Skip to main content
SpringerLink
Log in

Zellbewegung und Metastasierung: Über die Rolle des Rezeptors des autokrinen Motilitätsfaktors bei Tumorzellen

  • Conference paper
Book cover Immuntherapie in der Uroonkologie

  • 20 Accesses

Zusammenfassung

Die aktive Bewegung durch invadierende Tumorzellen wird als Voraussetzung für die Entstehung von sekundären Neoplasmen angesehen. Der Erfolg einer Metastasierung setzt die Invasion in das umgebende Normalgewebe sowie das Überschreiten der Gefäß- und/oder lymphatischen Grenzen voraus (Nicolson 1988; Fidler 1989). Es wurde vorgeschlagen, daß die Motilität von einzelnen Zellen oder Zellgruppen am Leitsaum einer Tumorprotrusion für eine solche invasive Bewegung verantwortlich sein könnte (Strauli u. Weis 1977). Die Analyse der früher bereits charakterisierten hoch- und niedrig-metastatischen, abgewandelten Subpopulationen zeigte, daß niedrigmeta-statische Zellen weitestgehend unbeweglich sind, während ihre hochmeta-statischen Gegenspieler eine erheblich größere lokomotorische Aktivität zeigen (Raz u. Geiger 1982; Volk et al. 1983; Geiger et al. 1985; Zvibel u. Raz 1985; Raz u. Ben-Ze’ev 1987). Ähnliche Ergebnisse wurden auch unter Verwendung des Lewis-Lungenkarzinoms (Young et al. 1985) und eines Rattenmodells des Mammaadenokarzinoms (Badenoch-Jones u. Ramshaw 1984) erzielt, während eine spätere Arbeit am Rattenmodell des Prost at a-adenokarzinoms Dunning R3327 einen weiteren Nachweis für den Zusammenhang zwischen Motilität und metastatischem Potential erbrachte (Moh-ler et al. 1987, 1988; Partin et al. 1989).

Übersetzung aus dem Engl, von Belinde Junkers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abercrombie M, Heaysman JEM, Pegrum SM (1970) The locomotion of fibroblasts in culture. III. Movement of particles on the dorsal surface of the leading lamella. Exp Cell Res 62: 389–398

    Article  PubMed  CAS  Google Scholar 

  • Albrecht-Buehler G (1977) The phagokinetic tracks of 3T3 cells. Cell 11: 395–404

    Article  PubMed  CAS  Google Scholar 

  • Ashkenazi A, Peralta EG, Winslow JW, Ramachandran J, Capon DJ (1989) Functionally distinct G proteins couple different receptors to PI hydrolysis in the same cell. Cell 56: 487–493

    Article  PubMed  CAS  Google Scholar 

  • Atnip KD, Carter LM, Nicolson GL, Dabbous MK (1987) Chemotactic response of rat mammary adenocarcinoma cell clones to tumor-derived cytokines. Biochem Biophys Res Comm 146: 996–1002

    Article  PubMed  CAS  Google Scholar 

  • Badenoch-Jones P, Ramshaw IA (1984) Spontaneous capillary tube migration of metastatic rat mammary adenocarcinoma cells. Invas Metast 4: 98–110

    CAS  Google Scholar 

  • Bareis DL, Hirata F, Schiffmann E, Axelrod J (1982) Phospholipid merabolism, calcium flux, and the receptor mediated induction of Chemotaxis in rabbit neutrophils. J Cell Biol 93: 690–697

    Article  PubMed  CAS  Google Scholar 

  • Brandt SJ, Dougherty RW, Lapetina EG, Niedel JE (1985) Pertussion toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells. Proc Natl Acad Sci USA 82: 3277–3280

    Article  PubMed  CAS  Google Scholar 

  • Bretscher MS (1983) Distribution of receptors for transferrin and low density lipoprotein on the surface of giant HeLa cells. Proc Natl Acad Sci USA 80: 454–458

    Article  PubMed  CAS  Google Scholar 

  • Bretscher MS (1984) Endocytosis: relation to capping and cell locomotion. Science 226: 681–686

    Article  Google Scholar 

  • Bretscher MS (1989) Endocytosis and recycling of the fibronectin receptor in CHO cells. EMBO J 8: 1341–1348

    PubMed  CAS  Google Scholar 

  • Chopra H, Timar J, Chen YQ et al. (1991) The lipoxegenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integrin aIIbbβ3 on melanoma cells. Int J Cancer 49: 774–786

