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Transplant International Official Journal of the European Society for Organ Transplantation pp 629–630Cite as

Non specific increased expression of class I major histocompatibility complex (MHC) antigens on rat liver grafts

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Abstract

Major histocompatibility complex (MHC) antigens play a major role in the rejection reaction and their increased expression may increase the host response to the foreign graft [1]. Several clinical [2–5] and experimental studies [6, 7] have demonstrated increased expression of MHC antigens on the different cell components of liver allografts during rejection. However modified expression of MHC antigens may also occur in certain liver diseases [8–10], after cholestasis [11] or on a regenerating liver [11]. In this experimental study in inbred rats, we compared the expression of MHC antigens on liver cells during rejection and non-immunological situations (cholestasis, cytolysis, regeneration).

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Author information

Authors and Affiliations

  1. Laboratoire de Recherches Chirurgicales et Service de Chirurgie Digestive, Hôpital Saint-Roch, B. P. 31906006, Nice Cedex, France

    J. Gugenheim, L. Amorosa & F. Crafa

  2. Laboratoire d’anatomie Pathologique, Hôpital Paul Brousse, 94800, Villejuif, France

    B. Fabiani & M. Reynes

  3. Unité de Chirurgie Hépatobiliaire, Hôpital Paul Brousse, 94800, Villejuif, France

    I. Astarcioglu, M. Gigou & H. Bismuth

Authors
  1. J. Gugenheim
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  2. L. Amorosa
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  3. B. Fabiani
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  4. F. Crafa
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  5. M. Reynes
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  6. I. Astarcioglu
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  7. M. Gigou
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  8. H. Bismuth
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Editor information

Editors and Affiliations

  1. Department of Surgery, University Hospital, P.O.Box 5800, 6202 AZ, Maastricht, The Netherlands

    Gauke Kootstra

  2. Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, W-6900, Heidelberg, Germany

    Gerhard Opelz

  3. Department of Surgery, University of Limburg, (B. M. C.) Beeldsnijderdreef 101, NL-6216 EA, Maastricht, The Netherlands

    W. A. Buurman

  4. Department of Nephrology, University Hospital Maastricht, P. Debyelaan 25, NL-6202 AZ, Maastricht, The Netherlands

    J. P. van Hooff

  5. The Liver Unit, Queen Elizabeth Hospital, B152TH, Edgbaston, Birmingham, UK

    P. MacMaster

  6. Papworth Hospital, CB3 8RE, Papworth Everard, Cambridgeshire, UK

    J. Wallwork

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© 1992 Springer-Verlag Berlin Heidelberg

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Gugenheim, J. et al. (1992). Non specific increased expression of class I major histocompatibility complex (MHC) antigens on rat liver grafts. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_185

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  • DOI: https://doi.org/10.1007/978-3-642-77423-2_185

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55342-7

  • Online ISBN: 978-3-642-77423-2

  • eBook Packages: Springer Book Archive

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