Non specific increased expression of class I major histocompatibility complex (MHC) antigens on rat liver grafts

  • J. Gugenheim
  • L. Amorosa
  • B. Fabiani
  • F. Crafa
  • M. Reynes
  • I. Astarcioglu
  • M. Gigou
  • H. Bismuth
Conference paper

Abstract

Major histocompatibility complex (MHC) antigens play a major role in the rejection reaction and their increased expression may increase the host response to the foreign graft [1]. Several clinical [2–5] and experimental studies [6, 7] have demonstrated increased expression of MHC antigens on the different cell components of liver allografts during rejection. However modified expression of MHC antigens may also occur in certain liver diseases [8–10], after cholestasis [11] or on a regenerating liver [11]. In this experimental study in inbred rats, we compared the expression of MHC antigens on liver cells during rejection and non-immunological situations (cholestasis, cytolysis, regeneration).

Key words

MHC antigens BN rats Rejection 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. Gugenheim
    • 1
  • L. Amorosa
    • 1
  • B. Fabiani
    • 2
  • F. Crafa
    • 1
  • M. Reynes
    • 2
  • I. Astarcioglu
    • 3
  • M. Gigou
    • 3
  • H. Bismuth
    • 3
  1. 1.Laboratoire de Recherches Chirurgicales et Service de Chirurgie DigestiveHôpital Saint-RochNice CedexFrance
  2. 2.Laboratoire d’anatomie PathologiqueHôpital Paul BrousseVillejuifFrance
  3. 3.Unité de Chirurgie HépatobiliaireHôpital Paul BrousseVillejuifFrance

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