    Article  PubMed  CAS  Google Scholar 

  • Cooper MS, Cornell-Bell AH, Chernjavsky A, Dani JW, Smith SJ (1990) Tubulovesicular processes emerge from the trans-Golgi cisternae, extend along microtubules, and interlink adjacent trans-Golgi elements into a reticulum. Cell 61: 135–145

    Article  PubMed  CAS  Google Scholar 

  • De Basio RL, Wang LL, Fisher GW, Taylor DL (1988) The dynamic distribution of fluorescent analogues of actin and myosin at the leading edge of migrating Swiss 3T3 fibroblasts. J Cell Biol 107: 2631–2645

    Article  Google Scholar 

  • de Brabander M, Nuydens R, Geerts H, Hopkins CR (1988) Dynamic behavior of the transferrin receptor followed in living epidermoid carcinoma (A431) cells with Nanovid microscopy. Cell Motil Cytoskel 9: 30–47

    Article  Google Scholar 

  • de Brabander M, Nuydens R, Ishahara A, Holifield B, Jacobson K, Geertz H (1991) Lateral diffusion and retrograde movements of individual cell surface components on single motile cells observed with nanovid microscopy. J Cell Biol 112: 111–124

    Article  PubMed  Google Scholar 

  • Eberle M, Traynor-Kaplan AE, Sklar LA, Norgauer J (1990) Is there a relationship between phosphatidylinositol triphosphate and F-actin polymerization in human neutrophils. J Biol Chem 265: 16725–16728

    PubMed  CAS  Google Scholar 

  • Eckstein DJ, Shur BD (1989) Laminin induces the stable expression of surface galactosyl-transferase on lamellipodia of migrating cells. J Cell Biol 108: 2507–2517

    Article  PubMed  CAS  Google Scholar 

  • Evans CP, Walsh DS, Kohn EC (1991) An autocrine motility factor secreted by the Dunning R-3327 rat prostatic adenocarcinoma cell subtype AT2.1. Int J Cancer 49: 109–113

    Article  PubMed  CAS  Google Scholar 

  • Fidler IJ, Gersten DM, Hart IR (1988) The biology of cancer invasion and metastasis. Adv Cancer Res 28: 149–250

    Article  Google Scholar 

  • Garcia-Castro I, Mato JM, Vasanthakumar G, Wiesmann W, Schiffmann E, Chiang PK (1983) Paradoxical effects of adenosine on neutrophil Chemotaxis. J Biol Chem 258: 4345–4349

    PubMed  CAS  Google Scholar 

  • Geiger B, Volk T, Raz A (1985) Cell contacts and cytoskeletal organization of metastatic cell variants. Exp Biol Med 10: 39–53

    Google Scholar 

  • Gherardi E, Gray J, Stoker M, Perryman M, Furlong R (1989) Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Natl Acad Sci USA 86: 5844–5848

    Article  PubMed  CAS  Google Scholar 

  • Gilman AG (1987) G Proteins: Transducers of receptor-generated signals. Ann Rev Biochem 56: 615–649

    Article  PubMed  CAS  Google Scholar 

  • Grey AM, Schor AM, Rushton G, Ellis I, Schor SL (1989) Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts. Proc Natl Acad Sci USA 86: 2438–2442

    Article  PubMed  CAS  Google Scholar 

  • Grossi IM, Fitzgerald LA, Umbarger LA, Nelson KK? Diglio CA, Taylor JD, Honn KV (1989) Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res 49: 1029–1037

    PubMed  CAS  Google Scholar 

  • Guirguis R, Margulies I, Taraboletti G, Schiffmann E, Liotta L (1987) Cytokine-induced pseudopodial protrusion is coupled to tumor cell migration. Nature 329: 261–263

    Article  PubMed  CAS  Google Scholar 

  • Hanks SK, Quinn AM, Hunter T (1988) The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 241: 42–52

    Article  PubMed  CAS  Google Scholar 

  • Herskowitz I, Marsh L (1987) Conservation of a receptor/signal transduction system. Cell 50: 995–996

    Article  PubMed  CAS  Google Scholar 

  • Heuser J (1989) Changes in lysosomes shape and distribution correlated with changes in cytoplasmic pH. J Cell Biol 108: 855–864

    Article  PubMed  CAS  Google Scholar 

  • Hopkins CR, Gibson A, Shipman M, Miller K (1990) Movement of internalized ligand receptor complexes along a continuous endosomal reticulum. Nature 346: 335–339

