Design of Novel Bioreductive Drugs
There is currently a great need and indeed considerable enthusiasm to search for new drug molecules with improved therapeutic selectivity in the major solid tumours. One approach is to screen novel structures for activity in biologically relevant models. This is the new approach taken by the United States National Cancer Institute which places much emphasis on panels of human cell lines to test natural products in vitro. An alternative strategy is to identify differences in biochemical structure and function between normal and neoplastic cells and to develop agents to exploit these novel targets on a rational basis. There are many new and exciting possibilities. The elaboration of agents which interfere with oncogene function, growth factors and their receptors, transmembrane signal transduction and so on, are good examples. Considerable attention is also being directed towards another exploitable target based on the aberrant physiology of solid tumours: cellular hypoxia .
KeywordsTumour Hypoxia Hypoxic Cell Cytochrome P450 Reductase Mouse Liver Microsome Flavone Acetic Acid
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