History of Lyme Borreliosis in Europe

  • K. Weber
  • H.-W. Pfister


Knowledge of Lyme borreliosis in Europe has roughly developed in three phases. Between 1883 and 1945, basic descriptions of dermatological and neurological manifestations were presented. The beneficial effect of penicillin and other antibiotics noted in the late 1940s and early 1950s gave a new impetus to the study of the cause and nature of these manifestations, especially the dermatological ones; this phase lasted until 1975. Following the first description of Lyme disease in 1977 and the discovery of the causative organism in the United States in 1982, a third and this time broader look into the disease and much of its surroundings ensued in Europe.


Lyme Disease Borrelia Burgdorferi Lyme Borreliosis Erythema Migrans Tick Bite 
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  1. Ackermann R (1983) Erythema chronicum migrans und durch Zecken übertragene Meningo- polyneuritis (Garin-Bujadoux-Bannwarth): Borrelien-Infektionen? Dtsch Med Wochenschr 108:577–580PubMedGoogle Scholar
  2. Ackermann R, Runne U, Klenk W, Dienst C (1980) Erythema chronicum migrans mit Arthritis. Dtsch Med Wochenschr 105:1779–1781PubMedGoogle Scholar
  3. Ackermann R, Kabatzki J, Boisten HP, Steere AC, Grodzicki RL, Härtung S, Runne U (1984a) Spirochäten-Ätiologie der Erythema-chronicum-migrans-Krankheit. Dtsch Med Wochenschr 109:92–97PubMedGoogle Scholar
  4. Ackermann R, Boisten HP, Kabatzki J, Runne U, Krüger K, Herrmann WP (1984b) Serumantikörper gegen Ixodes-ricinus-SpkochätQ bei Acrodermatitis chronica atrophicans (Herxheimer). Dtsch Med Wochenschr 109:6–10Google Scholar
  5. Ackermann R, Gollmer E, Rehse-Küpper B (1985) Progressive Borrelien-Enzephalomyelitis. Dtsch Med Wochenschr 110:1039–1042PubMedGoogle Scholar
  6. Afzelius A (1910) Verhandlungen der Dermatologischen Gesellschaft zu Stockholm, 28 Oct 1909. Arch Dermatol Syph 101:404Google Scholar
  7. Afzelius A (1921) Erythema chronicum migrans. Acta Derm Venereol (Stockh) 2:120–125Google Scholar
  8. Arnould G, Cuny G, Weber M, Peniu F, André JM, Cagniart MJ (1970) Méningo-polyradiculonévrite à tiques à propos d’une observation. Ann Med Nancy 9:629Google Scholar
  9. Asbrink E (1985) Erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans. Acta Derm Venereol (Stockh) (Suppl) 118:1–63Google Scholar
  10. Asbrink E, Hovmark A (1985) Successful cultivation of spirochetes from skin lesions of patients with erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans. Acta Pathol Microbiol Immunol Scand (B) 93:161–163Google Scholar
  11. Asbrink E, Olsson I (1985) Clinical manifestations of erythema chronicum migrans Afzelius in 161 patients. Acta Derm Venereol (Stockh) 65:43–52Google Scholar
  12. Asbrink E, Hederstedt B, Hovmark A (1984a) The spirochetal etiology of erythema chronicum migrans Afzelius. Acta Derm Venereol (Stockh) 64:291–295Google Scholar
  13. Asbrink E, Hovmark A, Hederstedt B (1984b) The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer. Acta Derm Venereol (Stockh) 64:506–512Google Scholar
  14. Asbrink E, Hovmark A, Olsson I (1986) Clinical manifestations of acrodermatitis chronic atrophicans in 50 Swedish patients. Zentralbl Bakteriol Hyg (A) 263:253–261Google Scholar
  15. Bäfverstedt B (1943) Über Lymphadenosis benigna cutis. Acta Derm Venereol (Stockh) (Suppl) 24:1–202 14Google Scholar
  16. Bäfverstedt B (1960) Lymphadenosis benigna cutis (LABC), its nature, course, and prognosis. Acta Derm Venereol (Stockh) 40:10–18Google Scholar
  17. Balban W (1910) Erythema annulare entstanden durch Insektenstiche. Arch Dermatol Syph 105:423–430Google Scholar
  18. Bammer H, Schenk K (1965) Meningo-Myelo-Radikulitis nach Zeckenbiß mit Erythem. Dtsch Z Nervenheilkd 187:25–34PubMedGoogle Scholar
