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Typing and Grading of Gastric Dysplasia

  • Chapter
Precancerous Conditions and Lesions of the Stomach

Abstract

Most pathologists agree that gastric dysplasia, or epithelial dysplasia of the stomach, is an important precancerous change within the stomach. There is, however, much confusion about the nomenclature to be used for such changes. The term “gastric dysplasia” was proposed by a WHO Workshop on Histological Criteria of Precancerous Change of the Stomach in 1978, and it has since been used widely by pathologists [3, 5, 18–21, 27, 32, 38, 45].

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References

  1. Borchard P, Mitteistaedt A, Stux G (1979) Dysplasien im Resektionsmagen und Klassifikationsprobleme verschiedener Dysplasieformen. Verh Dtsch Ges Pathol 63:250–257

    Google Scholar 

  2. Bordi C, de Vita O (1984) Pathologia delle precancerosi gastriche e colorektali estratio. Argom Oncol 5:323–331

    Google Scholar 

  3. Cuello C, Correa P, Zarama G, Lopez J, Murrar J, Gordillo G (1979) Histopathology of gastric dysplasia. Am J Surg Pathol 3:491–500

    Article  PubMed  CAS  Google Scholar 

  4. Fukuji S, Kaiyama M, Nozotsuki K (1975) Endoscopic diagnosis of Ila-subtype borderline lesion of the stomach (in Japanese). Stomach Intest 10:1487–1493

    Google Scholar 

  5. Grundman E, Schlake W (1979) Histology of possible precancerous stages in stomach. In: Herfarth C, Schlag P (eds) Gastric cancer. Springer, Berlin Heidelberg New York, pp 72–82

    Chapter  Google Scholar 

  6. Hirota T, Itabashi M, Takizawa C, Kim B (1987) Clinicopathological characteristics of gastric adenoma and its significance as a precancerous lesion (in Japanese). Stomach Intest 22:657–664

    Google Scholar 

  7. Japanese Research Society for Gastric Cancer (1985) The general rules for the gastric cancer study, 11th edn. Kanabara, Tokyo, pp 78–100

    Google Scholar 

  8. Jarvis L, Whitehead K (1985) Morphometric analysis of gastric dysplasia. J Pathol 147:133–138

    Article  PubMed  CAS  Google Scholar 

  9. Jass JR (1980) Role of intestinal metaplasia in the histogenesis of gastric carcinoma. J Clin Pathol 33:801–810

    Article  PubMed  CAS  Google Scholar 

  10. Jass JR (1988) Classification of gastric dysplasia. Histopathology 7:181–193

    Article  Google Scholar 

  11. Kikuchi M, Nakamura K, Akabane H, Shibuya S (1984) Objectification of histologic diagnosis on protruded lesion of atypical epithelium and differentiated carcinoma of stomach: numerical value of structural atypism by morphometric analysis (Engl summary). Stomach Intest 19:1117–1125

    Google Scholar 

  12. Li JY, Ho L, Xie YQ, He JS, Jin BQ (1989) Cystic dilatation of the dysplastic gland in gastric mucosa and its relation with gastric cancer (in Chinese). Chinese J Dig 9:230–231

    Google Scholar 

  13. Liu SQ, Zhang YC (1987) A newly recognized precancerous lesion of the stomach (Engl abstr). J China Med Univ 16:321–325

    Google Scholar 

  14. Liu SQ, Zhang YC (1988) The histopathological classification of globoid dysplasia and its relationship with signet ring cell carcinoma (Engl abstr). J China Med Univ 17:1–6

    Google Scholar 

  15. Liu SQ, Zhang YC (1988) The cellular histochemical and immunohistochemical studies on the globoid dysplasia of the human gastric epithelium (Engl abstr). J China Med Univ 17:92–102

    Google Scholar 

  16. Liu SQ, Zhang YC (1989) Histopathologic features of globoid dysplasia of the human gastric epithelium (Engl abstr). Chung Hua Chung Liu Tsa Chin 11:37–40

    CAS  Google Scholar 

  17. Liu SQ, Zhang YC (1989) Characteristics of mucins and CEA in globoid dysplastic cells of human stomach and its relationship with signet ring cell carcinoma (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 11:176–179

    CAS  Google Scholar 

  18. Ming SC (1984) Precursors of gastric cancer. Praeger, New York

    Google Scholar 

  19. Ming SC, Bajtai A, Correa P, Elster K, Jarvi OH, Munoz N, Nagayo T, Stemmerman GN (1984) Gastric dysplasia. Significance and pathologic criteria. Cancer 54: 1794–1800

    CAS  Google Scholar 

  20. Morson BC, Sobin LH, Grundmann E, Johansen A, Nagayo T, Serck-Hanssen A (1980) Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol 33:711–721

    Article  PubMed  CAS  Google Scholar 

  21. Nagayo T (1982) Gastric mucosal dysplasia and precancerous lesion (in Japanese). In: Kusama S, Wada T, Miye M (eds) Surgery, vol 28. Kanabara, Tokyo

    Google Scholar 

  22. Nagayo T (1986) Histogenesis and precursors of human gastric cancer. Springer, Berlin Heidelberg New York, pp 126–140

    Chapter  Google Scholar 

  23. Nagayo T, Suzuki R, Sato T, Suchi T (1987) Retrospective histological studies on biopsied gastric lesions of patients in whom cancer was diagnosed at follow-up examination. Gann 78:997–1005

    Google Scholar 

  24. Nakamura K (1982) Structure of the gastric cancer, 1st edn (in Japanese). Igaku Shoin, Tokyo

    Google Scholar 

  25. Nakamura K, Sugano H, Takagi K, Fuchigami A (1966) Histopathological study or early carcinoma of the stomach. Criteria for diagnosis of atypical epithelium. Gann 57:613–620

