Abstract
Severe trauma and systemic sepsis are important precursors of life-threatening lung injury. Smaller injuries such as those occurring with brief periods of ischemia and reperfusion during abdominal aortic surgery result in transient lung dysfunction. The hallmark of injury is increased microvascular permeability, i.e., noncardiogenic pulmonary edema and hypoxia. This review will examine several models of remote organ injury that result in acute respiratory failure and will highlight the inflammatory mediators that appear to be responsible.
Supported in part by the National Institutes of Health, grants GM 24891–11, GM 35141–03, HL 16714–13; the U. S. Navy Office of Naval Research, contract no. N00014–88-C-0118; the Brigham Surgical Group, Inc.; and the Trauma Research Foundation.
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References
Klausner JM, Paterson IS, Mannick J, Valeri CR, Shepro D, Hechtman HB (1989) Reperfusion pulmonary edema. JAMA 261:1030–1035
Welbourn R, Goldman G, Lindsay T, Hill J, Shepro D, Hechtman HB (1991) Lung injury following hindlimb ischemia is mediated by neutrophil CD18 adherence receptors. FASEB J 5:6502 (Abstract)
Wiles M, Welbourn R, Goldman G, Hechtman HB, Shepro D (1991) Thromboxane-induced neutrophil adhesion to aortic and pulmonary microvesicular endothelium is regulated by CD18. Inflammation 15:181–199
Granger DN (1988) Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255:H1269–1275
Tracey KJ, Beutler B, Lowry SF, Merryweather J, Wolpe S, Milsark IW, Hariri RJ, Fahey III, TJ, Zentella A, Albert JD, Shires GT, Cerami A (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234:470–474
Bevilacqua MP, Prober JS, Mendrick DL, Cotran RS, Gimbrone MA (1987) Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci USA 84:9238–9242
Colletti LM, Remick DG, Burtch GD, Kunkel SL, Stieter RM, Campbell DA (1990) Role of tumor necrosis factor in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in rat. J Clin Invest 85:1936–1943
Caty MG, Guice KS, Oldham KT, Remick DG, Kunkel SI (1990). Evidence for a tumor necrosis factor induced pulmonary microvascular injury after intestine ischemia reperfusion injury. Ann Surg 212:694–700
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© 1993 Springer-Verlag, Berlin Heidelberg
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Lindsay, T., Hill, J., Valeri, C.R., Shepro, D., Hechtman, H.B. (1993). Mediators of Remote Lung Injury. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_25
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DOI: https://doi.org/10.1007/978-3-642-77405-8_25
Publisher Name: Springer, Berlin, Heidelberg
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