  19. Bannwarth A (1941) Chronische lymphocytäre Meningitis, entzündliche Polyneuritis und “Rheumatismus”. Arch Psychiatr Nervenkr 113:284–376Google Scholar
  20. Bannwarth A (1944) Zur Klinik und Pathogenese der “chronischen lymphocytären Meningitis”. Arch Psychiatr Nervenkr 117:161–185Google Scholar
  21. Bialasiewicz AA, Ruprecht KW, Naumann GOH, Blenk H (1988) Bilateral diffuse choroiditis and exsudative retinal detachments with evidence of Lyme disease (letter). Am J Ophthalmol 105:419–420PubMedGoogle Scholar
  22. Bianchi GE (1950) Die Penicillinbehandlung der Lymphocytome. Dermatologica 100:270–273PubMedGoogle Scholar
  23. Biberstein H (1923) Lymphozytome. Zentralbl Hautkr 6:70–71Google Scholar
  24. Binder E, Doepfmer R, Hornstein O (1955) Experimentelle Übertragung des Erythema chronicum migrans von Mensch zu Mensch. Hautarzt 6:494–496PubMedGoogle Scholar
  25. Bjornstadt RT, Mossige K (1955) Erythema chronicum migrans med meningopolyradiculitis. Tidsskr Norske Laegerfor 75:264–265Google Scholar
  26. Braun-Falco O, Burg G (1975) Lymphoretikuläre Proliferation in der Haut. Hautarzt 26:124–132Google Scholar
  27. Brehm G (1963) Symptomatische Makro- und Kryoglobulinämie bei Akrodermatitis chronica atrophicans. Hautarzt 14:75–79PubMedGoogle Scholar
  28. Bruder K (1950) Zur Kenntnis des Erythema chronicum migrans (Lipschütz). Dermatol Wochenschr 121:337–344PubMedGoogle Scholar
  29. Brunner N (1951) Zur Penicillinbehandlung bei Sklerodermie und Akrodermatitis atrophicans Herxheimer. Hautarzt 2:545–547Google Scholar
  30. Büchner SA, Rufli T (1987) Erythema chronicum migrans: evidence for cellular immune reaction in the skin lesion. Dermatologica 174:144–149PubMedGoogle Scholar
  31. Buchwald A (1883) Ein Fall von diffuser idiopathischer Haut-Atrophie. Arch Dermatol Syph 10:553–556Google Scholar
  32. Burckhardt JL (1911) Zur Frage der Follikel- und Keimzentrenbildung in der Haut. Frankf Z Pathol 6:352–359Google Scholar
  33. Burg G, Braun-Falco O (1983) Cutaneous lymphomas, pseudolymphomas, and related disorders. Springer, Berlin, Heidelberg, New York, pp 415–441Google Scholar
  34. Burgdorfer W, Barbour AG, Hayes SF, Benach JL, Grunwaldt E, Davis JP (1982) Lyme disease - a tick-borne spirochetosis? Science 216:1317–1319PubMedGoogle Scholar
  35. Christen HJ, Bartlau N, Hanefeld F, Eiffert H, Thomssen R (1990) Peripheral facial palsy in childhood - Lyme borreliosis to be suspected unless proven otherwise. Acta Paediatr Scand 79:1219–1224PubMedGoogle Scholar
  36. Corneau C, Bardet M, Baudoin P, Daumas PL, Oblet B, Poirot G, Valois M (1984) Bloc auri-culo-ventriculaire aigu, syncopal, au cours de la maladie de Lyme. Presse Med 13:888Google Scholar
  37. Dahlsgaard-Nielsen T, Kierkegaard A (1948) Allergic meningitis and chronic erythema migrans Afzelii after bite by Ixodes reduvius. Acta Allerg 1:388–393Google Scholar
  38. Danda J (1963) Die Weltfrequenz der Akrodermatitis chronica atrophicans. Hautarzt 14:337–340PubMedGoogle Scholar
  39. DeKoning J, Hoogkamp-Korstanje JAA (1986) Diagnosis of Lyme disease by demonstration of spirochetes in tissue biopsies. Zentralbl Bakteriol Hyg (A) 263:179–188Google Scholar
  40. DeKoning J, Bosma RB, Hoogkamp-Korstanje JAA (1987) Demonstration of spirochetes in patients with Lyme disease with a modified silver stain. J Med Microbiol 23:261–267Google Scholar
  41. Donnermann C, Heite HJ (1959) Beitrag zur Symptomatologie der Akrodermatitis chronica atrophicans (Pick-Herxheimer). Arch Klin Exp Dermatol 208:516–527PubMedGoogle Scholar
  42. Ehrmann S, Falkenstein F (1925) Über Dermatitis atrophicans und ihre pseudo-sklerodermati- schen Formen. Arch Dermatol Syph 149:142–175Google Scholar
  43. Erbslöh F, Kohlmeyer K (1968) Über polytope Erkrankungen des peripheren Nervensystems bei lymphocytärer Meningitis. Fortschr Neurol Psychiatr 36:321–342Google Scholar
