hypertension. Horm Metab Res 18: 555–557PubMedCrossRefGoogle Scholar
  23. Takeuchi YK, Takeuchi IK (1990) Critical period for induction of congenital hydrocephalus and dysplasia of subcommissural organ by prenatal X-irradiation in fats. Experientia 46: 446–449PubMedCrossRefGoogle Scholar
  24. Takeuchi IK, Kimura R, Matsuda M, Shoji R (1987) Absence of subcommissural organ in the cerebral aqueduct of congenital hydrocephalus spontaneously occurring in MT/HokIdr mice. Acta Neuropathol (Berl) 73: 320–322CrossRefGoogle Scholar
  25. Takeuchi IK, Kimura R, Shoji R (1988) Dysplasia of subcommissural organ in congenital hydrocephalus spontaneously occurring in CWS/Idr rats. Experientia 44: 338–340PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • W. B. Severs
  • C. D. Balaban
  • B. A. Morrow
  • C. L. Snyder
  • L. C. Keil

There are no affiliations available

Personalised recommendations