Abstract
Results from the past decade of molecular genetics and cell biology research have confirmed the assumption that the loss of control over proliferation and differentiation of cells in fact is a multistep cascade of events. The models of tumorigenesis established by several investigators during the late 1960s and early 1970s have been experimentally verified in the meantime and are now, with a few modifications, widely accepted as the “Knudson model”.
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© 1993 Springer-Verlag Berlin Heidelberg
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Zang, K.D. (1993). Gene Loss as Marker in Tumor Development: Considerations of the Origin of Specific Brain Tumors Due to Combinant Loss of Function Mutations of Tumor Suppressor Genes. In: Wagener, C., Neumann, S. (eds) Molecular Diagnostics of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77521-5_2
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DOI: https://doi.org/10.1007/978-3-642-77521-5_2
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