  44. Felgenhauer K (1982) Differentiation of the humoral immune response in inflammatory diseases of the CNS. J Neurol 228:223–227PubMedGoogle Scholar
  45. Finger E, Oppenheim M (1910) Die Hautatrophien. Deuticke, WienGoogle Scholar
  46. Frithz A, Lagerholm B (1983) Acrodermatitis chronica atrophicans, erythema chronicum migrans and lymphadenosis beninga cuis - spirochetal diseases? Acta Derm Venereol (Stockh) 63:432–436Google Scholar
  47. Gans O, Landes E (1952) Akrodermatitis atrophicans arthropatica. Hautarzt 3:151–155Google Scholar
  48. Garin C, Bujadoux (1922) Paralysie par les tiques. J Med Lyon 71:765–767Google Scholar
  49. Gebhart W, Lindemayr W, Partsch H (1971) Ulceromutilierende Neuropathie bei Acrodermatitis chronica atrophicans. Z Hautkr 46:171–178Google Scholar
  50. Gelbjerg-Hansen G (1945) Erythema chronicum migrans Afzelii and meningitis after a tick bite. Acta Derm Venereol (Stockh) 25:458–463Google Scholar
  51. Goor W, Ott F (1971) Zirkulationsstörung - Acrodermatitis chronica atrophicans Pick-Herxheimer? Schweiz Med Wochenschr 101:1334–1348PubMedGoogle Scholar
  52. Götz H (1952) Die Acrodermatitis chronica atrophicans Herxheimer als neue Indikation für die Behandlung mit Chloromycetin. Hautarzt 3:310–312PubMedGoogle Scholar
  53. Götz H (1954/1955) Die Acrodermatitis chronica atrophicans Herxheimer als Infektionskrankheit. Hautarzt 5:491–504, 6:249–252Google Scholar
  54. Götz H, Ludwig E (1951) Die Behandlung der Akrodermatitis chronica atrophicans Herxheimer mit Penicillin. Hautarzt 2:6–14Google Scholar
  55. Gougerot H, Meyer JJ, Flechner K (1951) Acrodermatite de Pick-Herxheimer, au stade de début, traitée par l’auréomycine. Bull Soc Franc Derm Syph 58:386–387PubMedGoogle Scholar
  56. Gsell O (1947) Beiträge zur Meningitis serosa und Radikulitis. Schweiz Arch Neurol Psychiatr 59:135–144PubMedGoogle Scholar
  57. Hardmeier T (1968) Zur Histopathologic der fibroiden Knoten bei Akrodermatitis chronica atrophicans. Arch Klin Exp Dermatol 232:373–383PubMedGoogle Scholar
  58. Hassler D, Zöller L, Haude M, Hufnagel HD, Heinrich F, Sonntag HG (1990) Cefotaxime versus penicillin in the late stage of Lyme disease - prospective, randomized therapeutic study. Infection 18:16–20PubMedGoogle Scholar
  59. Hauser W (1952) Sternalmarkbefunde und ihre Beziehungen zur Blutsenkungsgeschwindigkeit bei Acrodermatitis chronica atrophicans. Arch Dermatol Syph 195:164–170PubMedGoogle Scholar
  60. Hauser W (1955) Zur Kenntnis der Akrodermatitis chronica atrophicans. Arch Dermatol Syph 199:350–393Google Scholar
  61. Hauser W (1965) Wahrscheinliche Infektionskrankheiten der Haut. (Handbuch Haut- u. Geschlechtskrankheiten, vol IV, part 1A), Springer, Berlin Heidelberg New York, pp 556–629Google Scholar
  62. Hellerström S (1930) Erythema chronicum migrans Afzelii. Acta Derm Venereol (Stockh) 11:315–321Google Scholar
  63. Herrmann WP (1961) Immunoelektrophoretische Untersuchungen an Hautkranken. Arch Klin Exp Dermatol 212:452–459PubMedGoogle Scholar
  64. Herxheimer K, Hartmann K (1902) Über Acrodermatitis chronica atrophicans. Arch Dermatol Syph 61:57–76, 255–300Google Scholar
  65. Herxheimer K, Schmidt W (1910) Über “strangförmige Neubildungen bei Acrodermatitis chronica atrophicans”. Arch Dermatol Syph 105:145–168Google Scholar
  66. Herzer P, Wilske B, Preac-Mursic V, Schierz G, Schattenkirchner M, Zöllner N (1986) Lyme arthritits: clinical features, serological and radiographic findings of cases in Germany. Klin Wochenschr 64:206–215PubMedGoogle Scholar
  67. Höfer W (1956) Lymphadenosis benigna cutis. Arch Klin Exp Dermatol 203:23–40PubMedGoogle Scholar
  68. Hollström E (1951) Successful treatment of erythema migrans Afzelius. Acta Derm Venereol (Stockh) 31:235–243Google Scholar
  69. Hollström E (1958) Penicillin treatment of erythema chronicum migrans Afzelius. Acta Derm Venereol (Stockh) 38:285–289Google Scholar
