Stationary Phases for Packed Column Supercritical Fluid Chromatography

  • Colin F. Poole
  • John W. Oudsema
  • Thomas A. Dean
  • Salwa K. Poole


Virtually all contemporary research using packed columns in SFC is performed with column packings and column dimensions optimized for high pressure liquid chromatography (HPLC) [1]. This catalyzed the early development of practical applications of packed column SFC and provided a variety of stationary phase chemistries to optimize individual separations with the limited selection of available supercritical fluids with favorable critical constants. The lack of a reliable theoretical framework for kinetic optimization of column parameters has also served to deflect attention from the question of whether columns designed for the separation of low-molecular-weight solutes with incompressible liquids are necessarily ideal for the typical separations most suited to SFC [2]. It is still too early to answer this question definitively but at least some positive statements can be made concerning column dimensions, packings, and operating conditions that are most useful for SFC.


High Pressure Liquid Chromatography Supercritical Fluid Silanol Group Free Silanol Group Supercritical Fluid Carbon Dioxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Colin F. Poole
  • John W. Oudsema
  • Thomas A. Dean
  • Salwa K. Poole

There are no affiliations available

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