Abstract
Centrocytic lymphoma is a CD5-positive B cell neoplasm defined in the Kiel classification (Figure 1) [1]. This lymphoma, composed of cells resembling centrocytes (cleaved follicular center cells), is distinguished from other small cleaved cell lymphomas by the lack of transformed cells, the diffuse, vaguely nodular, or mantle zone growth pattern, and immunophenotypic differences (CD5+, CD10-, and strong surface IgM and/or IgD expression) [1, 2]. Transformation to non-cleaved or centroblastic (large cell) lymphomas is rare. Patients are usually males 50&3x2013;70 years of age, who generally present with diffuse lymphadenopathy, splenomegaly, and marrow involvement, and have a median survival > 4 years.
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© 1992 Springer-Verlag Berlin Heidelberg
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Williams, M.E., Swerdlow, S.H., Rosenberg, C.L., Arnold, A. (1992). Centrocytic Lymphoma: a B-Cell Non-Hodgkin’s Lymphoma Characterized by Chromosome 11 BCL-1 and PRAD 1 Rearrangements. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_41
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DOI: https://doi.org/10.1007/978-3-642-77633-5_41
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