Neuropeptides and Merkel Cells in Tissue Expansion

  • U. Wollina
  • U. Berger
Conference paper


Tissue expansion has become a widely used method in plastic and reconstructive surgery (for overview see: Baker 1991; Mackay et al. 1989; Table 1). A silicone prosthesis is implanted under the skin. After 1 or 2 weeks, the expansion is started by controlled injection of saline solution. Particular attention must be paid to the pO2 and to the dermal blood flow (Berger and Hyckel 1989; Berger et al. 1991). The dermal tissue becomes rearranged under stretching conditions. The epidermis responds with a temporary thinning of the papillary layer and a decrease in the length of rete ridges (Johnson et al. 1988; Leighton et al. 1988). The surplus of skin which is achieved at the end of treatment can be used to cover defects or reconstruct tissue.


Vasoactive Intestinal Peptide Skin Flap Vasoactive Intestinal Polypeptide Tissue Expansion Porcine Skin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • U. Wollina
    • 1
  • U. Berger
    • 1
  1. 1.Departments of Dermatology and Plastic SurgeryFriedrich Schiller University JenaJenaGermany

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