Abstract
Severe trauma and systemic sepsis are important precursors of life-threatening lung injury. Smaller injuries such as those occurring with brief periods of ischemia and reperfusion during abdominal aortic surgery result in transient lung dysfunction. The hallmark of injury is increased microvascular permeability, i.e., noncardiogenic pulmonary edema and hypoxia. This review will examine several models of remote organ injury that result in acute respiratory failure and will highlight the inflammatory mediators that appear to be responsible.
Supported in part by the National Institutes of Health, grants GM 24891–11, GM 35141–03, HL 16714–13; the U. S. Navy Office of Naval Research, contract no. N00014–88-C-0118; the Brigham Surgical Group, Inc.; and the Trauma Research Foundation.
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© 1993 Springer-Verlag, Berlin Heidelberg
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Lindsay, T., Hill, J., Valeri, C.R., Shepro, D., Hechtman, H.B. (1993). Mediators of Remote Lung Injury. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_25
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DOI: https://doi.org/10.1007/978-3-642-77405-8_25
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