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Standardisierung und Weiterentwicklung pathologischer Diagnostik bei Weichteilsarkomen

  • D. Harms
  • D. Schmidt
Conference paper

Zusammenfassung

Die Morphologie der Weichteilsarkome ist ein weites, unübersichtliches Feld, voller Fallstricke und Irrwege. Obwohl die meisten Tumortypen gut definiert sind, bereiten deren Diagnostik und Kategorisierung in der Praxis doch häufig mehr Schwierigkeiten, als es Kliniker glauben oder wahrhaben mögen. Von diesen, manchmal desillusionierenden Schwierigkeiten wird zunächst die Rede sein. Im dann folgenden Abschnitt sollen die Fortschritte in der Diagnostik, wie sie insbesondere durch die Immunhistochemie erzielt wurden, dargelegt und kritisch diskutiert werden, und abschließend seien — mit einigem Optimismus gesehen — einige Perspektiven aufgezeigt, wie man die Sarkome und deren biologisches Verhalten in Zukunft noch besser wird verstehen können.

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Literatur

  1. 1.
    Altmannsberger M, Osborn M, Schauer A, Weber K (1981) Antibodies to different intermediate filament proteins. Cell type-specific markers on paraffin-embedded human tissue. Lab Invest 45: 427–434Google Scholar
  2. 2.
    Altmannsberger M, Osborn M, Treuner J, Hölscher A, Weber K, Schauer A (1982) Diagnosis of human childhood rhabdomyosarcoma by antibodies to desmin, the structural protein of muscle specific intermediate filaments. Virchows Arch [B] 39: 203–215CrossRefGoogle Scholar
  3. 3.
    Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M (1991) MIC2 is a specific marker for Ewing’s sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing’s sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67: 1886–1893PubMedCrossRefGoogle Scholar
  4. 4.
    Axiotis C, Hijazi Y, Jefferson J, Tsokos M (1991) Expression of P-glycoprotein in small round cell tumors of childhood. Lab Invest 64: 1 PGoogle Scholar
  5. 5.
    Brooks JJ (1982) Immunohistochemistry of soft tissue tumors: Progress and prospects. Hum Pathol 13: 969–974PubMedCrossRefGoogle Scholar
  6. 6.
    Brooks J J (1986) The significance of double phenotypic patterns and markers in human sarcomas. A new model of mesenchymal differentiation. Amer J Pathol 125: 113–123Google Scholar
  7. 7.
    Brooks JJ (1990) Immunohistochemistry of soft tissue tumors: Uses and pitfalls. International Post-Graduate Course on Soft Tissue Tumors. Riva del Garda. 18.–21. April, 1990. Abstract Volume, pp 45–49Google Scholar
  8. 8.
    Cordell JL, Falini B, Erber WN, Ghosh AK, Zainalabideen A, MacDonald S, Pulford KAF, Stein H, Mason DY (1984) Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase ( APAAP complexes ). J Histochem Cytochem 32: 219–229Google Scholar
  9. 9.
    Dietel M (1991) What’s new in cytostatic drug resistence and pathology? Pathol Res Pract 187: 892–905PubMedGoogle Scholar
  10. 10.
    Enzinger FM, Weiss SW (1983) Soft tissue tumors. Mosby, St. LouisGoogle Scholar
  11. 11.
    Enzinger FM, Weiss SW (1988) Soft tissue tumors, 2nd ed. Mosby, St. LouisGoogle Scholar
  12. 12.
    Enzinger FM, Lattes R, Torloni H (1969) Histological typing of soft tissue tumours. International histological classification of tumours, No. 3. Geneva: World Health OrganizationGoogle Scholar