  70. Hopf HC (1966) Acrodermatitis chronica atrophicans (Herxheimer) und Nervensystem. (Monographien aus dem Gesamtgebiete der Neurologie und Psychiatrie, vol 114) Springer, Berlin Heidelberg New YorkGoogle Scholar
  71. Hopf HC, Stroux B (1968) Die geographische Verteilung der Akrodermatitis chronica atrophicans (Herxheimer) in der Umgebung von Würzburg. Z Hautkr 43:41–48Google Scholar
  72. Hörstrup P, Ackermann R (1973) Durch Zecken übertragene Meningopolyneuritis (Garin- Bujadoux, Bannwarth). Fortschr Neurol Psychiatr 41:583–606Google Scholar
  73. Hövelborn C (1931) Gelenkveränderungen bei Acrodermatitis chronica atrophicans. Arch Dermatol Syph 164:349–356Google Scholar
  74. Houwerzyl J, Root JJ, Hoogkamp-Korstanje JAA (1984) A case of Lyme disease with cardiac involvement in the Netherlands (letter). Infection 12:358PubMedGoogle Scholar
  75. Hovind-Hougen K, Asbrink E, Stiernstedt G, Steere AC, Hovmark A (1986) Ultrastructural differences among spirochetes isolated from patients with Lyme disease and related disorders, and from Ixodes ricinus. Zentralbl Bakteriol Hyg (A) 263:103–111Google Scholar
  76. Hovmark A, Asbrink E, Olsson I (1986a) The spirochetal etiology of lymphadenosis benigna cutis solitaria. Acta Derm Venereol (Stockh) 66:479–484Google Scholar
  77. Hovmark A, Asbrink E, Olsson I (1986b) Joint and bone involvement in Swedish patients with Ixodes ricinus borne Borrelia infection. Zentralbl Bakteriol Hyg (A) 263:275–284Google Scholar
  78. Huber A (1900) Über Atrophica cutis idiopathia im Gegensatz zur senilen Atrophie der Haut. Arch Dermatol Syph 52:71–90Google Scholar
  79. Huismann G (1944) Über chronische lymphocytäre Meningitis mit Facialisbeteiligung. Arch Psychiatr Nervenkr 117:443–448Google Scholar
  80. Jessner M (1921) Zur Kenntnis der Acrodermatitis chronica atrophicans. Arch Dermatol Syph 134:478–487Google Scholar
  81. Jessner M, Loewenstamm A (1924) Bericht über 66 Fälle von Acrodermatitis chronica atrophicans. Dermatol Wochenschr 79:1169–1177Google Scholar
  82. Kaiser M (1972) Neurologische Komplikationen bei Akrodermatitis chronica atrophicans (Herxheimer) und ihre Beeinflussung durch die PenicÜlintherapie. Dissertation, University of GöttingenGoogle Scholar
  83. Kerl W (1915) Erythema chronicum migrans. Arch Dermatol Syph 119:301Google Scholar
  84. Ketron LW (1913) Dermatitis atrophicans: with reports of a case showing a fibroid formation. Urol Cutan Ree Techn (Suppl) 1:286–294Google Scholar
  85. Keuth U, Mennicken U (1966) Zur Kenntnis der “peripheren” Facialisparese mit subakut-chronisch lymphozytärer Meningitis (Bannwarth). Z Kinderheilkd 97:45–56Google Scholar
  86. Klenk W, Heitmann R, Ackermann R (1985) Rezidivierende Erythema-chronicum-migrans- Krankheit des Nervensystems: Querschnittmyelitis als Rückfall einer Meningopolyneuritis Garin-Bujadoux-Bannwarth. Aktuel Neurol 12:20–23Google Scholar
  87. Kohlhepp W, Mertens HG (1984/1985) Chronische Meningomyeloradikulitis durch Ixodes-rici- wi/s-Spirochäten - eine der Metalues analoge Spirochätose? Springer, Berlin Heidelberg New York, pp 747–749 (Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 3)Google Scholar
  88. Kohlhepp W, Kuhn W, Krüger H (1989) Extrapyramidal features in central Lyme borreliosis. Eur Neurol 29:150–155PubMedGoogle Scholar
  89. Kraus Z, Mateja F, Mazak J (1963) Myelogram and cryoglobulins in acrodermatitis chronica atrophicans. Acta Derm Venereol (Stockh) 43:163–175Google Scholar
  90. Kristoferitsch W, Spiel G, Wessely P (1983) Zur Meningopolyneuritis (Garin-Bujadoux, Bannwarth). Nervenarzt 54:640–646PubMedGoogle Scholar
  91. Kristoferitsch W, Sluga E, Graf M, Partsch H, Neumann R, Stanek G, Budka H (1988) Neuropathy associated with acrodermatitis chronica atrophicans. Ann NY Acad Sci 539:35–45PubMedGoogle Scholar
