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Gastrointestinal Regulatory Peptides pp 199–252Cite as

Peptidergic Regulation of Gastric Acid Secretion

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 106))

Abstract

Hydrochloric acid (HCl) secretion by the gastric parietal cell is controlled by a complex interplay of neural, paracrine and endocrine pathways with peptides in the central nervous system (CNS) and the gastrointestinal (GI) tract playing an important role in all of these processes. The classic approach to defining and characterizing secretory control mechanisms separates events controlling secretion into cephalic, gastric and intestinal phases. Within each phase excitatory and inhibitory pathways are considered. In the intact organism these phases overlap, greatly increasing the complexity of the process. The challenge to investigators past and present has been to devise methods that allow accurate quantitation and characterization of these events. No single experimental model can accomplish these goals and it is only through integration of results obtained from the various in vivo and in vitro models in different species that we can hope to understand all of the mechanisms involved.

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Authors
  1. C. S. Chew
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Editors and Affiliations

  1. Department of Veterinary Biology, Pharmacology Section, University of Minnesota, 1988 Fitch Avenue, Saint Paul, MN, 55108, USA

    David R. Brown Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Chew, C.S. (1993). Peptidergic Regulation of Gastric Acid Secretion. In: Brown, D.R. (eds) Gastrointestinal Regulatory Peptides. Handbook of Experimental Pharmacology, vol 106. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77814-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-77814-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77816-2

  • Online ISBN: 978-3-642-77814-8

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