  13. 13.
    Erlandson RA (1984) Diagnostic immunohistochemistry of human tumors. An interim evaluation. Amer J Surg Pathol 8: 615–624CrossRefGoogle Scholar
  14. 14.
    Harms D, Schmidt D (1986) Spezielle Tumoren des Kindesalters. Verh Dtsch Ges Pathol 70: 190–204PubMedGoogle Scholar
  15. 15.
    Hijazi Y, Tsokos M, Navarro S, Horowitz M, Axiotis C (1991) Immunohistochemical detection of p-glycoprotein in Ewing’s sarcoma and peripheral neuroectodermal tumors (PNET) before and after chemotherapy. Lab Invest 64:5 AGoogle Scholar
  16. 16.
    Katenkamp D, Raikhlin NT (1985) Stem cell concept and heterogeneity of malignant soft tissue tumor — a challange to reconsider diagnostics and therapy? Exp Pathol 28: 3–11PubMedGoogle Scholar
  17. 17.
    Kempson RL, Hendrickson MR (1990) What is a fibrohistiocytic tumour? In: Fletcher CDM, McKee PH (eds) Pathology of soft tissue tumours. Churchill Livingstone. Edinburgh London Melbourne New York, pp 105–140Google Scholar
  18. 18.
    Leuschner I, Schmidt D, Hoffmann H, Dietel M, Harms D (1991) Expression of p-glycoprotein in soft tissue tumors of childhood. Correlation to treatment response. J Cancer Res Clin Oncol 117 (Suppl): 97Google Scholar
  19. 19.
    Limon J, Turc-Carel C, Dal Cin P, Rao U, Sandberg AA (1986) Recurrent chromosome translocations in liposarcoma. Cancer Genet Cytogenet 22: 92–94Google Scholar
  20. 20.
    McKeon C, Thiele CJ, Ross RA, Kwan M, TricheTJ, Miser JS, Israel MA (1988) Indistinguishable pattern of protooncogen expression in two distinct but closely related tumors: Ewing’s sarcoma and neuroepithelioma. Cancer Res 48: 4307–4311Google Scholar
  21. 21.
    Miettinen M, Rapola J (1989) Immunohistochemical spectrum of rhabdomyosarcoma and rhabdomyosarcoma-like tumors. Expression of cytokeratin and the 68-kD neurofilament protein. Am er J Surg Pathol 13: 120–132CrossRefGoogle Scholar
  22. 22.
    Miettinen M, Lehto VP, Badley RA, Virtanen I (1982) Expression of intermediate filaments in soft-tissue sarcomas. Int J Cancer 30: 541–546PubMedCrossRefGoogle Scholar
  23. 23.
    Miettinen M, Lehto VP, Virtanen I (1984) Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors. Ultrastruct Pathol 7: 83–107PubMedCrossRefGoogle Scholar
  24. 24.
    Mukai M, Torikata C, Iri H (1990) Immunohistochemistry of soft-tissue tumours. In: Fletcher CDM, McKee PH (eds) Pathology of soft tissue tumours. Churchill Livingstone. Edinburgh London Melbourne New York, pp 165–184Google Scholar
  25. 25.
    Roholl PJM, De Jong ASH, Ramaekers FCS (1985) Application of markers in the diagnosis of soft tissue tumours. Histopathology 9: 1019–1035PubMedCrossRefGoogle Scholar
  26. 26.
    Sandberg AA, Turc-Carel C (1987) The cytogenetics of solid tumors. Relation to diagnosis, classification and pathology. Cancer 59: 387–395Google Scholar
  27. 27.
    Schmidt D, Harms D (1987) Epithelioid sarcoma in children and adolescents. An immunohistochemical study. Virchows Arch [A] 410: 423–431Google Scholar
  28. 28.
    Schmidt D, Harms D, Burdach S (1985) Malignant peripheral neuroectodermal tumours of childhood and adolescence. Virchows Arch [A] 406: 351–365CrossRefGoogle Scholar
  29. 29.
