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The influence of DR match of blood donor and recipient on the formation of T- and B-cell antibodies and on renal allograft outcome

  • J. P. van Hooff
  • P. M. van den Berg-Loonen
Conference paper

Abstract

It has been shown that patients transfused with one unit of blood mismatched for both HLA DR antigens have an increased rate of formation of cytotoxic leukocyte antibodies compared to patients who received blood which differs in only one DR antigen. In the same study it was found that DR sharing of the blood transfusion donor and patient improved results of kidney and heart transplantation. However, the data were mostly collected in a retrospective manner and came from various centers. Furthermore, no information was available on whether these antibodies were directed to B- or T-cells. Therefore, the influence of DR match of recipient and blood donor on the formation of T- and B-cell antibodies as well as on clinical course after kidney transplantation was studied prospectively in patients transplanted in one centre.

Key words

DR match Blood donor and recipient T- and B-cell antibodies Kidney transplantation 

References

  1. 1.
    Lagaay EL, Hennemann IPH, Ruigrok M, et al (1989) Effect of one-HLA-DR-antigen-matched and completely HLA-DR-mis-matched blood transfusions on survival of heart and kidney allografts. N Engl J Med 321:701CrossRefGoogle Scholar
  2. 2.
    Opelz G, Graver B, Mickey MR, Terasaki PI (1981) Lymphocy-toxic antibody responses to transfusions in potential kidney transplant recipients. Transplantation 32:177–183PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. P. van Hooff
    • 1
  • P. M. van den Berg-Loonen
    • 1
  1. 1.Department of Internal MedicineAZ, MaastrichtThe Netherlands

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