    Article  PubMed  CAS  Google Scholar 

  • Ishahara A, Holifield B, Jacobson K (1988) Analysis of lateral redistribution of a monoclonal antibody complex plasma membrane glycoprotein which occurs during cell locomotion. J Cell Biol 106: 329–343

    Article  Google Scholar 

  • Kohn EC, Liotta LA, Schiffmann E (1990) Autocrine motility factor stimulates a three-fold increase in inositol trisphosphate in human melanoma cells. Biochem Biophys Res Comm 166: 757–764

    Article  PubMed  CAS  Google Scholar 

  • Kucik DE, Elson EL, Sheetz MP (1990) Cell migration does not produce membrane flow. J Cell Biol 111: 1617–1622

    Article  PubMed  CAS  Google Scholar 

  • Kucik DF, Kuo SC, Elson EL, Sheetz MP (1991) Preferential attachment of membrane glycoproteins t the cytoskeleton at the leading edge of lamella. J Cell Biol 114: 1029–1036

    Article  PubMed  CAS  Google Scholar 

  • Lam WC, Delikatny J, Orr FR, Wass J, Varani J, Wand PA (1981) The chemotactic response of tumor cells. A model for cancer metastasis. Am J Pathol 104: 69–76

    PubMed  CAS  Google Scholar 

  • Liotta LA, Mandler R, Murano G, Katz DA, Gordon RK, Chiang PK, Schiffmann E (1986) Tumor cell autocrine motility factor. Proc Natl Acad Sci USA 83: 3302–3306

    Article  PubMed  CAS  Google Scholar 

  • Marcus PI (1962) Dynamics of surface modification in myxovirus-infected cells. Cold Spring Harbor Symposia on Quantitative Biology, vol XXVII

    Google Scholar 

  • McCarthy JB, Palm SL, Furcht LT (1983) Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin. J Cell Biol 97: 772–777

    Article  PubMed  CAS  Google Scholar 

  • McCarthy JB, Basara ML, Palm SL, Sas F, Furcht TL (1985) The role of cell adhesion proteins laminin and fibronectin in the movement of malignant and metastatic cells. Cancer Met Rev 4: 125–152

    Article  CAS  Google Scholar 

  • McCarthy JB, Hagen ST, Furcht LT (1986) Human fibronectin contains distinct adhesion-and motility-promoting domains for metastatic melanoma cells. J Cell Biol 102: 179–188

    Article  PubMed  CAS  Google Scholar 

  • Mohler JL, Partin AW, Isaacs JT, Coffey DS (1987) Time lapse videomicroscopic identification of Dunning R2237 adenocarcinoma and normal rat prostate cells. J Urol 137: 544–547

    PubMed  CAS  Google Scholar 

  • Mohler JL, Partin AW, Coffey DS (1988) Metastatic potential prediction by a visual grading system of cell motility: Prospective validation in the Dunning R-3327 prostatic adenocarcinoma model. Cancer Res 48: 4312–4317

    PubMed  CAS  Google Scholar 

  • Nabeshima K, Kataska H, Koona M (1986) Enhanced migration of tumor cells in response to collagen degradation products and tumor cell collagenolytic activity. Invas Metas 6: 270–286

    CAS  Google Scholar 

  • Nabi IR, Raz A (1987) Cell shape modulation alters glycosylation of a metastatic melanoma cell surface antigen. Int J Cancer 40: 396–401

    Article  PubMed  CAS  Google Scholar 

  • Nabi IR, Raz A (1988) Loss of metastatic responsiveness to cell shape modulation in a newly characterized B16 melanoma adhesive variant. Cancer Res 48: 1258–1264

    PubMed  CAS  Google Scholar 

  • Nabi IR, Watanabe H, Raz A (1990) Identification of B16-F1 melanoma autocrine motility-like factor receptor. Cancer Res 50: 409–414

    PubMed  CAS  Google Scholar 

  • Nabi IR, Watanabe H, Raz A (1992a) Intracellular translocation of a motility factor receptor to the leading edge of motile fibroblasts. (Submitted)

    Google Scholar 

  • Nabi IR, Le Bivic A, Fambrough DF, Rodriguez-Boulan E (1992b) An endogenous MDCK membrane lysosomal glycoprotein is targeted basolaterally before delivery to lysosomes. J Cell Biol (in press)

    Google Scholar 

  • Nicolson GL (1988) Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at secondary sites. Cancer Met Rev 7: 143–188

