Bone Remodeling and Bone Structure

  • E. F. Eriksen
  • A. Vesterby
  • M. Kassem
  • F. Melsen
  • L. Mosekilde
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 107)

Abstract

Bone remodeling constitutes the lifelong renewal process of bone whereby the mechanical integrity of the skeleton is preserved. It implies the continuous removal of bone (bone resorption) followed by synthesis of new bone matrix and subsequent mineralization (bone formation). Moreover, bone remodeling is an integral part of the calcium homeostatic system together with the kidneys and the gut. The ever ongoing removal of old bone by osteoclastic resorption and subsequent coupled osteoblastic formation of new bone leads to liberation of calcium and matrix constituents to serum.

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References

  1. Aaron JE, Makins NB, Sagreiya K (1987) The microanatomy of trabecular bone loss in normal ageing men and women. Clin Orthop 215:260–271PubMedGoogle Scholar
  2. Adams P, Jowsey J (1967) Bone and mineral metabolism in hyperthyroidism: an experimental study. Endocrinology 81:735–740PubMedCrossRefGoogle Scholar
  3. Agerbæk MO, Eriksen EF, Kragstrup J, Mosekilde L, Meisen F (1991) Reconstruc- tion of the remodeling sequence in normal human cortical bone. Bone Miner 12:101–112PubMedCrossRefGoogle Scholar
  4. Aloia JF, Vaswani A, Meunier PJ, Edouard CM, Arlot ME, Yeh JK, Cohn SH (1987) Coherence treatment of postmenopausal osteoporosis with growth hormone and calcitonin. Calcif Tissue Int 40:253–259PubMedCrossRefGoogle Scholar
  5. Amstutz HC, Sissons HA (1969) The structure of vertebral spongiosa. J Bone Joint Surg [Br] 51:540–550Google Scholar
  6. Arlot M, Edouard C, Meunier PJ, Neer R, Reeve J (1984) Impaired osteoblast function in osteoporosis: comparison between calciu balance and dynamic histomorphometry. Br Med J 289:517–520CrossRefGoogle Scholar
  7. Arnold JS (1968) External and trabecular morphologic changes in lumbar vertebrae in aging. In: Whedon GD, Cameron JR (eds) Progress in methods of bone mineral measurements. US Department of Health, Education and Welfare, Bethesda, p 370Google Scholar
  8. Arnold JS (1980) Trabecular pattern and shapes in aging and osteoporosis. Metab Bone Dis Rel Res 2S: 297–308Google Scholar
  9. Arnold JS, Wei CT (1972) Quantitative morphology of vertebral trabecular bone. In: Stover BJ, Jee WSS (eds) Radiobiology of plutonium. JW, Salt Lake City, p 333Google Scholar
  10. Arnold JS, Bartley MH, Tont SA, Jenkins DP (1966) Skeletal changes in aging and disease. Clin Orthop 49:17–38PubMedGoogle Scholar
  11. Atkinson PJ (1967) Variation in trabecular structure of vertebrae with age. Calcif Tissue Res 1:24–32PubMedCrossRefGoogle Scholar
  12. Baddeley AJ, Gundersen HJG, Cruz Orive LM (1986) Estimation of surface area from vertical sections. J Microsc 142:259–276PubMedCrossRefGoogle Scholar
  13. Baron R, Vignery A, Lang R (1981a) Reversal phase and osteopenia: defective coupling between resorption and formation in the pathogenesis of osteoporosis. In DeLuca HF, Frost HM, Jee WSS, Johnston CC, Parfitt AM (eds) Osteoporosis, recent advances in pathogenesis and treatment. University Park Press, Baltimore, p 311Google Scholar
  14. Baron R, Vignery A, Tran Van P (1981b) The significance of lacunar erosion without osteoclasts. Studies in the reversal phase of the remodeling sequence. In: Jee WSS, Parfitt AM (eds) Bone histomorphometry, 3rd international workshop. Armour Montagu, Paris, p 35Google Scholar
  15. Bartley MH, Arnold JS, Haslam RK, Jee WSS (1966) The relationship of bone strength and bone quantity in health, disease, and aging. J Gerontol 21:517–521PubMedGoogle Scholar
  16. Beddoe AH, Darley PJ, Spiers FW (1976) Measurements of trabecular bone struc- ture in man. Phys Med Biol 21:589–607PubMedCrossRefGoogle Scholar