  92. Krüger H, Englert D, Pflughaupt KW (1981) Demonstration of oligoclonal immunoglobulin G in Guillan-Barre syndrome and lymphocytic meningoradiculitis by isoelectric focusing. J Neurol 226:15–24PubMedGoogle Scholar
  93. Lipschütz B (1913) Über eine seltene Erythemform (Erythema chronicum migrans). Arch Dermatol Syph 118:349–356Google Scholar
  94. Lipschütz B (1923) Weiterer Beitrag zur Kenntnis des “Erythema chronicum migrans”. Arch Dermatol Syph 143:365–374Google Scholar
  95. Löwenfeld W (1932) Acrodermatitis und Dermatochalasis. Zentralbl Hautkr 41:562Google Scholar
  96. Ludwig E (1955) Über die Wirksamkeit der Antibiotica Streptomycin und Tetracyclin bei der Behandlung der Acrodermatitis atrophicans Herxheimer. Arch Klin Exp Dermatol 201:495–506PubMedGoogle Scholar
  97. Mach KW, Wilgram GF (1966) Characteristic histopathology of cutaneous lymphoplasia (lym-phocytoma). Arch Dermatol 94:26–32PubMedGoogle Scholar
  98. May EF, Jabbari B (1990) Stroke in neuroborreliosis. Stroke 21:1232–1235PubMedGoogle Scholar
  99. Meyer-Rienecker HJ, Hietzschke B (1978) Lymphocytic meningoradiculitis. Elsevier, Amsterdam, pp 571–586 (Handbook of clin neurology, vol 34)Google Scholar
  100. Montgomery H, Sullivan RR (1945) Acrodermatitis atrophicans chronica. Arch Dermatol 51:32–47Google Scholar
  101. Müller H (1969) Akrodermatitis atrophicans arthropathica mit Pseudosklerodermie, Sklero-dermia circumscripta und muskulärer Beteiligung. Z Hautkr 44:1–12Google Scholar
  102. Mulzer P, Keining E (1929) Über miliare Lymphozytome der Haut. Dermatol Wochenschr 88:293–301Google Scholar
  103. Neubert U (1984) Zur Ätiologie von Erytherma-migrans-Krankheit und Lyme-Erkrankung. Hautarzt 35:563–570PubMedGoogle Scholar
  104. Neubert U, Krampitz HE (1984) Spirochaetal antibodies in patients with erythema chronicum migrans, meningoradiculitis Bannwarth and acrodermatitis chronica atrophicans (abstract). J Invest Dermatol 82:544–545Google Scholar
  105. Neubert U, Krampitz HE, Engl H (1986) Microbiological findings in erythema chronicum migrans, acrodermatitis chronica atrophicans und lymphadenosis cutis benigna. Zentralbl Bakteriol Hyg (A) 263:237–252Google Scholar
  106. Olsson J, Engervall K, Asbrink E, Carlsson-Nordlander B, Hovmark A (1988) Tick-borne borreliosis and facial palsy. Acta Otolaryngol (Stockh) 105:100–107Google Scholar
  107. Paschoud JM (1954) Lymphocytom nach Zeckenbiss. Dermatologica 108:435–437PubMedGoogle Scholar
  108. Paschoud JM (1957/1958) Die Lymphadenosis benigna cutis als übertragbare Infektionskrankheit. Hautarzt 8:197–211, 9:153–165, 263–269, 311–315Google Scholar
  109. Pellizari C (1884) Atrophierendes Erythema urticatum. Arch Dermatol Syph 16:504–506Google Scholar
  110. Pfister HW, Einhäupl KM, Preac-Mursic V, Wilske B, Schierz G (1984) The spirochetal etiology of lymphocytic meningoradiculitis of Bannwarth (Bannwarth’s syndrome). J Neurol 231:141–144PubMedGoogle Scholar
  111. Pfister HW, Einhäupl KM, Wilske B, Preac-Mursic V (1986a) Bannwarth’s syndrome and the enlarged neurological spectrum of arthropod-borne borreliosis. Zentralbl Bakteriol Hyg (A) 263.343–347Google Scholar
  112. Pfister HW, Neubert U, Wilske B, Preac-Mursic V, Einhäupl KM, Borasio GD (1986b) Reinfection withBorrelia burgdorferi (letter). Lancet 11:984–985Google Scholar
  113. Pfister HW, Preac-Mursic V, Wilske B, Einhäupl KM (1989) Cefotaxime vs penicillin G für acute neurologic manifestations in Lyme borreliosis. Arch Neurol 46:1190–1194PubMedGoogle Scholar
  114. Pfister HW, Preac-Mursic V, Wilske B, Einhäupl KM, Schielke E, Sörgel F (1991) Randomized comparison of ceftriaxone and cefotaxime in Lyme borreliosis. J Infect Dis 163:311–318PubMedGoogle Scholar
  115. Piorkowski (1926) Zwei Fälle von Acrodermatitis chronica atrophicans. Zentralbl Haut 19:362Google Scholar
