Skip to main content

Ist die Behandlung mit BCG eine Immuntherapie?

  • Conference paper
Immuntherapie in der Uroonkologie
  • 20 Accesses

Zusammenfassung

Die Verabreichung des Impfstoffs Bacille-Calmette-Guérin (BCG) führt zu einer Stimulation des Immunsystems (Davies 1982); doch stellt sich die Frage, ob die vorteilhafte antitumorale Wirkung der intravesikalen BCG-Behandlung immunologischer Art ist und welche Immunmechanismen an dieser Reaktion beteiligt sind. Dies kann zur Lösung praktischer Probleme wie der Wahl des optimalen Behandlungsverlaufs und Indikation zur Fortführung der Therapie beitragen.

Übersetzung aus dem Engl, von Belinde Junkers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alroy J, Pauli BU, Hayden JE, Gould VE (1979) Cytoplasmic lumina in bladder carcinomas. Hum Pathol 10: 549–555

    Article  PubMed  CAS  Google Scholar 

  • Bast RC, Zbar B, Borsos T, Rapp HJ (1974) BCG and cancer (2 parts). N Engl J Med 290: 1413–1420

    Article  PubMed  Google Scholar 

  • Bast RC, Zbar B, Borsos T, Rapp HJ (1974) BCG and cancer (2 parts). N Engl J Med 290: 1458–1469 Thoa290: 1458–1469

    Article  PubMed  Google Scholar 

  • Becich MJ, Carroll S, Ratliff TL (1991) Internalization of bacille Calmette Guerin by bladder tumour cells. J Urol 145: 1316–1324

    PubMed  CAS  Google Scholar 

  • Böhle A, Nowc Ch, Ulmer AJ, Musehold J, Gerdes J, Hofstetter AG, Flad H-D (1990) Elevations of cytokines interleukin-1, interleukin-2 and tumour necrosis factor in the urine of patients after intravesical bacillus Calmette Guerin immunotherapy. J Urol 144: 59–64

    PubMed  Google Scholar 

  • Coe JE, Feldman JD (1966) Extracutaneous delayed hypersensitivity, particularly in the guinea-pig bladder. Immunology 10 (2): 127–36

    PubMed  CAS  Google Scholar 

  • Connolly JG (1983) Letter to Editor re Immunotherapy of superficial bladder cancer. J Urol 130: 368

    PubMed  CAS  Google Scholar 

  • Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ (1984 a) The detailed distribution of HLA-ABC antigens in normal human organs Transplantation 38: 287–292

    Article  PubMed  CAS  Google Scholar 

  • Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ (1984 a) The detailed distribution of MHC Class II antigens in normal human organs. Transplantation 38: 293–297 ThoaThe detailed distribution of MHC Class II antigens in normal human organs. Transplantation 38: 293–297

    Article  PubMed  CAS  Google Scholar 

  • Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ (1984b) The detailed distribution of MHC Class II antigens in normal human organs. Transplantation 38: 293–297

    Article  PubMed  CAS  Google Scholar 

  • Davies M (1982) Bacillus Calmette Guerin as an anti tumour agent: the interaction with cells of the mammalian immune system. Biochim Biophys Acta 651: 143–174

    PubMed  CAS  Google Scholar 

  • Hanna MG, Zbar B, Rapp HJ (1972) Histopathology of tumour regression after intralesional injection of Mycobacterium bovis ii, Comparative effects of Vaccinia virus, Oxalozone and Turpentine. J Natl Cancer Inst 48: 1697–1703

    PubMed  CAS  Google Scholar 

  • Hawkyard SJ, James K, Prescott S, Jackson AM, Ritchie AWS, Chisholm GD (1991) The effects of recombinant interferon-gamma on a panel of human bladder cancer cell lines. J Urol 145: 1078–1081

