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Gradients in SFC

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Analysis with Supercritical Fluids: Extraction and Chromatography

Abstract

One of the features of supercritical fluid chromatography (SFC) which differentiates this type of chromatography from the neighboring chromatographic methods, gas chromatography (GC) and liquid chromatography (LC), is the larger number of gradients which may be useful in SFC. Gradients of temperature, pressure, density, linear velocity, and of the composition of the mobile phase, all greatly influence the chromatographic separation. So far, most often pressure and density have been programmed to form gradients, followed by temperature and composition gradients. Velocity gradients have been seldom used as single gradients, but they have been employed routinely in capillary SFC as a means of creating a pressure or density gradient. This combination of two gradients is, however, due to hardware limitations because the commercially available hardware for capillary SFC does not yet allow the programming of pressure without programming velocity at the same time.

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Authors
  1. Ernst Klesper
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  2. Franz P. Schmitz
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Editor information

Editors and Affiliations

  1. Fachbereich 8, Analytische Chemie I, Universität-GH Siegen, Adolf-Reichwein-Straße, W-5900, Siegen, Germany

    Bernd Wenclawiak

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© 1992 Springer-Verlag Berlin Heidelberg

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Klesper, E., Schmitz, F.P. (1992). Gradients in SFC. In: Wenclawiak, B. (eds) Analysis with Supercritical Fluids: Extraction and Chromatography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77474-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-77474-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77476-8

  • Online ISBN: 978-3-642-77474-4

  • eBook Packages: Springer Book Archive

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