Abstract
In our previous study (Hamdorf et al. 1990) we showed that irradiation of the rat caused a number of morphological changes in neurons and glial cells in the developing rat brain.
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References
Angevine JB (1965) Time of origin in the hippocampal region. Exptl Neurol Suppl 2: 1–70.
Bassant MH, Court L (1978) Effects of whole body-gamma-irradiation on the activity of rabbit hippocampal neurons. Radiat Res 75: 593–606.
Borges MM, Paula-Barbosa MM, Volk B (1986) Chronic alcohol consumption induces lipofuscin deposition in the rat hippocampus. Neurobiol Aging 7: 347–355.
Chapman PH, Young RJ (1968) Effect of cobalt 60 gamma irradiation on blood pressure and cerebral blood flow in the Macaca mulatta. Radiat Res 35: 78–85.
Cockerham LG, Cervany TJ, Hampton JD (1986) Postradiational regional cerebral blood flow in primates. Aviat Space Environ Med 57: 578–582.
Crain B, Cotman C, Taylor D, Lynch G (1973) A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat. Brain Res 63: 195–204.
Frotscher M, Hamori J, Wenzel J (1977) Transneural effects of enthorhinal lesions in the early postnatal period of synaptogenesis in the hippocampus of the rat. Exptl Brain Res 30: 549–560.
Gähwiler BH (1984) Slice cultures of cerebellar, hippocampal and hypothalamic tissue. Experientia 40: 236–243.
Gaidamakin NA, Ushakov IB (1989) The state of synapses of the cortex of cerebral hemispheres on gamma-irradiation. Neurosci Behav Physiol 19: 483–488.
Gilmore SA (1963) The effects of X-irradiation on the spinal cords of neonatal rats. II. Histological observations. J Neuropathol Exptl Neurol 22: 294–301.
Gilmore SA (1966) Delayed myelination of neonatal rat spinal cord induced by X-irradiation. Neurology 16: 749–753.
Griffin TW, Rasey JS, Bleyer WA (1977) The effect of photon irradiation on blood brain barrier permeability to methotrexate in mice. Cancer 40: 1109–1111.
Hamdorf G, Shahar A, Cervós-Navarro J, Scheffler A, Sparenberg A, Skoberla A (1990) Morphological changes in cultures of hippocampus following prenatal irradiation in the rat. J Neurosci Res 26: 327–333.
Hamori J (1973) The inductive role of presynaptic axons in the development of postsynaptic spines. Brain Res 62: 337–344.
Hicks SP, D’Amato CJ (1963) Low dose radiation of the developing brain. Science 141: 903–905.
Hornsey S, Myers R, Jenkins T (1990) The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs. Int J Radiat Oncol Biol Phys 18: 1437–1442.
Jaberaboansari A, Nelson GB, Roti JL, Wheeler KT (1988) Postirradiation alterations of neuronal chromatin structure. Radiat Res 114: 94–104.
Jacobs AJ, Maniscalco WM, Parkhurst AB, Finkelstein JN (1986) In vivo and in vitro demonstration of reduced myelin synthesis following early postnatal exposure to ionizing radiation in the rat. Radiat Res 105: 97–104.
Kirino T, Tamura A, Sano K (1985) Selective vulnerability of the hippocampus to ischemia — reversible and irreversible types of ischemic cell damage. Prog Brain Res 63: 39–58.
Kriegel H, Schmahl W, Gerber GB, Stieve FE (eds) (1986) Radiation Risks to the Developing Nervous System. Gustav Fischer, Stuttgart, New York.
McWilliams JR, Lynch G (1984) Synaptic density and axonal sprouting in rat hippocampus: stability in adulthood and decline in late adulthood. Brain Res 294: 152–156.
Miller RW, Mulvihill JJ (1976) Small head size after atomic irradiation. Teratology 14: 335–358.
Mole RH (1986) Problems related to prenatal exposure of the nervous system. History and perspective. In: Kriegel H, Schmahl W, Gerber GB, Stieve FE (eds) Radiation Risks to the Developing Nervous System, Gustav Fischer, Stuttgart, New York.
Nolan CC, Brown AW (1989) Reversible neuronal damage in hippocampal pyramidal cells with triethyllead. The role of astrocytes. Neuropathol Appl Neurobiol 15: 441–457.
Peimer SI, Dudkin HO, Swerdlow AG (1986) Response of hippocampal pacemaker-like neurons to low doses of ionizing radiation. Int J Radiat Biol 49: 597–600.
Peters A, Plalay SL, Webster HF (1991) The fine structure of the nervous system. Neurons and their supporting cells. Oxford University Press, New York.
Raleigh JA, Kremers W, Gabourg B (1977) Dose-rate and oxygen effects in models of lipid membranes: linoleic acid. Int J Radiat Biol 31: 203–213.
Reyners H, Gianfelici-de-Reyners E, Malsin JR (1982) The beta astrocyte: a newly recognized radiosensitive glial cell type in the cerebral cortex. J. Neurocytol 11: 967–983.
Schmidt SL, Lent R (1987) Effects of prenatal irradiation on the development of cerebral cortex and corpus callosum of the mouse. J Comp Neurol 264: 193–204.
Siesjö BK, Rehncrona S, Smith, D (1980) Neuronal cell damage in the brain: possible involvement of oxidative mechanisms. Acta Physiol Scand Suppl 492: 121–128.
Siesjö BK (1981) Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metab 1: 155–185.
Sims TJ, Gilmore SA (1989) Interactions between Schwann cells and CNS axons following a delay in the normal formation of central myelin. Exp Brain Res 75: 513–522.
Sims TJ, Gilmore SA, Waxman SG (1987) Temporary adhesions between axons and myelinforming processes. Develop Brain Res 40: 223–232.
Suzuki R, Yamaguchi T, Li CL, Klatzo I (1983) The effects of 5-minute ischemia in Mongolian gerbils. II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus. Acta Neuropathol (Berlin) 60: 217–222.
Tolliver JM, Pellmar TC (1987) Ionizing radiation alters neuronal excitability in hippocampal slice of the guinea pig. Radiat Res 112: 555–563.
Wanner RA, Edwards MJ (1983) Comparison of the effects of radiation and hyperthermia on prenatal retardation of brain growth of guinea-pigs. Brit J Radiol 56: 33–39.
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© 1992 Springer-Verlag Berlin Heidelberg
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Cervós-Navarro, J., Hamdorf, G., Becker, A., Scheffler, A. (1992). Morphological Changes in Cultures of Hippocampus Following In Vitro Irradiation. In: Neubert, D., Kavlock, R.J., Merker, HJ., Klein, J. (eds) Risk Assessment of Prenatally-Induced Adverse Health Effects. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77753-0_30
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