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Antisense and Antigene Oligonucleotides Targeted to Oncogenes

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New Approaches in Cancer Pharmacology: Drug Design and Development

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

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Abstract

Cell transformation leading to tumour development is a multistep process involving the activation of growth-stimulatory pathways (under the control of oncogenes) and the in-activation of growth-inhibitory pathways (under the control of tumour-suppressor genes). Inhibition of oncogenes and/or stimulation of tumour-suppressor genes represent new strategies that should lead i) to a better understanding of the different steps involved in tumourigenesis, and ii) to the development of new therapeutic approaches.

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Authors and Affiliations

  1. Laboratoire de Biophysique, Muséum National d’Histoire Naturelle, INSERM U.201 — CNRS UA.481, 43 Rue Cuvier, 75005, Paris, France

    Claude Hélène

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  1. Claude Hélène
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Editors and Affiliations

  1. Cancer Research Campaign Beatson Laboratories, CRC Department of Medical Oncology, University of Glasgow, Alexander Stone Building, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK

    Paul Workman (Chairman and Editor) (Chairman and Editor)

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© 1992 Springer-Verlag Berlin Heidelberg

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Hélène, C. (1992). Antisense and Antigene Oligonucleotides Targeted to Oncogenes. In: Workman, P. (eds) New Approaches in Cancer Pharmacology: Drug Design and Development. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77874-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-77874-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77876-6

  • Online ISBN: 978-3-642-77874-2

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