Skip to main content
SpringerLink
Log in

Oxygen Deficiency During Fetal Development and Delivery — Speculations About Clinical Conditions

  • Conference paper
OXYGEN: Basis of the Regulation of Vital Functions in the Fetus

Abstract

There is no doubt that fetal development is dependent on a sufficient oxygen supply. This includes ovulation, the passage through the fallopian tube, implantation, and placentation itself. The establishment of the vascular system facilitates the oxygen transfer from the mother to the fetus and ultimately the oxygen transport to the fetal tissue (Bartels and Baumann 1972; Longo et al. 1972; Moll 1972; Wulf et al. 1972).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Acheson GH, Dawes GS, Mott JC (1957) Oxygen consumption and the arterial oxygen saturation in foetal and newborn lambs. J Physiol (Lond) 135: 623

    CAS  Google Scholar 

  • Ballew C, Haas JD (1986) Hematologic evidence of fetal hypoxia among newborn infants at high altitude in Bolivia. Am J Obstet Gynecol 155: 166–169

    PubMed  CAS  Google Scholar 

  • Bartels H, Baumann F (1972) Preplacental gas exchange. In: Longo LD, Bartels H (eds) Respiratory gas exchange and blood flow in the placenta. D. H. E. W. Publication, No NIH 73/361, pp 1–11

    Google Scholar 

  • Block BSB, Llanos AJ, Creasy RK (1984) Responses of the growth-retarded fetus to acute hypoxemia. Am J Obstet Gynecol 148: 878–885

    PubMed  CAS  Google Scholar 

  • Carter AM (1989) Factors affecting gas transfer across the placenta and the oxygen supply to the fetus. J Dev Physiol 12: 305–322

    PubMed  CAS  Google Scholar 

  • Clapp JF (1978) The relationship between blood flow and oxygen uptake in the uterine and umbilical circulations. Am J Obstet Gynecol 132: 410–413

    PubMed  Google Scholar 

  • Clapp JF, Szeto HH, Larrow R, Hewitt J, Mann LI (1980) Umbilical blood flow response to embolization of the uterine circulation. Am J Obstet Gynecol 138: 60–67

    PubMed  Google Scholar 

  • Dawes, GS (1968) The placenta and fetal growth. In: Dawes GS (ed) Fetal and neonatal physiology. Yearbook Medical Publishers, Chicago, pp 42–59

    Google Scholar 

  • Edelstone DI, Cinae ME, Fumia FD (1985) Relationship of fetal oxygen consumption and acid-base balance to fetal hematocrit. Am J Obstet Gynecol 151: 844–851

    PubMed  CAS  Google Scholar 

  • Emmrich P (1981) Diabetes mellitus der Mutter. In: Becker V, Schiebler TH, Kubli F (eds) Die Plazenta des Menschen. Thieme, Stuttgart, pp 359–368

    Google Scholar 

  • Greiss FC (1965) Effect of labor on uterine blood flow. Am J Obstet Gynecol 93: 917

    PubMed  Google Scholar 

  • Gruenwald P (1969) Still birth and early neonatal death. In: Butler NR, Alberman ED (eds) Perinatal problems. Livingstone, Edinburgh, p 163

    Google Scholar 

  • Harbert GM (1982) Effects of uterine contractions. In: Mohawad AH, Lindheimer MD (eds) Uterine and placental blood flow, pp 193–200

    Google Scholar 

  • Hohmann M, Künzel W (1990) Hypotonie und Schwangerschaft. Gynakologe 23: 33–40

    PubMed  CAS  Google Scholar 

  • Hohmann M, Künzel W, Kirschbaum M (1986) Wehenbelastungstest mit Oxytocin-NasenSpray zur Diagnose der fetalen Hypoxämie. Z Geburtshilfe Perinatol 190: 210–214

    PubMed  CAS  Google Scholar 

  • Hughes AB, Jenkins DA, Newcombe RG, Pearson JF (1987) Symphysis-fundus height, maternal height, labor pattern, and mode of delivery. Am J Obstet Gynecol 156: 644–648

    PubMed  CAS  Google Scholar 

  • Ibsen HL (1928) Prenatal growth in guinea pigs with special reference to environmental factors affecting weight at birth. J Exp 200 1 51: 51–91

    Google Scholar 

  • Itskovitz J, LaGamma EF, Rudolph AM (1983) The effect of reducing umbilical blood flow on fetal oxygenation. Am J Obstet Gynecol 145: 813–818

    PubMed  CAS  Google Scholar 

  • Itskovitz J, LaGamma EF, Rudolph EM (1987) Effects of cord compression on fetal blood flow distribution and O2 delivery. Am J Physiol 252: H110–H109

    Google Scholar 

  • Jensen A, Künzel W, Hohmann M (1985) Fetal heart rate and fetal deterioration: clinical and experimental observations. In: Künzel W (ed) Fetal heart rate monitoring. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Jensen A, Hohmann M, Künzel W (1987) Dynamic changes in organ blood flow and oxygen consumption during acute asphyxia in fetal sheep. J Dev Physiol 9: 543–559

    PubMed  CAS  Google Scholar 

  • Junge HD, Künzel W, Klöck FK (1977) Acute reduction of uterine blood flow and fetal heart rate changes in pregnant sheep near term. J Perinat Med 5: 39

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann P (1981) Entwicklung der Plazenta. In: Becker V, Schiebler TH, Kubli F (eds) Die Plazenta des Menschen. Thieme, Stuttgart, pp 13–50

    Google Scholar 

  • Künzel W (1973) Die Durchblutung am Ende der Schwangerschaft und während der Geburt. In: Dudenhausen JW, Saling E (eds) Perinatale Medizin, vol IV. Thieme, Stuttgart, p 127

    Google Scholar 

  • Künzel W (1986) Fetal heart rate monitoring: clinical practice and pathophysiology. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Künzel W (1989) Das aktuelle kindliche Risiko. In: Hillemanns HG, Schillinger H (eds) Das Restrisiko gegenwärtiger Geburtshilfe. Springer, Berlin Heidelberg New York Tokyo, pp 111–115

    Google Scholar 

  • Künzel W, Hohmann M (1989) Grundlagen der kardiotokographischen Überwachung des Feten während der Schwangerschaft. Gynakologe 22: 156–161

    PubMed  Google Scholar 

  • Künzel W, Moll W (1972) Uterine O2 consumption and blood flow of the pregnant uterus. Z Geburtshilfe Perinatol 178: 108

    Google Scholar 

  • Künzel W, Junge HD, Klöck FK, Moll W (1972) The effect of low molecular weight dextran on uterine blood flow and the gas partial pressure on the fetal blood. Z Geburtshilfe Perinatol 176: 290

    PubMed  Google Scholar 

  • Künzel W, Klöck FK, Junge HD, Moll W (1974) Uterine blood flow, oxygen uptake and vascular resistance of pregnant sheep near term. J Perinat Med 2: 101

    Article  PubMed  Google Scholar 

  • Künzel W, Mann LE, Bhakthavathsalan A, Ayromlooi J (1977) The effect of umbilical vein occlusion on fetal oxygenation — cardiovascular parameters and fetal electroencephalogram. Am J Obstet Gynecol 128: 201–208

    PubMed  Google Scholar 

  • Künzel W, Kastendieck E., Hohmann M (1983) Heart rate and blood pressure response and metabolic changes in the sheep fetus following reduction of uterine blood flow. Gynecol Obstet Invest 15: 300

    Article  PubMed  Google Scholar 

  • Lang U, Künzel W (1989) Diabetes mellitus in pregnancy. Management and outcome of diabetic pregnancies in the state of Hesse, FRG; a five-year-survey. Eur J Obstet Gynecol Reprod Biol 33: 115–129

