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Grundlagen der immunologischen und biochemischen Modulation von Zytostatika

  • Conference paper
Immuntherapie in der Uroonkologie

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Zusammenfassung

Die Kombination von Zytokinen und Zytostatika stellt einen neuen Ansatz in der Behandlung maligner Erkrankungen mit dem Ziel dar, den therapeutischen Index zu erhöhen. Gesicherte Konzepte für eine optimale Kombination dieser Substanzgruppen existieren bislang nicht. Deshalb sollten die molekularen Interaktionsmechanismen zwischen Zytokinen und Zytostatika bekannt sein, damit klinische Studien rational konzipiert werden können. Da die Wirkung von Zytostatika durch verschiedene Zytokine verstärkt werden kann, scheinen die Interaktionen auf verschiedenen Ebenen zu erfolgen: Änderung der Zytostatikaaufnahme in die Zelle, Änderung der Aktivität von Targetenzymen des Zytostatikametabolismus und Beeinflussung der Pharmakokinetik von Zytostatika durch Zytokine. Die Analyse der Interaktionen zwischen Zytokinen und Zytostatika wird darüber hinaus durch die immunmodulatorischen und proliferationsmodulierenden Effekte von Zytokinen erschwert. Ein Mechanismus der synergistischen Interaktion zwischen Interferon (IFN) und 5-Fluorouracil (5-FU) scheint auf einer Erhöhung aktiver Metabolite von 5-FU zu beruhen. Darüber hinaus kann IFN die Entwicklung einer Resistenz gegen 5-FU dadurch verhindern, daß eine Überexpression der Thymidylat-Synthetase blockiert wird. Das Fehlen zytokinetischer Effekte von IFN und 5-FU spricht gegen ein Recruitment von Zellen aus der Go-Phase in den Zellzyklus.

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Author information

Authors and Affiliations

  1. Abteilung Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Universitätsklinikum Steglitz, Freie Universität, Berlin, Deutschland

    E. D. Kreuser & E. Thiel

  2. Department of Qncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA

    S. Wadler

Authors
  1. E. D. Kreuser
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  2. S. Wadler
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  3. E. Thiel
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Editors and Affiliations

  1. Urologische Klinik und Poliklinik, Universitätsklinikum Essen, Hufelandstr. 55, W-4300, Essen 1, Deutschland

    Herbert Rübben  & Mark Goepel  & 

  2. Urologische Universitätsklinik, Moorenstr. 5, W-4000, Düsseldorf 1, Deutschland

    Bernd J. Schmitz-Dräger

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© 1993 Springer-Verlag Berlin Heidelberg

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Kreuser, E.D., Wadler, S., Thiel, E. (1993). Grundlagen der immunologischen und biochemischen Modulation von Zytostatika. In: Rübben, H., Goepel, M., Schmitz-Dräger, B.J. (eds) Immuntherapie in der Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77830-8_25

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  • DOI: https://doi.org/10.1007/978-3-642-77830-8_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77831-5

  • Online ISBN: 978-3-642-77830-8

  • eBook Packages: Springer Book Archive

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