Impairment of the Serotoninergic Innervation of the Rat Subcommissural Organ After Early Postnatal X-Irradiation of the Brain Stem
The rat subcommissural organ (SCO) is remarkable for the glandular activity of its ependymocytes, which release their secretory products in the cerebrospinal fluid. Great attention has been paid to the nervous input to the SCO and marked species differences have been reported (see review by Bouchaud, this volume). In all mammals, in contrast to many other regions of the ventricular lining, the apical surface of the SCO is devoid of a supraependymal serotoninergic plexus; however, in the rat, the basal part of the organ is innervated by a dense plexus of fine serotoninergic fibers arising from different raphe nuclei (Léger et al. 1983). The serotoninergic fibers run between the SCO ependymocytes and their axonal varicosities form true synaptic contacts, mainly with the laterobasal portion of the ependymocytes (Bouchaud and Arluison 1977).
KeywordsEpendymal Cell Subcommissural Organ Axonal Varicosity Synaptic Differentiation Bioi Cell
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