  116. Pirilä V (1951) The penicillin treatment of acrodermatitis atrophicans chronica. Acta Derm Venereol (Stockh) 31:576–591Google Scholar
  117. Pospelow A (1886) Cas d’une atrophie idiopathique de la peau. Annales de Dermatol 7:505–510Google Scholar
  118. Postic D, Edlinger, C, Richard C et al. (1990) Two genomic species in Borrelia burgdorferi. Res Microbiol 141:465–475PubMedGoogle Scholar
  119. Preac-Mursic V, Schierz G, Pfister HW, Einhäupl KM, Wilske B, Weber K (1984a) Isolierung einer Spirochäte aus Liquor cerebrospinalis. Münch Med Wochenschr 126:275–276Google Scholar
  120. Preac-Mursic V, Wilske B, Schierz G, Pfister HW, Einhäupl KM (1984b) Repeated isolation of spirochetes from the cerebrospinal fluid of a patient with meningoradiculitis Bannwarth. Eur J Clin Microbiol 3:564–565PubMedGoogle Scholar
  121. Preac-Mursic V, Wilske B, Herzer P, Schierz G, Bauer M (1985) Acrodermatitis chronic atrophicans - eine Borreliose! Hautarzt 36:691–693PubMedGoogle Scholar
  122. Preac-Mursic V, Wilske B, Schierz G (1986) European Borrelia burgdorferi isolated from humans and ticks: culture conditions and antibiotic susceptibility. Zentralbl Bakteriol Hyg (A) 263:112–118Google Scholar
  123. Preac-Mursic V, Wilske B, Schierz G, Holmburger M, Süss E (1987) In vitro and in vivo susceptibility of Borrelia burgdorferi. Eur J Clin Microbiol 6:424–426Google Scholar
  124. Putkonen T, Mustakallio KK, Salminen A (1962) Erythema chronicum migrans with meningitis: a rare coincidence of two tick-borne diseases? Dermatologica 125:184–188PubMedGoogle Scholar
  125. Rehse-Küpper B, Ackermann R (1986) Demonstration of locally sythesized Borrelia antibodies in cerebrospinal fluid. Zentralbl Bakteriol Hyg (A) 263:407–411Google Scholar
  126. Rancurel G (1969) Polyradiculonevrites ä tiques. Concours Med 91:8876Google Scholar
  127. Riehl G (1913) Arch Dermatol Syph 115:401Google Scholar
  128. Rohmer F, Collard M, Jesel M, Warter JM, Coquillat G, Class JJ (1974) Les meningoradiculites: donnees cliniques, electromyographiques et etiologiques a propos de 36 observations. Limites nosologiques. Rev Neurol 130:415–431PubMedGoogle Scholar
  129. Rusch P (1906) Über idiopathische Hautatrophie und Skerlodermie. Dermatol Z 13:749–774Google Scholar
  130. Ryberg B, Nilsson B, Burgdorfer W, Barbour AG (1983) Antibodies to Lyme-diesease spiro- chaete in European lymphocytic meningoradiculitis (Bannwarth’s syndrome) (letter). Lancet 11:519Google Scholar
  131. Sälde H (1946) cited in Hellerström S (1951) Erythema chronicum migrans Afzelius with meningitis. Acta Derm Venereol (Stockh) 31:227–234Google Scholar
  132. Sandbank M, Feuermann EJ (1972) Ultrastructural observation of Rickettsia-like bodies in erythema chronicum migrans. J Cutan Pathol 6:253–264Google Scholar
  133. Schaible UE, Kramer MD, Musteanu C, Zimmer G, Mossmann H, Simon MM (1989) The severe combined immunodeficiency (seid) mouse: a laboratory model for the analysis of Lyme arthritis and carditis. J Exp Med 170:1427–1432PubMedGoogle Scholar
  134. Schaltenbrand G (1949) Chronische aseptische Meningitis. Nervenarzt 20:433–442Google Scholar
  135. Schaltenbrand G (1962) Radikulomyelomeningitis nach Zeckenbiß. Münch Med Wochenschr 104:829–834PubMedGoogle Scholar
  136. Schaltenbrand G (1967) Durch Artropoden übertragene Erkrankung der Haut und des Nervensystems. Verhandl Dtsch Ges Inn Med 72:975–1006Google Scholar
  137. Schirduan M (1950) Verdacht auf Toxoplasmose bei Meningitis nach Erythema chronicum migrans bullosum. Arch Dermatol Syph 192:256–260Google Scholar
  138. Schmoeckel C, Burg G, Wolff HH, Braun-Falco O (1977) The ultrastructure of lymphadenosis benigna cutis (pseudolymphoma cutis). Arch Dermatol Res 258:161–167PubMedGoogle Scholar
  139. Schmutzhard E, Willeit J, Gerstenbrand F (1986) Meningopolyneuritis Bannwarth with focal nodular myositis. Klin Wochenschr 64:1204–1208PubMedGoogle Scholar
