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Transplantation in Experimental Epilepsy

  • Conference paper
Restoration of Brain Function by Tissue Transplantation

Part of the book series: Basic and Clinical Aspects of Neuroscience ((BASIC,volume 5))

Abstract

Epileptic seizures are characterized by hyperexcitability and synchrony among populations of central neurons, but the mechanisms underlying the abnormal patterns of electric activity are only partly known. There is evidence from human autopsy material that the increased excitability results from a loss of inhibitory, presumably GABA-ergic, neurons (GABA, γ-aminobutyric acid). Possibly the hyper-excitability also depends on an abnormal increase of excitatory synaptic mechanisms. Finally, at least in experimental animals, some long-loop neuronal circuitries might be able to influence the development and generalization of epileptiform activity; for example, the noradrenergic locus ceruleus system, which originates in the pons and has widespread projections to almost the entire CNS, dampens seizures in the brain.

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Authors and Affiliations

  1. Restorative Neurology Unit, Department of Neurology, University Hospital, Lund, Sweden

    J. Bengzon & O. Lindvall

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  1. J. Bengzon
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  2. O. Lindvall
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Editors and Affiliations

  1. Restorative Neurology Unit (RNU) Department of Neurology, University Hospital, 221 85, Lund, Sweden

    Olle Lindvall

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© 1993 Springer-Verlag Berlin Heidelberg

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Bengzon, J., Lindvall, O. (1993). Transplantation in Experimental Epilepsy. In: Lindvall, O. (eds) Restoration of Brain Function by Tissue Transplantation. Basic and Clinical Aspects of Neuroscience, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77718-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-77718-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55823-1

  • Online ISBN: 978-3-642-77718-9

  • eBook Packages: Springer Book Archive

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