    Article  CAS  Google Scholar 

  • Partin AW, Schoeniger JS, Mohler JL, Coffey DS (1989) Fourier analysis of cell motility: Correlation of motility with metastatic potential. Proc Natl Acad Sci USA 86: 1254–1258

    Article  PubMed  CAS  Google Scholar 

  • Poste G (1982) Experimental systems for analysis of the malignant phenotype. Cancer Met Rev 1: 141–199

    Article  CAS  Google Scholar 

  • Raz A, Geiger B (1982) Altered organization of cell-substrate contacts and membrane associated cytoskeleton in tumor cell variants exhibiting different metastatic capabilities. Cancer Res 42: 5183–5190

    PubMed  CAS  Google Scholar 

  • Raz A, Ben-Ze’ev A (1983) Modulation of the metastatic capability in B16 melanoma by cell shape. Science 221: 1307–1310

    Article  PubMed  CAS  Google Scholar 

  • Raz A, Ben-Ze’ev A (1987) Cell-contact and architecture of malignant cells and their relationship to metastasis. Cancer Met Rev 6: 3–21

    Article  CAS  Google Scholar 

  • Raz A, Silletti S, Timar J, Honn KV (1991) Effect of 12-HETE on the expression of autocrine motility factor recceptor and motility in melanoma cells. (Submitted)

    Google Scholar 

  • Cooper MS, Cornell-Bell AH, Chernjavsky A, Dani JW, Smith SJ (1990) Tubulovesicular processes emerge from the trans-Golgi cisternae, extend along microtubules, and interlink adjacent trans-Golgi elements into a reticulum. Cell 61: 135–145

    Article  PubMed  CAS  Google Scholar 

  • De Basio RL, Wang LL, Fisher GW, Taylor DL (1988) The dynamic distribution of fluorescent analogues of actin and myosin at the leading edge of migrating Swiss 3T3 fibroblasts. J Cell Biol 107: 2631–2645

    Article  Google Scholar 

  • de Brabander M, Nuydens R, Geerts H, Hopkins CR (1988) Dynamic behavior of the transferrin receptor followed in living epidermoid carcinoma (A431) cells with Nanovid microscopy. Cell Motil Cytoskel 9: 30–47

    Article  Google Scholar 

  • de Brabander M, Nuydens R, Ishahara A, Holifield B, Jacobson K, Geertz H (1991) Lateral diffusion and retrograde movements of individual cell surface components on single motile cells observed with nanovid microscopy. J Cell Biol 112: 111–124

    Article  PubMed  Google Scholar 

  • Eberle M, Traynor-Kaplan AE, Sklar LA, Norgauer J (1990) Is there a relationship between phosphatidylinositol triphosphate and F-actin polymerization in human neutrophils. J Biol Chem 265: 16725–16728

    PubMed  CAS  Google Scholar 

  • Eckstein DJ, Shur BD (1989) Laminin induces the stable expression of surface galactosyl-transferase on lamellipodia of migrating cells. J Cell Biol 108: 2507–2517

    Article  PubMed  CAS  Google Scholar 

  • Evans CP, Walsh DS, Kohn EC (1991) An autocrine motility factor secreted by the Dunning R-3327 rat prostatic adenocarcinoma cell subtype AT2.1. Int J Cancer 49: 109–113

    Article  PubMed  CAS  Google Scholar 

  • Fidler IJ, Gersten DM, Hart IR (1988) The biology of cancer invasion and metastasis. Adv Cancer Res 28: 149–250

    Article  Google Scholar 

  • Garcia-Castro I, Mato JM, Vasanthakumar G, Wiesmann W, Schiffmann E, Chiang PK (1983) Paradoxical effects of adenosine on neutrophil Chemotaxis. J Biol Chem 258: 4345–4349

    PubMed  CAS  Google Scholar 

  • Geiger B, Volk T, Raz A (1985) Cell contacts and cytoskeletal organization of metastatic cell variants. Exp Biol Med 10: 39–53

    Google Scholar 

  • Gherardi E, Gray J, Stoker M, Perryman M, Furlong R (1989) Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Natl Acad Sci USA 86: 5844–5848

    Article  PubMed  CAS  Google Scholar 

  • Gilman AG (1987) G Proteins: Transducers of receptor-generated signals. Ann Rev Biochem 56: 615–649