  17. Bell GH, Dunbar O, Beck JS (1967) Variations in strength of vertebrae with age and their relation to osteoporosis. Calcif Tissue Res 1:75–86PubMedCrossRefGoogle Scholar
  18. Bergot C, Laval–Jeantet AM, Preteux F, Meunier A (1988) Measurement of anistropic vertebral trabecular bone loss during aging by quantitative image analysis. Calcif Tissue Int 43:143–149PubMedCrossRefGoogle Scholar
  19. Birkenhaeger-Frenkel DH, Courpron P, Clermont E, Hupscher C, Coutinho MF, Meunier PJ (1986) Trabecular thickness, intertrabecular distance and age related bone loss. Bone 6:402CrossRefGoogle Scholar
  20. Birkenhager-Frenkel DH, Courpron P, Hupscher EA, Clermonts E, Coutinho MF, Schmitz PIM, Meunier PJ (1988) Age-related changes in cancellous bone struc- ture. A two-dimensional study in transiliac and iliac crest biopsy sites. Bone Miner 5:197–216Google Scholar
  21. Boyce RW, Eriksen EF, Franks AF, Jankowsky ML, Stokes CL (1989) Effects of intermittent hPTH (l–34) alone or in combination with oral l,25(OH)2D3 on trabecular bone: 3-D reconstruction of the remodeling site. J Bone Miner Res 4:S276Google Scholar
  22. Bressot C, Meunier PJ, Chapuy MC, Lejeune E, Edouard C, Darby AJ (1979) Histomorphometric profile, pathophysiology and reversibility of corticosteroid induced osteoporosis. Metab Bone Dis Rel Res 1:303–311CrossRefGoogle Scholar
  23. Bromley RG, Dockum NL, Arnold JS, Jee WSS (1966) Quantitative histological study of human lumbar vertebrae. J Gerontol 21:537–543PubMedGoogle Scholar
  24. Broulik P, Kragstrup J, Mosekilde L, Meisen F (1982) Osteon cross-sectional size in the iliac crest. Acta Path Microbiol Scand Sect A 90:339–344Google Scholar
  25. Charhon SA, Edouard CM, Arlot M, Meunier PJ (1982) Effects of parathyroid hormone on remodeling of iliac trabecular bone packets in patients with primary hyperparathyroidism. Clin Orthop 162:255–263PubMedGoogle Scholar
  26. Charles P, Poser JW, Mosekilde L, Jensen FT (1985) Estimation of bone turnover evaluated by 47calcium kinetics. Efficiency of serum bone gamma carboxyglutamic acid containing protein, serum alkaline phosphatase and urinary hydroxyproline excretion. J Clin Invest 76:2254–2258PubMedCrossRefGoogle Scholar
  27. Charles P, Eriksen EF, Mosekilde L, Meisen F, Jensen FT (1987) Bone turn- over evaluated by a combined calcium balance and 47calcium kinetic study and dynamic histomorphometry. Metabolism 36:1118–1124PubMedCrossRefGoogle Scholar
  28. Christiansen P, Steiniche T, Mosekilde Le, Hessov I, Meisen F (1990) Primary hyperparathyroidism: changes in trabecular bone remodeling following surgical treatment evaluated by histomorphometric methods. Bone 11:75–80PubMedCrossRefGoogle Scholar
  29. Compston JE, Mellish RWE, Garrahan NJ (1987) Age-related changes in iliac crest trabecular microanatomic bone structure in man. Bone 8:289–292PubMedCrossRefGoogle Scholar
  30. Compston JE, Mellish RW, Croucher P, Newcombe R, Garrahan NJ (1989) Structural mechanisms of trabecular bone loss in man. Bone Miner 6:339–350PubMedCrossRefGoogle Scholar
  31. Courpron P, Meunier P, Bressot C, Giroux JM (1977) Amount of bone in iliac crest biopsy. Significance of the trabecular bone volume. Its value in normal and in pathological conditions. In: Meunier PJ (ed) Bone histomorphometry, 2nd international workshop. Armour Montagu, Paris, p 39Google Scholar
  32. Courpron P, Lepine P, Arlot M, Lips R, Meunier PJ (1981) Mechanisms underlying the reduction with age of the mean wall thickness of the trabecular basic structural unit (BSU) in human iliac bone. In: Jee WSS, Parfitt AM (eds) Bone histomorphometry, 3rd international workshop. Armour Montagu, Paris, p 323Google Scholar
  33. Croucher PI, Mellish RWE, Vedi S, Garrahan NJ, Compston J (1989) The relation- ship between resorption depth and mean interstitial bone thickness: age related changes in man. Calcif Tissue Int 45:15–19PubMedCrossRefGoogle Scholar
