Normal Cell Lineages and the Phenotype of the Breast Cancer Cell

  • Joyce Taylor-Papadimitriou
Part of the ESO Monographs book series (ESO MONOGRAPHS)


The importance of defining the malignant phenotype within the framework of the lineages of the normal cell from which it derives has been clearly demonstrated in the haemopoietic system where the subclassification of leukaemias achieved in this way has led to a more objective approach to disease management and therapy. The success of the approach has depended on 3 major factors, namely, 1) the availability of specific immunological markers (monoclonal antibodies) to define differentiation-related antigens, 2) the easy availability of circulating blood cells and 3) the development of culture systems where primitive and more differentiated progenitor cells could be cultured and induced to clonally differentiate.


Breast Cancer Epidermal Growth Factor Receptor Intermediate Filament Luminal Cell Human Mammary Epithelial Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Joyce Taylor-Papadimitriou
    • 1
  1. 1.Imperial Cancer Research FundLondonUK

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