Advertisement

Marrow Transplantation from Unrelated Donors

  • P. G. Beatty

Abstract

As bone marrow transplantation has evolved into the treatment of choice for many hematologic malignancies (Storb et al. 1984; Goldman et al. 1986; Thomas 1983), the lack of HLA-identical sibling donors for most patients has become a major issue. Given the current average family size in the USA of approximately 2.7 children, only 35% of patients can anticipate having an HLA-identical sibling (Nesbit et al. 1987; Appelbaum et al. 1986). For this reason, many centers have begun exploring the use of HLA-matched or HLA-similar unrelated volunteer donors.

Keywords

Major Histocompatibility Complex Bone Marrow Transplantation Aplastic Anemia Graft Versus Host Disease Unrelated Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anasetti C, Amos D, Beatty PG, et al. (1989) Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med 320:197PubMedCrossRefGoogle Scholar
  2. Appelbaum FR, Hewlett J, Kopecky K, et al (1986) Prospective cooperative study of bone marrow transplantation versus continued chemotherapy for adult nonlymphocytic leukemia: a Southwest Oncology Group Study (Abstr). Blood 68:216aGoogle Scholar
  3. Ash RC, Casper JT, Chitambar CR, et al (1990) Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. N Engl J Med 322:485–494PubMedCrossRefGoogle Scholar
  4. Beatty PG, Clift RA, Mickelson EM, et al (1985) Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med 313:765PubMedCrossRefGoogle Scholar
  5. Beatty PG, Dahlberg S, Mickelson EM, et al (1988) Probability of finding HLA-matched unrelated marrow donors. Transplantation 45:714PubMedCrossRefGoogle Scholar
  6. Beatty PG, Layrisse Z, van Seventer GA, et al (1989 a) T-cell recognition of HLA Class I determinants. In: Dupont B (ed) Immunogenetics and histocompatibility. Springer, Berlin Heidelberg New York, pp 359–362 (Immunobiology of HLA, vol 2)Google Scholar
  7. Beatty PG, Atcher C, Hess E, et al (1989b) Recruiting blood donors into a local bone marrow donor registry. Transfusion 29:778PubMedCrossRefGoogle Scholar
  8. Beatty PG, Hansen JA, Longton GM, et al (1991) Marrow transplantation from HLA-matched unrelated donors for treatment of hematologic malignancies. Transplantation 51:443PubMedCrossRefGoogle Scholar
  9. Choo SY, Antonelli P, Nisperos B, et al (1986) Six variants of HLA-B27 identified by isoelectric focusing. Immunogenetics 23:24PubMedCrossRefGoogle Scholar
  10. Dill O, Kievits F, Koch S, et al (1988) Immunologic function of HLA-C antigens in HLA-Cw3 transgenic mice. Proc Natl Acad Sci USA 85:5664PubMedCrossRefGoogle Scholar
  11. Duquesnoy RJ, Zeevi A, Marrari M, et al (1983) Bone marrow transplantation for severe aplastic anemia using a phenotypically HLA-identical SB-compatible unrelated donor. Transplantation 35:566–571PubMedCrossRefGoogle Scholar
  12. Fleischhauer K, Kernan NA, O’Reilly RJ, et al (1990) Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44. N Engl J Med 323:1818–1822PubMedCrossRefGoogle Scholar
  13. Foroozonfar N, Hobbs JR, Hugh-Jones K, et al (1977) Bone marrow transplant from an unrelated donor for chronic granulomatous disease. Lancet 1:210–213Google Scholar
  14. Gingrich RD, Howe CWS, Goeken NE, et al (1985) The use of partially matched, unrelated donors in clinical bone marrow transplantation. Transplantation 39:526PubMedCrossRefGoogle Scholar
  15. Gingrich RD, Ginder GD, Goeken NE, et al (1988) Allogeneic marrow grafting with partially mismatched, unrelated marrow donors. Blood 71:1375–1381PubMedGoogle Scholar
  16. Goldman JM, Apperley J, Jones L, et al (1986) Bone marrow transplantation for patients with chronic myeloid leukemia. N Engl J Med 314:202PubMedCrossRefGoogle Scholar
  17. Gordon-Smith EC, Fairhead SM, Chipping SM, et al (1982) Bone-marrow transplantation for severe aplastic anemia using histocompatible unrelated volunteer donors. Br Med J 285:835–837CrossRefGoogle Scholar
  18. Goulmy E (1988) Minor histocompatibility antigens in man and their role in transplantation. In: Morris PJ, Tilney NL (eds) Transplant reviews. Saunders, Philadelphia, p 29Google Scholar
  19. Hansen JA, Clift RA, Thomas ED, et al (1980) Transplantation of marrow from an unrelated donor to a patient with acute leukemia. N Engl J Med 303:565–567PubMedCrossRefGoogle Scholar
  20. Horowitz SD, Groshong T, Bach FH, et al (1975) Treatment of severe combined immunodeficiency with bone marrow from an unrelated mixed-leucocyte-culture-nonreactive donor. Lancet 2:431–433PubMedCrossRefGoogle Scholar
  21. Hows JM, Yin JL, Marsh J, et al (1986) Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia. Blood 68:1322–1328PubMedGoogle Scholar
  22. Koller B, Geraghty D, Shimizu Y, et al (1988) A novel HLA class I gene expressed in resting T lymphocytes. J Immunol 141:897PubMedGoogle Scholar
  23. Lohrmann H-P, Dietrich M, Goldmann SF, et al (1975) Bone marrow transplantation for aplastic anemia from a HLA and MLC-identical unrelated donor. Blut 31:347–354PubMedCrossRefGoogle Scholar
  24. Mathe G, Schwarzenberg L (1976) Treatment of bone marrow aplasia by mismatched bone marrow transplantation after conditioning with antilymphocyte globulin: Long-term results. Transplant Proc 8:595–602PubMedGoogle Scholar
  25. McGlave PB (1990) Unrelated marrow transplants for CML. International Society for Experimental Hematology, Seattle, AugustGoogle Scholar
  26. McGlave P, Scott E, Ramsay N, et al (1987) Unrelated donor bone marrow transplantation therapy for chronic myelogenous leukemia. Blood 70:877–881PubMedGoogle Scholar
  27. McGlave PB, Beatty PG, Ash R, et al (1990) Therapy for chronic myelogenous leukemia with unrelated donor bone marrow transplantation: results in 102 cases. Blood 75:1728PubMedGoogle Scholar
  28. Nesbit M, Buckley J, Lampkin B, et al (1987) Comparison of allogeneic bone marrow transplantation (BMT) with maintenance chemotherapy in previously untreated childhood acute non-lymphocytic leukemia (ANLL) (abstract). Proc Am Soc Clin Oncol 6:640aGoogle Scholar
  29. O’Reilly RJ, Dupont B, Pahwa S, et al (1977) Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor. N Engl J Med 297:1311–1318PubMedCrossRefGoogle Scholar
  30. Park BH, Biggar WD, Good RA (1975) Transplantation of incompatible bone marrow in infants with severe combined immunodeficiency disease. Birth Defects 11:380–384PubMedGoogle Scholar
  31. Speck B, Zwaan FE, van Rood J J, et al (1973) Allogeneic bone marrow transplantation in a patient with aplastic anemia using a phenotypically HLA-A identical unrelated donor. Transplantation 16:24–28PubMedCrossRefGoogle Scholar
  32. Storb R, Thomas ED, Buckner CD, et al (1984) Marrow transplantation for aplastic anemia. Semin Hematol 21:27PubMedGoogle Scholar
  33. Takahashi K, Juji T, Miyazaki H (1989) Determination of an appropriate size on unrelated donor pool to be registered for HLA-matched bone marrow transplantation. Transfusion 29:311PubMedCrossRefGoogle Scholar
  34. Thomas ED (1983) Marrow transplantation for malignant disease. (Karnofsky Memorial Lecture). J Clin Oncol 1:517PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • P. G. Beatty

There are no affiliations available

Personalised recommendations