Peptidergic Regulation of Mucosal Immune Function

  • Feng Chen
  • M. S. O’Dorisio
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 106)


The mucosa of the gastrointestinal (GI) system is the body’s main defense against external antigens such as bacteria, viruses and parasites which enter via oral-fecal routes as well as against antigens in food. The mucosal immune system also defends against abnormal internal antigens such as developing gastrointestinal malignancies. The GI tract is richly supplied with peptidergic neurons, endocrine cells and immune effector cells concentrated in gut-associated lymphoid tissue (GALT); GALT comprises one of the largest immune tissues in the body and accounts for nearly 40% of all immune effector cells. Thus GALT is endowed with the necessary components for a neuroendocrine-immune axis.


Vasoactive Intestinal Peptide Vasoactive Intestinal Polypeptide Opioid Peptide Human Peripheral Blood Mononuclear Cell Immune Effector Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Feng Chen
  • M. S. O’Dorisio

There are no affiliations available

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