    CAS  Google Scholar 

  26. Nakamura K, Sakaguchi H, Enjoji M (1988) Depressed adenoma of the stomach. Cancer 62:2197–2202

    Article  PubMed  CAS  Google Scholar 

  27. Oehler W (1979) Biological significance of dysplasia of the epithelium and of atrophic gastritis. In: Herfarth CH, Schlag P (eds) Gastric cancer. Springer, Berlin Heidelberg New York, pp 91–104

    Chapter  Google Scholar 

  28. Sano L (1975) Benign and malignant borderline lesions of the stomach (in Japanese). Stomach Intest 10:1433–1435

    Google Scholar 

  29. Sugano H (1972) The pathological morphology of the borderline lesion in digestive tract: atypical epithelium of the stomach (in Japanese). Gan No Rinsho 18:834–842

    Google Scholar 

  30. Wang RN, Zhao ML, Su, BH, Ziao SD, Jiang SJ (1988) A model assessment of gastric precancerous lesions by morphometric analysis. Chin Med J [Engl] 101: 403–409

    CAS  Google Scholar 

  31. Watanabe H (1978) Argentaffin cells in adenoma of the stomach. Cancer 30: 1267–1274

    Article  Google Scholar 

  32. World Health Organization (1972) Report of a WHO meeting on the histological definition of precancerous lesions. WHO, Geneva

    Google Scholar 

  33. World Health Organization (1987) Establishment of international registration system for gastric dysplasia. WHO CC News Lett 18

    Google Scholar 

  34. Wu YQ, Yen RF, Zhang YC (1988) Computer diagnosis of gastric dysplasia and program design (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 10:24–26

    Google Scholar 

  35. Xiao SD, Jiang SJ, Wang RN, Hu YB, Liu WZ, Tang XM (1986) N-ethyl-N’-nitro-N-nitrosoguanidine induced gastric carcinoma in wolf-dogs useful model for tracing gastric malignancy transformation. Chin Med J [Engl] 99:903–907

    CAS  Google Scholar 

  36. Yen RF, Zhang YC, Wu YQ (1987) Morphological measurement for diagnosis of gastric dysplasia (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 9:401–404

    Google Scholar 

  37. Yen RF, Zhang YC, Wu YQ (1989) Morphometric indexes and computerized diagnosis of gastric dysplasia. Proc CAMS and PUMC 4:43–47

    Google Scholar 

  38. Zhang YC (1983) Epithelial dysplasia of the stomach and its relationship with gastric cancer. 6th Asia Pacific Cancer Conference, Sendi

    Google Scholar 

  39. Zhang YC (1984) Epithelial dysplasia of the stomach and its relationship with gastric cancer. In: Ming SC (ed) Precursors of gastric cancer. Praeger, New York, pp 41–52

    Google Scholar 

  40. Zhang YC (1988) Gastric dysplasia. In: Zhang YC (ed) Pathology of the stomach and gastric mucosal biopsy (in Chinese). Liaoning, Shenyang pp 56–74

    Google Scholar 

  41. Zhang YC (1989) Pathology of the start point of malignant change from gastric dysplasia (Engl abstr). J Chin Med Univ 18:337–341

    Google Scholar 

  42. Zhang YC (1990) Malignant change detected in regenerative type of gastric dysplasia. 79th Meeting of the Japanese Pathologic Association, Fukuoka

    Google Scholar 

  43. Zhang YC, Bai XZ, Zhang WF (1979) Histopathologic study of atypical epithelial proliferation of the gastric mucosa and its follow-up study (Engl abstr). Zhonghua Zhongliu Zazhi (Chin J Oncol) 1:23–28

    CAS  Google Scholar 

  44. Zhang YC, Sun ZX, Lin HZ, Zhang WF, Bai XW, Aoki K, Kawai K, Sasaki R, Tsychihashi Y, Ito Y, Watanabe N (1987) Spectrum of gastric diseases in North China. In: Wada T, Aoki K, Yachi A (eds) Current status of cancer research in Asia, the Middle East and other countries. UICC-JCA joint conference. University of Nagoya Press, Nagoya, pp 41–49

    Google Scholar 

  45. Zhang YC, Zhang PF, Wang MX, Liu SQ (1988) Histopathologic types of gastric dysplasia. Chin J Cancer Res 1:47–52

    Article  Google Scholar 

  46. Zhao ML, Wang RN, Deng YL, Yao JS, Xiao SD, Jiang SJ, Ju HG, Chen DH, Li ZP (1985) A morphometric analysis of gastric precancerous lesions. Quantitative diagnosis of structural atypism in gastric mucosal biopsies. Chin J Dig 5:205–206

    Google Scholar 

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Authors and Affiliations

  1. Cancer Institute of China Medical University, 5-3 Nanjing Street, Heping District, Shenyang, P.R. China

    Y.-C. Zhang

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  1. Y.-C. Zhang
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Editors and Affiliations

  1. Cancer Institute of China Medical University, 5-3 Najing Street, Heping District, Shenyang, 110001, People’s Republic of China

    Ying-Chang Zhang (Deputy Director) (Deputy Director)

  2. Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602, Japan

    Keiichi Kawai

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© 1993 Springer-Verlag Berlin Heidelberg

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Zhang, YC. (1993). Typing and Grading of Gastric Dysplasia. In: Zhang, YC., Kawai, K. (eds) Precancerous Conditions and Lesions of the Stomach. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77495-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-77495-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77497-3

  • Online ISBN: 978-3-642-77495-9

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