    PubMed  CAS  Google Scholar 

  • Hawkyard SJ, James K, Prescott S, Jackson AM, Ritchie AWS, Chisholm GD (1992) The growth inhibitory effects of interferon gamma on bladder cancer cells. J Urol 147: 1399–1403

    PubMed  CAS  Google Scholar 

  • Kelley DR, Haaff EO, Becich M, Lage J, Bauer WC, Dresner SM, Catalona WJ, Ratliff TL (1985) Prognostic value of purified protein derivative skin test and granuloma formation in patients treated with intravesical Bacillus Calmette-Guérin. J Urol 135: 268–271

    Google Scholar 

  • Leake ES, Ockers JR, Myrvik QN (1976) In vitro interactions of the BCG and Ravenol strains of Mycobacterium bovis with rabbit macrophages: adherence of the phagosomal membrane to the bacterial cell wall and the problem of the peribacillary space. J Reticuloendothelial Soc 22: 129–147

    Google Scholar 

  • Prescott S, James K, Hargreave TB, Busutti A, Chisholm GD, Smyth JF (1989) HLA-DR expression by high grade superficial bladder cancer treated with BCG. Br J Urol 63: 264–269

    Article  PubMed  CAS  Google Scholar 

  • Prescott S, James K, Hargreave TB, Chisholm GD, Smyth JF (1990) Radio-immunoassay detection of interferon-gamma in urine after intravesical Evans BCG therapy. J Urol 144: 1248–1251

    PubMed  CAS  Google Scholar 

  • Prescott S, James K, Hargreave TB, Chisholm GD, Smyth JF (1992) Intravesical Evans strain BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall. J Urol 147, 1636–1642

    PubMed  CAS  Google Scholar 

  • Ratliff TL, Gillen D, Catalona WJ (1987) Requirement of a thymus dependent immune response for BCG mediated antitumour activity. J Urol 137: 155–158

    PubMed  CAS  Google Scholar 

  • Rooke GAW, Steele J, Fraher L, Barker S, Karmali R, O’Riordan J, Stanford J (1986) Vitamin D3, gamma interferon and control of proliferation of Mycobacterium tuberculosis by human monocytes Immunology 57: 159

    Google Scholar 

  • Sarzotti M, Baron S, Tyring SK, Klimpel GR (1986) Interferon mediated protection of B16melanoma cells from cytotoxicity by activated macrophages. Cell Immunol 100: 280–287

    Article  PubMed  CAS  Google Scholar 

  • Schamhart DHJ, Kurth K (1990) Detection of urinary IL-6 during intravesical BCG therapy. J Urol 143: 321A (Abstr 531)

    Google Scholar 

  • Schwartz R, Momburg F, Moldenhauer G, Dörken B, Schirrmacher V (1985) Induction of HLA Class II antigen expression on human carcinoma cell lines by interferon-gamma. Int J Cancer 35: 245–250

    Article  PubMed  CAS  Google Scholar 

  • Spector WG, Marianayagam Y, Ridley MJ (1982) The role of antibody in primary and reinfection BCG granulomas of rat skin. Journal of Pathology 136 (1): 41–57

    Article  PubMed  CAS  Google Scholar 

  • Trinchieri G, Perussia B (1985) Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 6: 131–136

    Article  CAS  Google Scholar 

  • Welsh RM, Karre K, Hanson M, Kunkel LA, Kiessling RW (1981) Interferon mediated protection of normal and tumour target cells aginst lysis by mouse natural killer cells. J Immunol 126: 219–225

    PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Docherty PC (1979) MHC cytotoxicT-cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function and responsiveness. Adv Immunol 27: 51–177

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Prescott, S., Hawkyard, S.J., Jackson, A.M., James, K., Chisholm, G.D. (1993). Ist die Behandlung mit BCG eine Immuntherapie?. In: Rübben, H., Goepel, M., Schmitz-Dräger, B.J. (eds) Immuntherapie in der Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77830-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77830-8_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77831-5

  • Online ISBN: 978-3-642-77830-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics