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Physiology and Pharmacology of Bone pp 267–298Cite as

Mineralization

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 107))

Abstract

The critical role of cells in biologic mineralization is becoming more and more evident. The following observations point to cells as the most important controlling factor in the initiation and propagation of mineral: (1) During development, cell-derived inductive signals direct skeletal cells to enter pathways of differentiation characteristic of mineralizing tissues. (2) Skeletal cells secrete the extracellular matrix into which mineral is selectively deposited. (3) Differentiated skeletal cells generate matrix vesicles (MVs) which are slectively placed in the matrix to serve as initial sites for mineral deposition and to control the distribution of mineral. (4) Cells control the composition of the matrix, thereby promoting or inhibiting mineral deposition. (5) Cells control the ionic and chemical milieu in which mineralization occurs.

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Anderson, H.C., Morris, D.C. (1993). Mineralization. In: Physiology and Pharmacology of Bone. Handbook of Experimental Pharmacology, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77991-6_8

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