    Article  PubMed  CAS  Google Scholar 

  • Grey AM, Schor AM, Rushton G, Ellis I, Schor SL (1989) Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts. Proc Natl Acad Sci USA 86: 2438–2442

    Article  PubMed  CAS  Google Scholar 

  • Grossi IM, Fitzgerald LA, Umbarger LA, Nelson KK? Diglio CA, Taylor JD, Honn KV (1989) Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res 49: 1029–1037

    PubMed  CAS  Google Scholar 

  • Guirguis R, Margulies I, Taraboletti G, Schiffmann E, Liotta L (1987) Cytokine-induced pseudopodial protrusion is coupled to tumor cell migration. Nature 329: 261–263

    Article  PubMed  CAS  Google Scholar 

  • Hanks SK, Quinn AM, Hunter T (1988) The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science 241: 42–52

    Article  PubMed  CAS  Google Scholar 

  • Herskowitz I, Marsh L (1987) Conservation of a receptor/signal transduction system. Cell 50: 995–996

    Article  PubMed  CAS  Google Scholar 

  • Heuser J (1989) Changes in lysosomes shape and distribution correlated with changes in cytoplasmic pH. J Cell Biol 108: 855–864

    Article  PubMed  CAS  Google Scholar 

  • Hopkins CR, Gibson A, Shipman M, Miller K (1990) Movement of internalized ligand receptor complexes along a continuous endosomal reticulum. Nature 346: 335–339

    Article  PubMed  CAS  Google Scholar 

  • Ishahara A, Holifield B, Jacobson K (1988) Analysis of lateral redistribution of a monoclonal antibody complex plasma membrane glycoprotein which occurs during cell locomotion. J CeU Biol 106: 329–343

    Article  Google Scholar 

  • Kohn EC, Liotta LA, Schiffmann E (1990) Autocrine motility factor stimulates a three-fold increase in inositol trisphosphate in human melanoma cells. Biochem Biophys Res Comm 166: 757–764

    Article  PubMed  CAS  Google Scholar 

  • von Heijne G (1986) A new method for predicting signal sequence cleavage sites. Nucl Acid Res 14: 4683–4690

    Article  Google Scholar 

  • Watanabe H, Nabi IR, Raz A (1991a) The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells. Cancer Res 51: 2699–2705

    PubMed  CAS  Google Scholar 

  • Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (1991b) Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J Biol Chem 266: 13442–13448

    PubMed  CAS  Google Scholar 

  • Weidner KM, Behrens J, Vanderkerchove J, Birchmeier W (1990) Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol 111: 2079–2108

    Article  Google Scholar 

  • Weidner KM, Arakaki N, Hartmann G et al. (1991) Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci USA 88: 7001–7005

    Article  PubMed  CAS  Google Scholar 

  • Weinberg RA (1991) Tumor suppressor genes. Science 254: 1138–1146

    Article  PubMed  CAS  Google Scholar 

  • Woodgett JR, Gould KL, Hunter T (1986) Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. Eur J Biochem 161: 177–184

    Article  PubMed  CAS  Google Scholar 

  • Yoshida K, Ozaki T, Ushijina K, Hayashi H (1970) Studies on the mechanisms of invasion in cancer. I. Isolation and purification of a factor chemotactic for cancer cells. Int J Cancer 6: 123–132

    Article  PubMed  CAS  Google Scholar 

  • Young MR, Newby M, Meunier J (1985) Relationships between morphology, dissemination, migration, and prostaglandin E2 secretion by cloned variants of Lewis lung carcinoma. Cancer Res 45: 3918–3923

    PubMed  CAS  Google Scholar 

  • Zvibel I, Raz A (1985) The establishment and characterization of a new Balb/c angiosarcoma tumor system. Int J Cancer 36: 261–272

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. S. Silletti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Raz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Urologische Klinik und Poliklinik, Universitätsklinikum Essen, Hufelandstr. 55, W-4300, Essen 1, Deutschland

    Herbert Rübben  & Mark Goepel  & 

  2. Urologische Universitätsklinik, Moorenstr. 5, W-4000, Düsseldorf 1, Deutschland

    Bernd J. Schmitz-Dräger

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Silletti, S., Raz, A. (1993). Zellbewegung und Metastasierung: Über die Rolle des Rezeptors des autokrinen Motilitätsfaktors bei Tumorzellen. In: Rübben, H., Goepel, M., Schmitz-Dräger, B.J. (eds) Immuntherapie in der Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77830-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77830-8_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77831-5

  • Online ISBN: 978-3-642-77830-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation