Abstract
Granulocytes (polymorphonuclear leukocytes, PMNs) and monocytes/ macrophages are important in wound healing. Within the first few hours PMNs and monocytes begin to infiltrate sites of injury. The major function of PMNs is to kill microbes and phagocytose cellular debris so that healing can proceed [1]. Monocytes/macrophages invading the wound are also active in phagocytosis. In addition they release a number of cytokines including growth factors, interleukin-8 (IL-8), and tumor necrosis factor (TNF-α) needed for new tissue formation and shown to stimulate PMNs [1–3].
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References
Clark RAF (1991) Cutaneous wound repair: a review with emphasis on integrin receptor expression. In: Janssen H, Rooman R, Robertson JIS (eds) Wound healing. Wrightson Biomedical, Petersfield, UK, pp 7–17.
Schopf RE, Keller R, Rehder M, Benes P, Kallinowski F, Vaupel P (1990) TNFα primes polymorphonuclear leukocytes for an enhanced respiratory burst to a similar extent as bacterial lipopolysaccharide. J Invest Dermatol 95:216S–218S.
Schröder J-M, Persoon NLM, Christophers E (1990) Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. J Exp Med 171:1091–1100.
Gillissen G, Kühne F-W, Breuer-Werle M, Melzer B, Ostendorp H (1986) Increased resistance towards two systemic experimental infections by tetrachorodecaoxygen anion complex. Arzneimittelforschung/Drug Res 36:1778–1782.
Hinz J, Hautzinger H, Stahl K-W (1986) Rationale for and results from a randomised, double-blind trial of tetrachlorodecaoxygen anion complex in wound healing. Lancet: 825-828.
Zenker W, Thiede A, Dommes M, Ullmann U (1986) Die Wirksamkeit von Tetrachlorodecaoxid (TCDO) zur Behandlung komplizierter Wundheilungsstörungen. Chirurg 57:334–339.
Youngman RJ, Wagner GR, Kühne FW, Elstner EF (1985) Biochemical oxygen activation as the basis for the physiological action of tetrachlorodecaoxide (TCDO). Z Naturforsch 40c:409–414.
Babior BM (1978) Oxygen-dependent microbial killing by phagocytes. N Engl J Med 298:659–668, 721-725
Schopf RE, Mattar J, Meyenburg W, Scheiner O, Hammann KP, Lemmel E-M (1984) Measurement of the respiratory burst in human monocytes and polymorphonuclear leukocytes by nitro blue tetrazolium reduction and chemiluminescence. J Immunol Methods 67:109–117.
Böyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest [Suppl] 97:77–89.
Ullmann U, Kühne FW (1984) In vitro investigations on the antibacterial action and the influence on the phagocytic chemiluminescence of tetrachlorodecaoxide — a new, nonmetallic oxygen complex. Infection 12:225–229.
Schopf RE, Hammann KP, Scheiner O, Lemmel E-M, Dierich MP (1982) Activation of human monocytes by both human α1H and C3b. Immunology 46:307–312.
Kapp A, Zeck-Kapp G (1990) Activation of the oxidative metabolism in human polymorphonuclear neutrophilic granulocytes: the role of immuno-modulating cytokines. J Invest Dermatol 95:94S–99S.
Oppenheim JJ, Ruscetti FW, Faltynek C (1991) Cytokines. In: Stites DP, Terr AI (eds) Basic and clinical immunology. Prentice Hall, Appleton and Lange, East Norwalk, pp 78–100.
Mueller-Klieser W, Vaupel P (1985) Improvement of tumor spheroid oxygenation by tetrachlorodecaoxide. Int J Radiat Oncol Biol Phys 13:49–54.
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© 1995 Springer-Verlag Berlin Heidelberg
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Schopf, R.E., Hermann, G.A., Hinz, J., Morsches, B. (1995). Granulocyte Activity Is Enhanced by Culture Supernatants of Mononuclear Leukocytes Incubated with Tetrachlorodecaoxide. In: Altmeyer, P., Hoffmann, K., el Gammal, S., Hutchinson, J. (eds) Wound Healing and Skin Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77882-7_30
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DOI: https://doi.org/10.1007/978-3-642-77882-7_30
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