  140. Sedlacek V (1960) Erythema chronicum migrans - poznamky ke klinice, etiopatogenezi a zara-zeni. Cs Dermatol 35:386–399Google Scholar
  141. Sköldenberg B, Stiernstedt G, Garde A, Kolmodin G, Carlström A, Nord CE (1983) Chronic meningitis caused by a penicillin-sensitive microorganism? Lancet 11:75–78Google Scholar
  142. Sonck CE (1965) Erythema chronicum migrans with multiple lesions. Acta Derm Venereol (Stockh) 45:34–36Google Scholar
  143. Stadelmann R (1934) Ein Beitrag zum Krankheitsbild des Erythema chronicum migrans Lipschütz. Dissertation, University of MarburgGoogle Scholar
  144. Stanek G, Wewalka G, Groh V, Neumann R (1985a) Isolation of spirochetes from the skin of patients with erythema chronicum migrans in Austria. Zentralbl Bakteriol Hyg (A) 260:88–90Google Scholar
  145. Stanek G, Wewalka G, Groh V, Neumann R, Kristoferitsch W (1985b) Differences between Lyme disease and European arthropod-borne borrelia infections (letter). Lancet 1:401PubMedGoogle Scholar
  146. Steere AC (1989) Lyme disease. N Engl J Med 321:586–596PubMedGoogle Scholar
  147. Steere AC, Malawista SE, Hardin JA, Ruddy S, Askenase PW, Andiman WA (1977) Erythema chronicum migrans and Lyme arthritis: the enlarging clinical spectrum. Ann Intern Med 86:685–698PubMedGoogle Scholar
  148. Steere AC, Bartenhagen NH, Craft JE et al. (1986) Clinical manifestations of Lyme disease. Zentralbl Bakteriol Hyg (A) 263:201–205Google Scholar
  149. Stiernstedt GT, Sköldenberg B, Vandvik B, Hederstedt B, Garde A, Kolmodin G, Jörbeck H, Svenungsson B (1984) Chronic meningitis and Lyme disease in Sweden. Yale J Biol Med 57:491–497PubMedGoogle Scholar
  150. Stiernstedt G, Sköldenberg B, Garde A, Kolmodin G, Jörbeck, H, Svenungsson B, Carlström A (1986) Clinical manifestations of Borrelia infections of the nervous system. Zentralbl Bakteriol Hyg (A) 263:289–296Google Scholar
  151. Strandberg J (1920) Regarding an unusual form of migratory erythema caused by tick bites. Acta Derm Venereol (Stockh) 1:422–427Google Scholar
  152. Svartz N (1946) Penicillinbehandling vid dermatitis atrophicans Herxheimer. Nord Med 32:2783Google Scholar
  153. Sweitzer SE, Laymon CW (1935) Acrodermatitis chronica atrophicans. Arch Dermatol Syph 31:196–211Google Scholar
  154. Thöne AW (1968) Ixodes ricinus und erythema chronicum migrans (Afzelius). Dermatologica 136:57–60Google Scholar
  155. Thyresson N (1949) The penicillin treatment of acrodermatitis chronica atrophicans (Herxheimer). Acta Derm Venereol (Stockh) 29:572–621Google Scholar
  156. Tjernlund U, Scheynius A, Asbrink E, Hovmark A (1986) Expression of HLA-DQ antigens on keratinocytes in Borrelia spirochete-induced skin lesions. Scand J Immunol 23:383–388PubMedGoogle Scholar
  157. Touton K (1886) Fall von erworbener idiopathischer Hautatrophie. Dtsch Med Wochenschr 12:6Google Scholar
  158. Vallat JM, Leboutet MJ, Loubet A, Dumas P, Hugon J, Corvisier N (1984) Tick bite neuropathy: an analysis of nerve biopsies from seven cases. Neurology 34 (Suppl 1): 180–181Google Scholar
  159. Weber K (1974) Erythema-chronicum-migrans-Meningitis - eine bakterielle Infektionskrankheit? Munch Med Wochenschr 116:1993–1998Google Scholar
  160. Weber K (1981) Treatment of Lyme disease. Ann Intern Med 94:137 (letter)Google Scholar
  161. Weber K (1984) Jarisch-Herxheimer-Reaktion bei Erythema-migrans-Krankheit. Hautarzt 35: 588–590PubMedGoogle Scholar
  162. Weber K, Braun-Falco O (1974) Blutbildveränderungen bei Erythema chronicum migrans. Hautarzt 25:611–613PubMedGoogle Scholar
  163. Weber K, Neubert U (1986) Clinical features of early erythema migrans disease and related disorders. Zentralbl Bakteriol Hyg (A) 263:209–228Google Scholar
  164. Weber K, Puzik A, Becker T (1983) Erythema-migrans-Krankheit: Beitrag zur Klinik und Beziehung zur Lyme-Krankheit. Dtsch Med Wochenschr 108:1182–1190PubMedGoogle Scholar