  34. Delmas PD, Demiaux B, Arlot MA, Edouard C, Malaval L, Meunier PJ (1990) Relationship between bone histomorphometric parameters and biochemical markers of bone turnover. In: Takahashi HE (ed) Bone histomorphometry, Nishimura Niigata, Japan, Smith Gordon, London, p 488Google Scholar
  35. Dempster DW, Arlot MN, Meunier PJ (1983) Mean wall thickness and bone forma- tion periods of trabecular bone packets in corticosteroid induced osteoporosis. Calcif Tissue Int 35:410–415PubMedCrossRefGoogle Scholar
  36. Dempster DW, Shane E, Horbert W, Lindsay R (1986) A simple method for correlative light and scanning electron microscopy of human iliac crest bone biopsies: qualitative observations in normal and osteoporotic subjects. J Bone Miner Res 1:15–21PubMedCrossRefGoogle Scholar
  37. D’Souza DM, Ibbotson KJ, Twardzik DR et al. (1986) Transforming growth factor beta (TGF–beta) resorbs bone and is produced by osteoblast like cells. J Bone Miner Res 1:74Google Scholar
  38. Eriksen EF (1986) Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev 7:379–408PubMedCrossRefGoogle Scholar
  39. Eriksen EF (1992) Osteoporosis. Novo–Nordisk A/SGoogle Scholar
  40. Eriksen EF, Meisen F, Mosekilde L (1984a) Reconstruction of the resorptive site in iliac trabecular bone: a kinetic model for bone resorption in 20 normal individ- uals. Metab Bone Dis Rel Res 5:235–242CrossRefGoogle Scholar
  41. Eriksen EF, Gundersen HJG, Meisen F, Mosekilde L (1984b) Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing a kinetic model for matrix and mineral apposition. Metab Bone Dis Rel Res 5:243–252CrossRefGoogle Scholar
  42. Eriksen EF, Mosekilde L, Meisen F (1985a) Trabecular bone resorption depth decreases with age: differences between normal males and females. Bone 6: 141–146PubMedCrossRefGoogle Scholar
  43. Eriksen EF, Mosekilde L, Meisen F (1985b) Trabecular bone remodeling and bone balance in hyperthyroidism. Bone 6:421–428PubMedCrossRefGoogle Scholar
  44. Eriksen EF, Mosekilde L, Meisen F (1985c) Effect of sodium fluoride, calcium phosphate and vitamin D2 on trabecular bone balance and remodeling in osteoporosis. Bone 6:381–389PubMedCrossRefGoogle Scholar
  45. Eriksen EF, Mosekilde L, Meisen F (1985d) Kinetics of trabecular bone resorption and formation in hypothyroidism: evidence for a positive balance per remodeling cycle. Bone 7:101–108CrossRefGoogle Scholar
  46. Eriksen EF, Mosekilde L, Meisen F (1986) Trabecular bone remodeling and bone balance in primary hyperparathyroidism. Bone 7:213–221PubMedCrossRefGoogle Scholar
  47. Eriksen EF, Kumar EV, Riggs BL (1987) New developments in medicine, vol 2. Bender, New York, pp 11–23Google Scholar
  48. Eriksen EF, Steiniche T, Mosekilde L, Meisen F (1989) Histomorphometric analysis of bone in metabolic bone disease. Endocrinol Metab Clin North Am 18: 919–954PubMedGoogle Scholar
  49. Eriksen EF, Hodgson SF, Eastell R, Cedel SR, O’Fallon WM, Riggs BL (1990) Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantita- tive assessment of rates of formation, resorption and bone loss at tissue and cellular levels. J Bone Miner Res 5:311–319PubMedCrossRefGoogle Scholar
  50. Farley JR, Wergedal JE, Baylink DJ (1983) Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone forming cells. Science 222:330–332PubMedCrossRefGoogle Scholar
  51. Findling JW, Adams ND, Leman L (1982) Vitamin D metabolites and parathyroid hromone in Cushing’s syndrome: relationship to calcium and phosphorous metabolism. J Clin Endocrinol Metab 54:1034–1044CrossRefGoogle Scholar
  52. Frost HM (1964) Dynamics of bone remodeling. In: Frost HM (ed) Bone bio- dynamics. Little Brown, Boston, pp 315–333Google Scholar
  53. Frost HM (1969) Tetracycline based histological analysis of bone remodeling. Calcif Tissue Res 3:211–237PubMedCrossRefGoogle Scholar
  54. Frost HM (1979) Treatment of osteoporoses by manipulation of coherent cell populations. Clin Orthop 143:227–244PubMedGoogle Scholar
  55. Frost HM (1989) Some effects of basic multicellular unit-based remodelling on photon absorptiometry of trabecular bone. Bone Miner 7:47–65PubMedCrossRefGoogle Scholar
  56. Frost HM (1990) Structural adaptation to mechanical usage. Anat Rec 222:403–439CrossRefGoogle Scholar
  57. Frost HM, Villanueva AR (1962) Human osteoclastic activity: qualitative histological measurement. Henry Ford Hosp Med Bull 10:229–236PubMedGoogle Scholar
  58. Frost HM, Villanueva AR, Jaworski ZF, Meunier P, Schimizu AG (1969) Evalua- tion of cellular level Haversian bone resorption in human hyperparathyroid states. Henry Ford Hosp Med J 17:259–266PubMedGoogle Scholar
  59. Galante J, Rostoker W, Ray RD (1970) Physical properties of trabecular bone. Calcif Tissue Res 5:236–246PubMedCrossRefGoogle Scholar
  60. Garn SM, Rohmann CG, Wagner B, Ascoli W (1967) Continuing bone growth throughout life: a general phenomenon. J Phys Anthropol 26:313–318CrossRefGoogle Scholar
  61. Garrahan NJ, Mellish RWE, Compston JE (1985) A new method for the two- dimensional analysis of bone structure in human iliac crest biopsies. J Microsc 142:341–349CrossRefGoogle Scholar
  62. Garrahan NJ, Mellish RWE, Vedi S, Compston JE (1987) Measurement of mean trabecular plate thickness by a new computerized method. Bone 8:227–230PubMedCrossRefGoogle Scholar
  63. Garrahan NJ, Croucher PI, Compston J (1990) A computerized technique for the quantitative assessment of resorption cavities in trabecular bone. Bone 11: 241–245PubMedCrossRefGoogle Scholar
  64. Gundersen HJG, Jensen EB (1985) Stereological estimation of the volume-weighted mean volume of arbitrary particles observed on random sections. J Microsc 138:127–142PubMedCrossRefGoogle Scholar
  65. Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moeller A, Nielsen K, Nyengaard JR, Pakkenberg B, Soerensen FB, Vesterby A, West MJ (1988) The new stereologic tools: disector, fractionator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96:857–881PubMedCrossRefGoogle Scholar
  66. Halse J, Meisen F, Mosekilde L (1981) Iliac crest bone mass and remodelling in acromegaly. Acta Endocrinol (Copenh) 97:18–22Google Scholar
  67. Hattner R, Epker BN, Frost HM (1965) Kinetics of osteoclasts and their nuclei in evolving secondary haversian systems. J Anat 133:397–402Google Scholar
  68. Hodgson SF (1990) Corticosteroid induced osteoporosis. In: Tiegs RD (ed) Metabolic bone disease, part II. Endocrinology and metabolism clinics of North America. Saunders Philadelphia, p 95Google Scholar
  69. Hori M, Takahashi T, Konno J, Habs T (1985) A classification of in vivo bone labels after double labeling in canine bones. Bone 6:147–154PubMedCrossRefGoogle Scholar
  70. Jaworski ZFG (1971) Some morphologic and dynamic aspects of remodelling in endosteal–cortical and trabecular surfaces. In: Menczel J, Harell A (eds) Calcified tissue: structural, functional and metabolic aspects. Academic, New York, p 159Google Scholar
  71. Jaworski ZF, Lok E (1972) The rate of osteoclastic bone resorption in haversian remodeling sites of adult dogs rib. Calcif Tissue Res 10:103–108PubMedCrossRefGoogle Scholar
  72. Jerome CP (1989) Estimation of bone mineral density variation associated with changes in turnover rate. Calcif Tissue Int 44:406–410PubMedCrossRefGoogle Scholar
  73. Kalender WA, Felsenberg D, Louis O, Lopez P, Klotz E, Osteaux M, Fraga J (1989) Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Eur J Radiol 9: 75–80PubMedGoogle Scholar
  74. Kimmel DB (1981) A light microscopic description of osteoprogenitor cells of remodeling bone in the adult. Metab Bone Dis Rel Res 2S: 181–185Google Scholar
  75. Kleerekoper M, Villanueva AR, Staciu J, Sudhaker Rao D, Parfitt AM (1985) The role of the three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif Tissue Int 37:594–597PubMedCrossRefGoogle Scholar
  76. Kragstrup J, Meisen F (1983) Three dimensional morphology of trabecular bone osteons reconstructed from serial sections. Metab Bone Dis Rel Res 5:127–131CrossRefGoogle Scholar
  77. Kragstrup J, Gundersen HJG, Mosekilde L, Meisen F (1982) Estimation of the three dimensional wall thickness of completed remodeling sites in iliac trabecular bone. Metab Bone Dis Rel Res 4:113–119CrossRefGoogle Scholar
  78. Kragstrup J, Meisen F Mosekilde L (1983a) Thickness of lamellae in normal human iliac trabecular bone. Metab Bone Dis Rel Res 4:291–294CrossRefGoogle Scholar
  79. Kragstrup J, Meisen F, Mosekilde L (1983b) Thickness of bone formed at remodeling sites in normal iliac trabecular bone: variations with age and sex. Metab Bone Dis Rel Res 5:17–21CrossRefGoogle Scholar
  80. Lindsay R, Hart DM, Forrest C, Baird C (1980) Prevention of spinal osteoporosis in oophorectomized women. Lancet ii: 1151–1154CrossRefGoogle Scholar
  81. Lips P, Courpron P, Meunier PJ (1978) Mean wall thickness of trabecular bone packets. Metab Bone Dis Rel Res 2:13–17Google Scholar
  82. Marie PJ, Rasmussen H, Kuntz D (1985) Treatment of postmenopausal osteoporosis with phosphate and intermittent calcitonin. In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL (eds) Osteoporosis. Aalborg, Denmark, p 549Google Scholar
  83. Marotti G (1977) Decrement in volume of osteoblasts during osteon formation and its effect on the size of corresponding osteocytes. In: Meunier P (ed) Bone histomorphometry. Armour Montagu, Paris, p 385Google Scholar
  84. Mazess RB (1990) Fracture risk: a role for compact bone. Calcif Tissue Int 47: 191–193PubMedCrossRefGoogle Scholar
  85. Mellish RW, Garrahan NJ, Compston JE (1989) Age-related changes in trabecular width and spacing in human iliac crest biopsies. Bone Miner 6:331–338PubMedCrossRefGoogle Scholar
  86. Meisen F, Mosekilde L (1977) Morphometrie and dynamic studies of bone changes in hyperthyroidism. APMIS 85:141–150Google Scholar
  87. Meisen F, Mosekilde L (1978) Tetracycline double-labeling of iliac trabecular bone in 41 normal adults. Calcif Tissue Res 26:99–102CrossRefGoogle Scholar
  88. Meisen F, Mosekilde L (1980) Trabecular bone mineralization lag time determined by tetracycline double labeling in normal and certain pathological conditions. APMIS 88:83–88Google Scholar
  89. Meisen F, Nielsen HE (1977) Osteonecrosis following renal allotransplantation. APMIS 85:99–105Google Scholar
  90. Meisen F, Mosekilde L, Christensen MS (1977) Interrelationships between bone histomorphometry, S-iPTH and calcium-phosphorous metabolism in primary hyperparathyroidism. Calcif Tissue Res 24S: 16–22Google Scholar
  91. Meunier P, Vignon G, Bernard J, Edouard C, Courpron P, Porte J (1972) La lecture quantitative de la biopsie osseuse moyenne de diagnostic et d’étude de 106 hyperparathyroidies primitives, secondaires et paraneoplasiques. Rev Rhum Mal Osteoartic 39:635–643PubMedGoogle Scholar
  92. Meunier P, Coupron P, Edouard C, Bernard J, Bringuier J, Vignon G (1973a) Physiological senile involution and pathological rarefaction of bone. Clin Endocrinol Metabol 2:239–256CrossRefGoogle Scholar
  93. Meunier P, Bianchi CGS, Edouard C, Bernard JC, Courpron PM, Vignon G (1973b) Bone manifestations in thyrotoxicosis. Orthop Clin North Am 3:745–750Google Scholar
  94. Meunier P, Edouard C, Courpron P (1976) Morphometrie analysis of trabecular resorption surfaces in normal iliac bone. In: Jaworski ZFG (ed) Bone histo- morphometry. University of Ottawa Press, Ottawa, p 156Google Scholar
  95. Meunier PJ, Bressot C, Edouard CM (1978) Dynamics of bone remodeling in primary hyperparathyroidism. In: Copp DH, Talmage RV (eds) Endocrinology of calcium metabolism. Elsevier, Amsterdam, p 415Google Scholar
  96. Mosekilde L, Meisen F (1978) A tetracycline based histomorphomtric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism. Acta Med Scand 204:97–102PubMedCrossRefGoogle Scholar
  97. Mosekilde L, Meisen F, Bagger JP (1977a) Bone changes in hyperthyroidism: interrelationships between bone morphometry, thyroid function and calcium phosphorous metabolism. Acta Endocrinol 85:515PubMedGoogle Scholar
  98. Mosekilde L, Christensen MS, Lund B (1977b) The interrelationships between serum 25-hydroxycholecalciferol, serum parathyroid hormone and bone changes in anticonvulsant osteomalacia. Acta Endocrinol 84:559PubMedGoogle Scholar
  99. Mosekilde Li (1988) Age related changes in vertebral trabecular bone architecture assessed by a new method. Bone 9:247–250PubMedCrossRefGoogle Scholar
  100. Mosekilde Li (1990) Consequence of the remodeling process for vertebral trabecular bone structure: a scanning electron microscopy study. Bone Miner 10:13–35PubMedCrossRefGoogle Scholar
  101. Mosekilde Li, Mosekilde L (1986) Normal vertebral body size and compressive strength: relations to age and vertebral and iliac trabecular body compressive strength. Bone 7:207–212PubMedCrossRefGoogle Scholar
  102. Mosekilde Li, Mosekilde L (1988) Iliac crest trabecular bone volume as predictor for vertebral compressive strength, ash density and trabecular bone volume in normal individuals. Bone 9:195–199PubMedCrossRefGoogle Scholar
  103. Mosekilde Li, Mosekilde L (1990) Sex differences in age-related changes in vertebral body size, density and biomechanical competence in normal individuals. Bone 11:67–73PubMedCrossRefGoogle Scholar
  104. Mosekilde Li, Soegaard C (1990) Consequences of the remodeling process for vertebral trabecular structure and strength. In: Christiansen C, Overgaard K (eds) Osteoporosis 1990. 3rd international symposium on osteoporosis. Osteopress, Copenhagen, pp 607–609Google Scholar
  105. Munk Jensen N, Pors Nielsen S, Obel EB, Bonne Eriksen P (1988) Reversal of postmenopausal vertebral bone loss by oestrogen and progestagen: a double blind placebo controlled study. Br Med J 296:1150–1152CrossRefGoogle Scholar
  106. Neer R, Slovik D, Daly M, Lo C, Potts J, Nussbaum S (1990) Treatment of postmenopausal osteoporosis with daily parathyroid hormone plus calcitriol. Proceedings of the 3rd international symposium on osteoporosis. Osteopress, Copenhagen, pp 1314–1317Google Scholar
  107. Nilsson P, Meisen F, Malmaeus J, Danielson BG, Mosekilde L (1985) Relationships between bone aluminum and bone histomorphometry in patients on maintenance dialysis. Bone 6:21–27PubMedCrossRefGoogle Scholar
  108. Odgaard A, Jensen EB, Gundersen HJG (1990) Estimation of structural anisotropy based on volume orientation. A new concept. J Microsc 157:149–162PubMedCrossRefGoogle Scholar
  109. Owen M (1971) Cellular dynamics of bone. In: Bourne GH (ed) The biochemistry and physiology of bone, vol 3, 2nd edn. Academic, New York, p 255Google Scholar
  110. Parfitt AM (1979) Quantum concept of bone remodeling and turnover: implications for the pathogenesis of osteoporosis. Calcif Tissue Int 28:1–7PubMedCrossRefGoogle Scholar
  111. Parfitt AM (1980) Morphologic basis for bone mineral measurements: transient and steady state effects of treatment in osteoporosis. Miner Electrolyte Metab 4: 273–287Google Scholar
  112. Parfitt AM (1982) The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Metab Bone Dis Rel Res 4:1–2CrossRefGoogle Scholar
  113. Parfitt AM (1983) The physiologic and clinical significance of bone histomorphometric data. In: Recker RR (ed) Bone histomorphometry, techniques and interpreta- tion. CRC Press, Boca Raton, pp 143–223Google Scholar
  114. Parfitt AM (1984) Age related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tissue Int 36 [Suppl 1]: 123–128CrossRefGoogle Scholar
  115. Parfitt AM (1987) Trabecular bone architecture in the pathogenesis and prevention of fracture. Am J Med 82 1B:68–72CrossRefGoogle Scholar
  116. Parfitt AM, Villanueva AR, Mathew CHE, Aswani SA (1980) Kinetics of matrix and mineral apposition in osteoporosis and renal osteodystrophy. Relationship to rate of turnover and cell morphology. Metab Bone Dis Rel Res 2S:213–219Google Scholar
  117. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 72:1396–1409PubMedCrossRefGoogle Scholar
  118. Parfitt AM, Rao DS, Stanciu J, Villanueva AR, Kleerekoper M, Frame B (1985) Irreversible bone loss in osteomalacia. J Clin Invest 76:2403–2412PubMedCrossRefGoogle Scholar
  119. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche HM, Meunier P, Ott SM, Recker RR (1987) Bone histomorphomtry: standardization of nomencla- ture, symbols and units. J Bone Miner Res 2:595–610PubMedCrossRefGoogle Scholar
  120. Parisien MV, McMahon D, Pushparaj N, Dempster DW (1988) Trabecular architec- ture in iliac crest bone biopsies: intra-individual variability in structural param- eters and changes with age. Bone 9:289–295PubMedCrossRefGoogle Scholar
  121. Pesch HJ, Henschke F, Seibold H (1977) Einfluss von Mechanik und Alter auf den Spongiosaumbau in Lendenwirbelkörpern und im Schenkelhals. Eine Strukturanalyse. Virchows Arch [A] 377:27–42CrossRefGoogle Scholar
  122. Pilbeam CC, Raisz LG (1988) In vitro inhibition of PTH stimulated prostaglandin E2 production by 17–beta estradiol. J Bone Miner Res 3:S219Google Scholar
  123. Pirok DJ, Ramser JR, Takahashi H, Vilanueva AT, Frost HM (1966) Normal histological tetracycline and dynamic parameters in human mineralized bone sections. Henry Ford Hosp Med Bull 14:195–218Google Scholar
  124. Pødenphant J, Christiansen C (1988) The value of iliac crest biopsy in spinal osteoporosis. A critical view. In: Christiansen C (ed) Osteoporosis. Aalborg, Denmark, p 735Google Scholar
  125. Podenphant J, Gotfredsen A, Nilas L, Norgârd H, Brændstrup O (1986) Iliac crest biopsy: representativity for the amount of mineralized bone. Bone 7:427–430PubMedCrossRefGoogle Scholar
  126. Preteux F, Bergot C, Laval-Jeantet AM (1985) Automatic quantification of vertebral cancellous bone remodeling during aging. Anat Clin 7:203–208PubMedCrossRefGoogle Scholar
  127. Rao DS, Villanueva AR, Mathews M (1983) Histologic evolution of vitamin D depletion in patients with intestinal malabsorption or dietary deficiency. In: Frame B, Potts JT (eds) Clinical disorders of bone and mineral metabolism. Exerpta Medica, Amsterdam, pp 224–226Google Scholar
  128. Reeve J (1986) A stochastic analysis of iliac trabecular bone dynamics. Clin Orthop 213:264–278PubMedGoogle Scholar
  129. Reeve J, Arlot M, Bernard M, Charhon S, Edouard C, Slovik D, Visman FJ, Meunier PJ (1981) Calcium-47 kinetic measurements of bone turnover com- pared to bone histomorphometry in osteoporosis: the influence of human parathyroid fragment (hPTH 1–34) therapy. Metab Bone Dis Rel Res 3:23–30CrossRefGoogle Scholar
  130. Reeve J, Podbesek TR, Price M (1985) Studies on a “short cycle” ADFR regime using parathyroid peptide hPTH 1–34 in idiopathic osteoporosis and in a dog model. In: Christiansen C, Arnaud CD, Nordin BEC, Parfitt AM, Peck WA, Riggs BL (eds) Osteoporosis. Proceedings of the international symposium on osteoporosis. Osteopress, Copenhagen, p 567Google Scholar
  131. Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ III (1981) Differential changes in bone mineral density of the appendicular and axial skeleton with aging. J Clin Invest 67:328–335PubMedCrossRefGoogle Scholar
  132. Riggs BL, Hodgson SF, O’Fallon WM, Chao EYS, Wahner HW, Muhs JM, Cedel SL, Melton LJ III (1990) Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 332:802–809CrossRefGoogle Scholar
  133. Rockoff SD, Zettner A, Albright J (1967) Radiographic trabecular quantitation of human lumbar vertebrae in situ: II. Relation to bone quantity, strength and mineral content (preliminary results). Invest Radiol 2:339–352PubMedCrossRefGoogle Scholar
  134. Rockoff SD, Sweet E, Bleustein J (1969) The relative contribution of trabecular and cortical bone to strength of human lumbar vertebrae. Calcif Tissue Res 3: 163–175PubMedCrossRefGoogle Scholar
  135. Sedlin ED (1964) The ratio of cortical area to total cross section area in rib diaphysis. A quantitative index of osteoporosis. Clin Orthop 36:161–168Google Scholar
  136. Sedlin ED, Frost HM, Villanueva AR (1963) Variations in cross–section area of rib cortex with age. J Gerontol 18:9–13PubMedGoogle Scholar
  137. Sherrard DJ, Baylink DJ, Wergedal JE, Maloney NA (1974) Quantitative histological studies on the pathogenesis of uremic bone disease. J Clin Endocrinol Metab 39:119–136PubMedCrossRefGoogle Scholar
  138. Steiniche T, Hasling C, Charles P, Eriksen EF, Meisen F, Mosekilde L (1989) A randomized study on the effects of estrogen/gestagen or high dose calcium on trabecular bone remodeling in postmenopausal osteoporosis. Bone 10:313–320PubMedCrossRefGoogle Scholar
  139. Steiniche T, Häsling C, Charles P, Eriksen EF, Mosekilde L, Meisen F (1991) The effects of ethidronate on trabecular bone remodeling in postmenopausal spinal osteoporosis: A randomized study comparing intermittent treatment and an ADFR regime. Bone 12:155–164PubMedCrossRefGoogle Scholar
  140. Storm T, Thamsborg G, Steiniche T, Genant HK, Sorensen OH (1990) Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 322:1265–1271PubMedCrossRefGoogle Scholar
  141. Twomey L, Taylor J, Furniss B (1983) Age changes in the bone density and structure of the lumbar vertebral column. J Anat 136:15–25PubMedGoogle Scholar
  142. Vesterby A (1990) Star volume of marrow space and trabeculae in iliac crest: sampling procedure and correlation to star volume of first lumbar vertebra. Bone 11:149–155PubMedCrossRefGoogle Scholar
  143. Vesterby A, Kragstrup J, Gundersen HJG, Meisen F (1987a) Unbiased stereological estimation of surface density in bone using vertical sections. Bone 8:13–17PubMedCrossRefGoogle Scholar
  144. Vesterby A, Gundersen HJG, Meisen F (1987b) Unbiased stereological estimation of osteoid and resorption, fractional surfaces in trabecular bone using vertical sections: sampling efficiency and biological variation. Bone 8:333–337PubMedCrossRefGoogle Scholar
  145. Vesterby A, Gundersen HJG, Meisen F, Mosekilde L (1989a) Normal post- menopausal women show iliac crest trabecular thickening on vertical sections. Bone 10:333–340PubMedCrossRefGoogle Scholar
  146. Vesterby A, Gundersen HJG, Meisen F (1989b) Star volume of marrow space and trabeculae of first lumbar vertebra: sampling efficiency and biological variation. Bone 10:7–13PubMedCrossRefGoogle Scholar
  147. Vesterby A, Gundersen HJG, Meisen F, Mosekilde L (1991a) Marrow space star volume in iliac crest decreases in osteoporotic patients after continuous treat- ment with fluoride, calcium and vitamin D2 for five years. Bone 12:33–37PubMedCrossRefGoogle Scholar
  148. Vesterby A, Mosekilde Li, Gundersen HJG, Meisen F, Mosekilde Le, Holme K, Sørensen L (1991b) Biologically meaningful determinants for the in-vitro strength of lumbar vertebra. Bone 12:219–224PubMedCrossRefGoogle Scholar
  149. Vogel M, Hahn M, Caselitz P, Woggan J, Pompesius-Kempa P, Delling G (1990) Comparison of trabecular bone structure in man today and an ancient popula- tion in Western Germany. In: Takahashi HE (ed) Proceedings of the 5th international workshop on bone histomorphometry. Smith–Gordon, Nishimura, pp 220–223Google Scholar
  150. Wakamatsu E, Sissons HA (1969) The cancellous bone of the iliac crest. Calcif Tissue Res 4:147–161PubMedCrossRefGoogle Scholar
  151. Weaver JK, Chalmers J (1966) Cancellous bone: its strength and changes with aging and an evaluation of some methods for measuring its mineral content. J Bone Joint Surg [Am] 48:289–299Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • E. F. Eriksen
  • A. Vesterby
  • M. Kassem
  • F. Melsen
  • L. Mosekilde

There are no affiliations available

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