Abstract
Infectious retinitis and proliferative vitreo-retinopathy (PVR) are two disorders in which there is a need for antiviral and antiproliferative drugs to be delivered to the retina giving therapeutic levels over intervals of weeks to months. Currently, intravitreal ganciclovir is given to AIDS patients with cytomegalvirus rentinitis who are intolerant or unwilling to take ganciclovir intravenously. Antimetabolites capable of inhibiting PVR would be an important therapeutic modality; treatment trails with intraocular irrigation of daunorubicin are currently underway. We have explored the intraocular toxicity of polar anti-CMV drugs and anti-proliferative agents which we have previously shown can be incorporated into a multivesicular liposome system. We have shown that these drugs are not toxic at concentrations many times above those necessary for therapeutic effect when injected intravitreally. We will review electrophysiologic and morphologic data on the toxicity of both the drugs and their liposome preparations injected intravitreally. Our laboratory studies suggest that certain polar antiviral and antimetabolite drugs can be delivered at efficacious concentrations without evidence of toxicity in animal models.
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© 1992 Springer-Verlag Berlin Heidelberg
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Freeman, W.R. et al. (1992). Experimental Intravitreal Drug Delivery for Retinal Disease. In: Gramer, E., Kampik, A. (eds) Pharmakotherapie am Auge. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77532-1_20
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DOI: https://doi.org/10.1007/978-3-642-77532-1_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55496-7
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