  165. Weber K, Schierz G, Wilske B, Preac-Mursic V, Burgdorfer W, Barbour AG (1983/1984) Antibodies against Ixodes dammini and Ixodes ricinus spirochetes in tick-borne disorders. 11 th ADF meeting, Kiel, 12 Nov 1983 (abstract). Arch Dermatol Res 276:260Google Scholar
  166. Weber K, Schierz G, Wilske B, Preac-Mursic V (1984a) European erythema migrans disease and related disorders. Yale J Biol Med 57:463–471PubMedGoogle Scholar
  167. Weber K, Schierz G, Wilske B, Preac-Mursic V (1984b) Zur Klinik und Ätiologie der Acrodermatitis chronica atrophicans. Hautarzt 35:571–577PubMedGoogle Scholar
  168. Weber K, Schierz G, Wilske B, Preac-Mursic V (1985) Das Lymphozytom - eine Borreliose? Z Hautkr 60:1585–1598PubMedGoogle Scholar
  169. Weber K, Neubert U, Thurmayr R (1986a) Antibiotic therapy in early erythema migrans disease and related disorders. Zentralbl Bakteriol Hyg (A) 263:377–388Google Scholar
  170. Weber K, Schierz G, Wilske B, Neubert U, Krampitz HE, Barbour AG, Burgdorfer W (1986b) Reinfection in erythema migrans disease. Infection 14:32–35; see also Zentralbl Hautkr (1985) 150:628–629PubMedGoogle Scholar
  171. Weber K, Preac-Mursic V, Neubert U et al. (1988a) Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. Ann NY Acad Sci 539:324–345PubMedGoogle Scholar
  172. Weber K, Bratzke HJ, Neubert U, Wilske B, Duray PH (1988b) Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. Pediatr Infect Dis 7:286–289Google Scholar
  173. Weber K, Preac-Mursic V, Wilske B, Thurmayr R, Neubert U, Scherwitz C (1990) A randomized trial of ceftriaxone versus oral penicillin for the treatment of early European Lyme borreliosis. Infection 18:91–96PubMedGoogle Scholar
  174. Wenig C (1975) Chronische lymphocytäre Meningitis mit polytoper Beteiligung des Nervensystems (nach Zeckenbiß?). Psychiatr. Neurol Med Psychol 27:592–600Google Scholar
  175. Wilske B, Schierz G, Preac-Mursic V, Weber K, Pfister HW, Einhäupl KM (1984) Serological diagnosis of erythema migrans disease and related disorders. Infection 12:331–337PubMedGoogle Scholar
  176. Wilske B, Preac-Mursic V, Schierz G (1985a) Antigenic heterogeneity of European Borrelia burgdorferi strains isolated from patients and ticks (letter). Lancet 1:1099PubMedGoogle Scholar
  177. Wilske B, Münchhoff P, Schierz G, Preac-Mursic V, Roggendorf M, Zoulek G (1985b) Zur Epidemiologie der Borrelia burgdorferi Infektion bei Waldarbeitern aus Oberbayern. Munch Med Wochenschr 127:171–172Google Scholar
  178. Wilske B, Preac-Mursic V, Schierz G, von Busch K (1986a) Immunochemical and immunological analysis of European Borrelia burgdorferi strains. Zentralbl Bakteriol Hyg (A) 263:92–102Google Scholar
  179. Wilske B, Schierz G, Preac-Mursic V, von Busch K, Kühbeck R, Pfister HW, Einhäupl K (1986b) Intrathecal production of specific anbibodies against Borrelia burgdorferi in patients with lymphocytic meningoradiculitis (Bannwarth’s syndrome). J Infect Dis 153:304–314PubMedGoogle Scholar
  180. Wilske B, Preac-Mursic V, Schierz G, Gueye W, Herzer P, Weber K (1988a) Immunochemische Analyse der Immunantwort bei Spätmanifestationen der Lyme Borreliose. Zentralbl Bakteriol Hyg (A) 267:549–558Google Scholar
  181. Wilske B, Preac-Mursic V, Schierz G, Kühbeck R, Barbour AG, Kramer M (1988b) Antigenic variability of Borrelia burgdorferi. Ann NY Acad Sci 539:126–143PubMedGoogle Scholar
  182. Wolf G (1970) Über die chronische lymphozytäre Meningitis unter dem Bilde der Polyneuritis (Bannwarth). Fortschr Neurol Psychiatr 38:221–234Google Scholar
  183. Zellweger H (1946) Über die chronische allergische Meningitis. Helv Paediatr Acta 1:417–426PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • K. Weber
  • H.-W. Pfister

There are no affiliations available

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