    Schmidt D, Harms D, Jürgens H (1989 a) Maligne periphere neuroektodermale Tumoren. Histologische und immunhistochemische Befunde an 41 Fällen. Zbl allg Pathol 135: 257–267Google Scholar
  30. 30.
    Schmidt D, Leuschner I, Harms D, Sprenger E, Schäfer HJ ( 1989 b)Malignant rhabdoid tumor. A morphological and flow cytometric study. Pathol Res Pract 184: 202–210Google Scholar
  31. 31.
    Schmidt D, Benn E, Leuschner I, Harms D (1990b) Maligne periphere Nervenscheidentumoren im Kindes- und Adoleszentenalter. Verh Dtsch Ges Pathol 74: 570Google Scholar
  32. 32.
    Schmidt D, Leuschner I, Moeller R, Harms D (1990 a) Immunhistochemische Befunde bei Rhabdomyosarkomen. Pathologe 11: 283–289Google Scholar
  33. 33.
    Schmidt D, Herrmann Ch, Jürgens H, Harms D ( 1991 b) Malignant peripheral neuroectodermal tumor and its necessary distinction from Ewing’s sarcoma. A report from the Kiel Pediatric Tumor Registry. Cancer 68: 2251–2259Google Scholar
  34. 34.
    Schmidt D, Thum P, Harms D, Treuner J (1991a) Synovial sarcoma in children and adolescents. A report from the Kiel Pediatric Tumors Registry. Cancer 67: 1667–1672Google Scholar
  35. 35.
    Scrable H, Witte D, Shimada H, Seemayer T, Wang-Wuu S, Soukup S, Koufos A, Houghton P, Lampkin B, Cavenee W (1989) Molecular differential pathology of rhabdomyosarcoma. Genes, Chromosomes & Cancer 1: 23–35Google Scholar
  36. 36.
    Sternberger LA, Hardy PH, Jr, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18: 315–333Google Scholar
  37. 37.
    Stout AP, Lattes R (1967) Tumors of the soft tissues. Atlas of tumor pathology, 2nd series, fasc 1. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  38. 38.
    Turc-Carel C, Philip I, Berger MP, Philip T, Lenoir GM (1984) Chromosome study of Ewing’s sarcoma (ES) cell lines. Consistency of a reciprocal translocation t (11; 22)(q24; ql2). Cancer Genet Cytogenet 12: 1–19PubMedCrossRefGoogle Scholar
  39. 39.
    Turc-Carel C, Dal Cin P, Limon, J, Li F, Sandberg AA (1986 b) Translocation X; 18 in synovial sarcoma. Cancer Genet Cytogenet 23: 93Google Scholar
  40. 40.
    Turc-Carel C, Lizard-Nacol S, Justrabo E, Favrot M, Philip T, Tabone E (1986 a) Consistent chromosomal translocation in alveolar rhabdomyosarcoma. Cancer Genet Cytogenet 19: 361–362Google Scholar
  41. 41.
    Wang-Wuu S, Soukup S, Ballard E, Gotwals B, Lampkin B (1988) Chromosomal analysis of sixteen human rhabdomyosarcomas. Cancer Res 48: 983–987PubMedGoogle Scholar
  42. 42.
    Whang-Peng J, Triche TJ, Knutsen T, Miser J, Kao-Shan S, Tsai S, Israel MA (1986) Cytogenetic characterization of selected small round cell tumors of childhood. Cancer Genet Cytogenet 21: 185–208PubMedCrossRefGoogle Scholar
  43. 43.
    Woodruff JM (1976) Peripheral nerve tumors showing glandular differentiation (glandular schwannomas). Cancer 37: 2399–2413PubMedCrossRefGoogle Scholar
  44. 44.
    Woodruff JM (1991) Tumors and tumorlike conditions of the peripheral nerve. In: Ninfo V, Chung EB, Cavazzana AO (eds) Tumors and tumorlike lesions of soft tissue. Churchill Livingstome, New York Edinburgh London Melbourne Tokyo, pp 205–228 (Contemporary Issues in Surg Pathol, Vol 18 )Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • D. Harms
  • D. Schmidt

There are no affiliations available

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