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Transplantation in Huntington’s Disease: Experimental Basis and Clinical Perspectives

  • A. Björklund
  • K. Wictorin
Part of the Basic and Clinical Aspects of Neuroscience book series (BASIC, volume 5)

Abstract

Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease in the pathogenesis of which a locus on chromosome 4 is thought to play an as yet undetermined role. Atrophy of the striatum, associated with extensive neuronal loss, is the most constant neuropathologic finding, and the extent of striatal atrophy has been correlated with the progression of the disease [21]. Affected patients, in whom the disease usually develops at 35–45 years of age, show a series of symptoms including severe cognitive and emotional disturbances and incapacitating involuntary movements (chorea). The disease generally progresses over 10–20 years, leading directly or indirectly to death (for comprehensive reviews, see [2] and [12]).

Keywords

Globus Pallidus Kainic Acid Ibotenic Acid Striatal Lesion Glutamic Acid Decarboxylase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • A. Björklund
    • 1
  • K. Wictorin
    • 1
  1. 1.Department of Medical Cell Research, Section of NeurobiologyUniversity of LundLundSweden

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