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The Microcirculation in Cardiac Hypertrophy

  • Conference paper
Idiopathic Dilated Cardiomyopathy

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Abstract

Left ventricular hypertrophy has long been associated with increased risk of fatal and nonfatal cardiovascular events. In the Framingham experience, individuals with EKG evidence of left ventricular hypertrophy had an approximately five fold increased risk of death, new onset of angina pectoris, or nonfatal myocardial infarction [23]. Recent studies have shown that over one-third of hypertensive patients have measurable increases in left ventricular mass, even if the EKG is normal [13, 15]: these patients also represent a high-risk group for cardiovascular events [11, 26]. Several observations in humans with left ventricular hypertrophy, whether primary (e.g., hypertrophic cardiomyopathy) or secondary (e.g., hypertension, aortic stenosis) suggest that myocardial ischemia may mediate many of these events, such as complaints of anginalike chest pain, often with abnormal noninvasive testing similar to that seen in patients with coronary artery disease [9, 19, 28, 53]. Because epicardial coronary arteries commonly appear normal during angiography, consideration has been made that the coronary microcirculation may be abnormal in structure or function in patients with left ventricular hypertrophy.

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Authors and Affiliations

  1. Cardiovascular Diagnosis Section Cardiology Branch, NHLBI National Institutes of Health Bethesda, MD, 20892, USA

    R. O. Cannon III

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  1. R. O. Cannon III
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Editors and Affiliations

  1. Medizinische Klinik und Poliklinik, Postfach 3742, W-3400, Göttingen, Fed. Rep. of Germany

    Hans-Reiner Figulla

  2. Institut für Pathologie, Universität Tübingen, W-7400, Tübingen, Fed. Rep. of Germany

    Reinhard Kandolf

  3. Max-Planck-Institut für Biochemie, W-8033, Martinsried, Fed. Rep. of Germany

    Reinhard Kandolf

  4. Department of Pathology and Microbiology, University of Nebraska, Medical Center, 600 South 42nd Street, Omaha, NE, 68198-6495, USA

    Bruce McManus Ph.D., M.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Cannon, R.O. (1993). The Microcirculation in Cardiac Hypertrophy. In: Figulla, HR., Kandolf, R., McManus, B. (eds) Idiopathic Dilated Cardiomyopathy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77891-9_17

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  • DOI: https://doi.org/10.1007/978-3-642-77891-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77893-3

  • Online ISBN: 978-3-642-77891-9

  • eBook Packages: Springer Book Archive

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