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Clinical Neurology in AIDS

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The Central Nervous System in AIDS

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Abstract

In patients with HIV-1 infection, the nervous system is commonly affected (Snider et al. 1983; Levy et al. 1985 a; McArthur 1987; De Gans et al. 1989). Neurological involvement occurs in at least 40% of patients, who usually already meet the CDC clinical criteria for AIDS (Centers for Disease Control 1987), and it is the presenting manifestation in 10% of HIV-infected patients. At autopsy, 80%–90% are found to have neuropathological abnormalities (Anders et al. 1986). Each part of the neuraxis may be involved. Although this spectrum of neurological complications is well known and includes opportunistic infections, neoplasms, and complications caused by or related to HIV-1 itself, newly recognized clinical syndromes or atypical courses of neurological diseases in HIV-1 infected are still being reported. Some of the neurological complications occur in the early and clinically latent phases of the infection, and others are associated with advanced HIV-1 infection.

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  1. Institut für Pathologie, Auguste-Viktoria-Krankenhaus, Rubensstraße 125, 12157, Berlin, Germany

    Juan Artigas , Gernot Grosse  & Fred Niedobitek ,  & 

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Portegies, P. (1993). Clinical Neurology in AIDS. In: Artigas, J., Grosse, G., Niedobitek, F. (eds) The Central Nervous System in AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77732-5_1

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  • DOI: https://doi.org/10.1007/978-3-642-77732-5_1

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