    Article  PubMed  CAS  Google Scholar 

  • Longo LD, Hill EP, Power GG (1972) Factors afacting placental oxygen transfer. In: Longo LD, Bartels H (eds) Resperatory gas exchange and blood flow in the placenta. D. H. E.W. Publication, No NIH 73/361, pp 345–393

    Google Scholar 

  • Moll W (1972) Gas exchange in concurrent, countercurrent and crosscurrent flow systems. The concept of the fetoplacental unit. In: Longo LD, Bartels H (eds) Respiratory gas exchange and blood flow in the placenta. U.S. Department of Health, Education and Welfare, Bethesda

    Google Scholar 

  • Moll W, Künzel W (1974) Der uteroplacentare Kreislauf. Z Geburtshilfe Perinatol 178: 1

    PubMed  CAS  Google Scholar 

  • Owens JA, Falconer J, Robinson J (1987) Effect of restriction of placental growth on fetal and utero-placental metabolism. J Dev Physiol 9: 225–238

    PubMed  CAS  Google Scholar 

  • Parer JT, De Lammoy CW, Hoversland AS, Metcalfe J (1968) Effect of decreased uterine blood flow on uterine oxygen consumption in pregnant macagues. Am J Obstet Gynecol 100: 813

    PubMed  CAS  Google Scholar 

  • Paulone ME, Edelstone DI, Schedd A (1987) Effects of maternal anemia on uteroplacental and fetal oxidative metabolism in sheep. Am J Obstet Gynecol 156: 230–236

    PubMed  CAS  Google Scholar 

  • Soothill PW, Nicolaides KH, Campbell S (1987) Prenatal asphyxia, hyperlacticaemia, hypoglycaemia, and erythroblastosis in growth retarded fetuses. Br Med J 294: 1051–1053

    Article  CAS  Google Scholar 

  • Soothill PW, Nicolaides KH, Rodeck CH, Campbell S (1986b) Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy. Fetal Ther 1: 168–175

    Article  PubMed  CAS  Google Scholar 

  • Soothill PW, Nicolaides KH, Rodeck CH, Gamsu H (1986a) Blood gases and acid-base status of the human second-trimester fetus. Obstet Gynecol 68: 173–176

    PubMed  CAS  Google Scholar 

  • Steiner M (1989) Perinatalstudien in Deutschland. In: Hillemanns HG, Schillinger H (eds) Das Restrisiko gegenwärtiger Geburtshilfe. Springer, Berlin Heidelberg New York Tokyo, pp 101–110

    Google Scholar 

  • Wigglesworth JS (1964) Experimental growth retardation in the foetal rat. J Pathol Bacteriol 88: 1–13

    Article  PubMed  CAS  Google Scholar 

  • Wulf KH, Künzel W, Lehmann V (1972) Clinical aspects of placental gas exchange. In: Longo LD, Bartels H (eds) Resperatory gas exchange and blood flow in the placenta. D. H. E. W. Publication, No NIH 73/361, pp 505–525

    Google Scholar 

Download references

Authors
  1. W. Künzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Hohmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Braems
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. der Justus-Liebig-Universität, Klinikstraße 32, 6300, Gießen, Bundesrepublik Deutschland

    Wolfgang Künzel (Gf. Direktor der Frauenklinik und Hebammenschule) (Gf. Direktor der Frauenklinik und Hebammenschule)

  2. Frauenklinik der Justus-Liebig-Universität, Klinikstraße 32, 6300, Gießen, Bundesrepublik Deutschland

    Michael Kirschbaum

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Künzel, W., Hohmann, M., Braems, G. (1992). Oxygen Deficiency During Fetal Development and Delivery — Speculations About Clinical Conditions. In: Künzel, W., Kirschbaum, M. (eds) OXYGEN: Basis of the Regulation of Vital Functions in the Fetus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77469-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77469-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77471-3

  • Online ISBN: 978-3-642-77469-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation