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Zellbewegung und Metastasierung: Über die Rolle des Rezeptors des autokrinen Motilitätsfaktors bei Tumorzellen

  • S. Silletti
  • A. Raz
Conference paper

Zusammenfassung

Die aktive Bewegung durch invadierende Tumorzellen wird als Voraussetzung für die Entstehung von sekundären Neoplasmen angesehen. Der Erfolg einer Metastasierung setzt die Invasion in das umgebende Normalgewebe sowie das Überschreiten der Gefäß- und/oder lymphatischen Grenzen voraus (Nicolson 1988; Fidler 1989). Es wurde vorgeschlagen, daß die Motilität von einzelnen Zellen oder Zellgruppen am Leitsaum einer Tumorprotrusion für eine solche invasive Bewegung verantwortlich sein könnte (Strauli u. Weis 1977). Die Analyse der früher bereits charakterisierten hoch- und niedrig-metastatischen, abgewandelten Subpopulationen zeigte, daß niedrigmeta-statische Zellen weitestgehend unbeweglich sind, während ihre hochmeta-statischen Gegenspieler eine erheblich größere lokomotorische Aktivität zeigen (Raz u. Geiger 1982; Volk et al. 1983; Geiger et al. 1985; Zvibel u. Raz 1985; Raz u. Ben-Ze’ev 1987). Ähnliche Ergebnisse wurden auch unter Verwendung des Lewis-Lungenkarzinoms (Young et al. 1985) und eines Rattenmodells des Mammaadenokarzinoms (Badenoch-Jones u. Ramshaw 1984) erzielt, während eine spätere Arbeit am Rattenmodell des Prost at a-adenokarzinoms Dunning R3327 einen weiteren Nachweis für den Zusammenhang zwischen Motilität und metastatischem Potential erbrachte (Moh-ler et al. 1987, 1988; Partin et al. 1989).

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • S. Silletti
  • A. Raz

There are no affiliations available

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