Peptidase Inactivation of Enkephalins: Design of Inhibitors and Biochemical, Pharmacological, and Clinical Applications

Roques, B. P.; Beaumont, A.; Dauge, V.; Fournié-Zaluski, M.-C.

doi:10.1007/978-3-642-77460-7_23

B. P. Roques,
A. Beaumont,
V. Dauge &
…
M.-C. Fournié-Zaluski

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 1))

409 Accesses
6 Citations

Abstract

Because of their critical role in various adaptational processes, extensive pharmacological studies have been devoted to the neuropeptides, a family of chemical messengers acting in the central nervous system as neurotransmitters and/or neuromodulators. This is particularly true for the opioid peptides, which are involved in the control of pain and modulation of mood through their interaction with different classes of binding sites.

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B. P. Roques
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A. Beaumont
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V. Dauge
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M.-C. Fournié-Zaluski
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Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany
Albert Herz
Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Picher, 48109, Ann Arbor, MI, USA
Huda Akil
Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA
Eric J. Simon

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Roques, B.P., Beaumont, A., Dauge, V., Fournié-Zaluski, MC. (1993). Peptidase Inactivation of Enkephalins: Design of Inhibitors and Biochemical, Pharmacological, and Clinical Applications. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids. Handbook of Experimental Pharmacology, vol 104 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77460-7_23

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