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Transplant International Official Journal of the European Society for Organ Transplantation pp 75–78Cite as

Effect of ATG prophylaxis in sensitized and non-sensitized kidney graft recipients

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Abstract

In our effort to find an optimum immunosuppressive protocol for kidney transplantation we introduced two forms of ATG prophylaxis: 1. high-dose single-bolus prophylaxis (9 mg/kg) in non-sensitized patients (PRA <5%); and 2. low-dose 8-day prophylaxis (1.5–3.0 mg/kg) in sensitized patients (PRA > 5%). A total of 204 kidney graft recipients were included in this study and treated with a triple-drug therapy (TDT). In comparison with TDT-treated controls, in sensitized patients the 8-day ATG prophylaxis resulted in a reduced rate of rejection episodes (25.5% vs 47%), an improved 1-year graft survival (82% vs 71%) and patient survival (94% vs 90%). In non-sensitized patients the high-dose single-bolus ATG prophylaxis induced a T-cell lymphopenia lasting 4 to 5 days and, in comparison with the corresponding controls, resulted in a shortened hospital stay (31.2 days vs 36.7 days), a reduced rate of rejection episodes (25.5% vs 53%), an improved 1-year graft survival (92% vs 86%) and patient survival (100% vs 94%).

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Author information

Authors and Affiliations

  1. Kidney Transplant Centre, Clinic of Urology, Friedrichshain Hospital, Berlin, Germany

    G. May, P. Müller, W. Seeger & F. Seibt

  2. Department of Immunology, Clinic of Urology, Friedrichshain Hospital, Berlin, Germany

    J. Kaden, C. Schönemann, J. Groth & M. Henkert

  3. Humboldt University, Faculty of Medicine, Clinic of Urology, Berlin, Germany

    J. Lippert

Authors
  1. G. May
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  2. P. Müller
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  3. W. Seeger
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  4. F. Seibt
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  5. J. Kaden
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  6. C. Schönemann
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  7. J. Groth
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  8. M. Henkert
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  9. J. Lippert
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Editor information

Editors and Affiliations

  1. Department of Surgery, University Hospital, P.O.Box 5800, 6202 AZ, Maastricht, The Netherlands

    Gauke Kootstra

  2. Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, W-6900, Heidelberg, Germany

    Gerhard Opelz

  3. Department of Surgery, University of Limburg, (B. M. C.) Beeldsnijderdreef 101, NL-6216 EA, Maastricht, The Netherlands

    W. A. Buurman

  4. Department of Nephrology, University Hospital Maastricht, P. Debyelaan 25, NL-6202 AZ, Maastricht, The Netherlands

    J. P. van Hooff

  5. The Liver Unit, Queen Elizabeth Hospital, B152TH, Edgbaston, Birmingham, UK

    P. MacMaster

  6. Papworth Hospital, CB3 8RE, Papworth Everard, Cambridgeshire, UK

    J. Wallwork

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© 1992 Springer-Verlag Berlin Heidelberg

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May, G. et al. (1992). Effect of ATG prophylaxis in sensitized and non-sensitized kidney graft recipients. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_25

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  • DOI: https://doi.org/10.1007/978-3-642-77423-2_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55342-7

  • Online ISBN: 978-3-642-77423-2

  • eBook Packages: Springer Book Archive

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