Therapy of Joint Manifestations

  • P. Herzer


Antibiotic therapy is considered the mainstay of treatment for joint manifestations of Lyme borreliosis. However, many questions remain unanswered, and many difficulties hinder the approach to therapy; for example (a) Large-scale placebo-controlled treatment studies are lacking; (b) uncontrolled or comparative studies do not take spontaneous remissions into account; in the report by Steere et al. (1987) of 21 untreated patients with Lyme arthritis, the number of patients with attacks of arthritis decreased by 10%–20% each year; (c) criteria for judgement of treatment success or failure are defined arbitrarily and heterogenously; and (d) there are uncertainties in the diagnosis of Lyme arthritis and, in particular, as regards arthralgias due to borrelial infection.


Lyme Disease Lyme Borreliosis Lyme Arthritis Intravenous Ceftriaxone Joint Manifestation 
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© Springer-Verlag Berlin Heidelberg 1993

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  • P. Herzer

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