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Selective Nonpeptide Opioid Antagonists

  • Chapter
Opioids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 104 / 1))

Abstract

Opioid antagonists have been indispensable as tools in opioid research (Zimmerman and Leander 1990). In fact, the chief criterion for the classification of an agonist effect as opioid receptor-mediated is the ability of naloxone (Sawynok et al. 1979) or naltrexone (Gold et al. 1982) to reversibly antagonize this effect in a competitive fashion. The usefulness of these ligands for this purpose stems from the fact that they are universal opioid antagonists; that is, they are capable of antagonizing the agonist effects mediated by multiple opioid receptor types.

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Authors
  1. P. S. Portoghese
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Editors and Affiliations

  1. Abteilung Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18, W-8033, Martinsried, Germany

    Albert Herz

  2. Mental Health Research Institute, School of Medicine, University of Michigan, 205 Zina Picher, 48109, Ann Arbor, MI, USA

    Huda Akil

  3. Medical Center, School of Medicine, New York University, 550 First Avenue, 10016, New York, NY, USA

    Eric J. Simon

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© 1993 Springer-Verlag Berlin Heidelberg

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Portoghese, P.S. (1993). Selective Nonpeptide Opioid Antagonists. In: Herz, A., Akil, H., Simon, E.J. (eds) Opioids. Handbook of Experimental Pharmacology, vol 104 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77460-7_12

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  • DOI: https://doi.org/10.1007/978-3-642-77460-7_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77462-1

  • Online ISBN: 978-3-642-77460-7

  • eBook Packages: Springer Book Archive

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