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Physiology and Pharmacology of Bone pp 507–567Cite as

Parathyroid Hormone: Biosynthesis, Secretion, Chemistry, and Action

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 107))

Abstract

The parathyroid hormone (PTH) story was once fairly simple. PTH raises blood calcium by resorbing bone, conserving urinary calcium, and activating vitamin D in order to increase intestinal calcium absorption. Blood calcium, in turn, decreases PTH secretion. The PTH-calcium homeostatic loop acts to maintain a constant level of blood calcium in the face of varying dietary and skeletal demands. This physiologically appealing story remains a powerful organizing principle for understanding parathyroid function, but has been modified by important observations in the last few years.

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Kronenberg, H.M. et al. (1993). Parathyroid Hormone: Biosynthesis, Secretion, Chemistry, and Action. In: Physiology and Pharmacology of Bone. Handbook of Experimental Pharmacology, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77991-6_15

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