Transformation in Catharanthus Species (Madagascar Periwinkle)

  • C. David
  • J. Tempé
Part of the Biotechnology in Agriculture and Forestry book series (AGRICULTURE, volume 22)


Secondary metabolite production by plant cell cultures has been the subject of many investigations. Indole alkaloids such as ajmalicine, an antihypertensive drug, or vinblastine and vincristin, two antitumor compounds produced by Catharanthus roseus, are very important in the pharmaceutical industry. Cell cultures from the same plant species have been propagated in several laboratories since they are expected to produce physiologically potent indole alkaloids (Carew 1975). Undifferentiated cell lines producing high yields of ajmalicine, or serpentine, that can be easily converted into ajmalicine by reduction, have been obtained by selection (Zenk et al. 1977).


Hairy Root Root Culture Hairy Root Culture Crown Gall Indole Alkaloid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • C. David
    • 1
  • J. Tempé
    • 1
    • 2
  1. 1.Institut des Sciences VégétalesCNRSGif sur YvetteFrance
  2. 2.Institut National Agronomique Paris GrignonParisFrance

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