Skip to main content

Percutaneous Alcoholization of Adenomatous Hyperplastic Nodules in Cirrhosis

  • Conference paper
Book cover Lebertumoren und portale Hypertension

Abstract

Cirrhotic patients, a high-risk group for the development of hepatocellular carcinoma (HCC), have been followed largely with ultrasonographic (US) monitoring and serum alpha fetoprotein (AFP) measurements to detect small HCC in preclinical stage (Okuda 1986 a; Cottone et al. 1988; Oka et al. 1990). However, the widespread use of US studies has also led to increased detection of nonneoplastic lesions of the cirrhotic liver. Among these, the adenomatous hyperplastic nodules (AHNs), considered likely to evolve as HCC, are the most frequent (Arakawa et al. 1986 a, b; Okuda 1986 b; Ohta and Nakanuma 1987; Tsuda et al. 1988; Sakamoto et al. 1991).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arakawa M, Sugihara S, Kenmochi K et al. (1986 a) Small mass lesions in cirrhosis: transition from benign adenomatous hyperplasia to hepatocellular carcinoma? J Gastroenterol Hepatol 1:3–14

    Article  Google Scholar 

  • Arakawa M, Kage M, Sugihara S et al. (1986b) Emergence of malignant lesion within an adenomatous hyperplastic nodule in a cirrhotic liver. Gastroenterology 91:198–208

    PubMed  CAS  Google Scholar 

  • Cottone M, Turri M, Caltagirone M et al. (1988) Early detection of hepatocellular carcinoma associated with cirrhosis by ultrasound and alpha-fetoprotein: a prospective study. Hepatogastroenterology 35:101–103

    PubMed  CAS  Google Scholar 

  • Ebara M, Ohto M, Sugiura N et al. (1990) Percutaneous ethanol injection for the treatment of small hepatocellular carcinoma: study of 95 patients. J Gastroenterol Hepatol 5: 616–626

    Article  PubMed  CAS  Google Scholar 

  • Edmonson HA (1958) Tumors of the liver and intrahepatic bile ducts: atlas of tumor pathology. Fasc 25. Armed Forces Institute of Pathology, Washington

    Google Scholar 

  • Furuya K, Nakamura M, Yamamoto Y (1988) Macroregenerative nodule of the liver: a clinicopathologic study of 345 autopsy cases of chronic liver disease. Cancer 61:99–105

    Article  PubMed  CAS  Google Scholar 

  • Kinami Y, Takashima S, Miyazak I (1986) Hepatic resection for hepatocellular carcinoma associated with liver cirrhosis. World J Surg 10:294–301

    Article  PubMed  CAS  Google Scholar 

  • Kondo F, Ebara M, Sugiura N et al. (1990) Histological features and clinical course of large regenerative nodules: evaluation of their precancerous potentiality. Hepatology 12/3:592–598

    Article  PubMed  CAS  Google Scholar 

  • Lee CS, Sung JL, Hwang LY et al. (1986) Surgical treatment of 109 patients with symptomatic and asymptomatic hepatocellular carcinoma. Surgery 99:481–490

    PubMed  CAS  Google Scholar 

  • Livraghi T, Vettori C (1990) Percutaneous ethanol injection therapy of hepatoma. Cardiovasc Intervent Radiol 13:146–152

    Article  PubMed  CAS  Google Scholar 

  • Livraghi T, Festi D, Monti F et al. (1986) US-guided percutaneous ethanol injection of small hepatic and abdominal tumors. Radiology 161:309–312

    PubMed  CAS  Google Scholar 

  • Livraghi T, Salmi A, Bolondi L et al. (1988) Small hepatocellular carcinoma: percutaneous alcohol injection - results in 23 patients. Radiology 168:313–317

    PubMed  CAS  Google Scholar 

  • Livraghi T, Sangalli G, Vettori C (1989) Adenomatous hyperplastic nodules in the cirrhotic liver: a therapeutic approach. Radiology 170:155–157

    PubMed  CAS  Google Scholar 

  • Nagasue N, Akamizu H, Yukaya H et al. (1984) Hepatocellular pseudotumor in the cirrhotic liver. Cancer 54:2487–2494

    Article  PubMed  CAS  Google Scholar 

  • Ohta G, Nakanuma Y (1987) Comparative study of three nodular lesions in cirrhosis: adenomatoid hyperplasia, adenomatoid hyperplasia with intermediate lesion and small hepatocellular carcinoma. In: Okuda K, Ishak KG (eds) Neoplasms of the liver. Springer, Berlin Heidelberg New York, pp 177–188

    Google Scholar 

  • Oka H, Kuriola N, Kim K et al. (1990) Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis. Hepatology 12:680–687

    Article  PubMed  CAS  Google Scholar 

  • Okuda K (1986a) Early recognition of hepatocellular carcinoma. Hepatology 6:729–738

    Article  PubMed  CAS  Google Scholar 

  • Okuda K (1986 b) What is the precancerous lesion for hepatocellular carcinoma in man? J Gastroenterol Hepatol 1:79–85

    Article  Google Scholar 

  • Rapaccini GL, Pompili M, Caturelli E et al. (1990) Focal ultrasound lesions in liver cirrhosis diagnosed as regenerating nodules by fine-needle biopsy: follow-up of 12 cases. Dig Dis Sci 35/4:422–427

    Article  PubMed  CAS  Google Scholar 

  • Sakamoto M, Hirohashi S, Shimosato Y (1991) Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 22:172–178

    Article  PubMed  CAS  Google Scholar 

  • Sheu JC, Sung JL, Huang GT et al. (1987) Intratumor injection of absolute ethanol under ultrasound guidance for the treatment of small hepatocellular carcinoma. Hepatogastroenterology 34:255–261

    PubMed  CAS  Google Scholar 

  • Shüna S, Yasuda H, Muto H et al. (1987) Percutaneous ethanol injection in the treatment of liver neoplasms. AJR Am J Roentgenol 149:949–952

    PubMed  CAS  Google Scholar 

  • Shüna S, Tagawa K, Unuma T et al. (1990) Percutaneous ethanol injection therapy for the treatment of hepatocellular carcinoma. AJR Am J Roentgenol 154:947–951

    PubMed  CAS  Google Scholar 

  • Sironi S, Livraghi T, Del Maschio A (1991) Small hepatocellular carcinoma treated with percutaneous ethanol injection: MR imaging findings. Radiology 180:333–336

    PubMed  CAS  Google Scholar 

  • Tsuda H, Hirohashi S, Shiosato Y et al. (1988) Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma. Gastroenterology 95: 1664–1666

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Lencioni, R., Caramella, D., Bagnolesi, P., Cilotti, A., Di Coscio, G., Bartolozzi, C. (1993). Percutaneous Alcoholization of Adenomatous Hyperplastic Nodules in Cirrhosis. In: Reiser, M., Steudel, A., Hirner, A., Kania, U. (eds) Lebertumoren und portale Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77834-6_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77834-6_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77835-3

  • Online ISBN: 978-3-642-77834-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics