Abstract
It is clear now from many studies, that the early B cell repertoire differs significantly from that expressed in the adult. These differences result from not only the variety of V genes that are expressed but also the mechanisms involved in V gene rearrangements [1–5]. Additionally, the phenotypes of early B cells are typical of the B-1 phenotype while the majority of adult cells are of the B-2 type [6]. Previous studies have also established that the ability of B cells to respond to different antigens develops in a hierarchy with a particularly late development of the ability to respond to Polysaccharide antigens [1, 7, 8]. In contrast to the late appearance of B cells capable of responding to specific antigens, the early B cell repertoire is marked by the properties of interconnectivity, autoreactivity and multispecificity which result from the character of the receptors expressed by early B cells.
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© 1992 Springer-Verlag Berlin Heidelberg
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Kearney, J.F. (1992). Early B-Cell Repertoires. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_10
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DOI: https://doi.org/10.1007/978-3-642-77633-5_10
Publisher Name: Springer, Berlin, Heidelberg
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